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6FMB
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CRYSTAL STRUCTURE OF THE BEC1054 RNASE-LIKE EFFECTOR FROM THE FUNGAL PATHOGEN BLUMERIA GRAMINIS
Descriptor:CSEP0064 putative effector protein
Authors:Jones, R., Garnett, J., Spanu, P.D., Cota, E.
Deposit date:2018-01-30
Release date:2018-06-20
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal structure of the BEC1054 RNase-like effector from the fungal pathogen Blumeria graminis
Biorxiv, 2018
1FIW
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THREE-DIMENSIONAL STRUCTURE OF BETA-ACROSIN FROM RAM SPERMATOZOA
Descriptor:BETA-ACROSIN HEAVY CHAIN, BETA-ACROSIN LIGHT CHAIN, BETA-L-FUCOSE, ...
Authors:Tranter, R., Read, J.A., Jones, R., Brady, R.L.
Deposit date:2000-08-07
Release date:2000-11-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Effector sites in the three-dimensional structure of mammalian sperm beta-acrosin.
Structure Fold.Des., 8, 2000
1FIZ
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THREE DIMENSIONAL STRUCTURE OF BETA-ACROSIN FROM BOAR SPERMATOZOA
Descriptor:BETA-ACROSIN HEAVY CHAIN, BETA-ACROSIN LIGHT CHAIN, BETA-L-FUCOSE, ...
Authors:Tranter, R., Read, J.A., Jones, R., Brady, R.L.
Deposit date:2000-08-07
Release date:2000-11-08
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Effector sites in the three-dimensional structure of mammalian sperm beta-acrosin.
Structure Fold.Des., 8, 2000
4AYD
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STRUCTURE OF A COMPLEX BETWEEN CCPS 6 AND 7 OF HUMAN COMPLEMENT FACTOR H AND NEISSERIA MENINGITIDIS FHBP VARIANT 1 R106A MUTANT
Descriptor:COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN, 1,2-ETHANEDIOL
Authors:Johnson, S., Tan, L., van der Veen, S., Caesar, J., Goicoechea De Jorge, E., Everett, R.J., Bai, X., Exley, R.M., Ward, P.N., Ruivo, N., Trivedi, K., Cumber, E., Jones, R., Newham, L., Staunton, D., Borrow, R., Pickering, M., Lea, S.M., Tang, C.M.
Deposit date:2012-06-20
Release date:2012-11-07
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules
Plos Pathog., 8, 2012
4AYE
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STRUCTURE OF A COMPLEX BETWEEN CCPS 6 AND 7 OF HUMAN COMPLEMENT FACTOR H AND NEISSERIA MENINGITIDIS FHBP VARIANT 1 E283AE304A MUTANT
Descriptor:COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN, 1,2-ETHANEDIOL
Authors:Johnson, S., Tan, L., van der Veen, S., Caesar, J., Goicoechea De Jorge, E., Everett, R.J., Bai, X., Exley, R.M., Ward, P.N., Ruivo, N., Trivedi, K., Cumber, E., Jones, R., Newham, L., Staunton, D., Borrow, R., Pickering, M., Lea, S.M., Tang, C.M.
Deposit date:2012-06-20
Release date:2012-11-07
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
4AYI
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STRUCTURE OF A COMPLEX BETWEEN CCPS 6 AND 7 OF HUMAN COMPLEMENT FACTOR H AND NEISSERIA MENINGITIDIS FHBP VARIANT 3 WILD TYPE
Descriptor:COMPLEMENT FACTOR H, LIPOPROTEIN GNA1870 CCOMPND 7, 1,2-ETHANEDIOL
Authors:Johnson, S., Tan, L., van der Veen, S., Caesar, J., Goicoechea De Jorge, E., Everett, R.J., Bai, X., Exley, R.M., Ward, P.N., Ruivo, N., Trivedi, K., Cumber, E., Jones, R., Newham, L., Staunton, D., Borrow, R., Pickering, M., Lea, S.M., Tang, C.M.
Deposit date:2012-06-21
Release date:2012-11-07
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.31 Å)
Cite:Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
4AYM
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STRUCTURE OF A COMPLEX BETWEEN CCPS 6 AND 7 OF HUMAN COMPLEMENT FACTOR H AND NEISSERIA MENINGITIDIS FHBP VARIANT 3 P106A MUTANT
Descriptor:COMPLEMENT FACTOR H, FACTOR H BINDING PROTEIN
Authors:Johnson, S., Tan, L., van der Veen, S., Caesar, J., Goicoechea De Jorge, E., Everett, R.J., Bai, X., Exley, R.M., Ward, P.N., Ruivo, N., Trivedi, K., Cumber, E., Jones, R., Newham, L., Staunton, D., Borrow, R., Pickering, M., Lea, S.M., Tang, C.M.
Deposit date:2012-06-21
Release date:2012-11-07
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (3 Å)
Cite:Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
4AYN
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STRUCTURE OF THE C-TERMINAL BARREL OF NEISSERIA MENINGITIDIS FHBP VARIANT 2
Descriptor:FACTOR H-BINDING PROTEIN, SULFATE ION
Authors:Johnson, S., Tan, L., van der Veen, S., Caesar, J., Goicoechea De Jorge, E., Everett, R.J., Bai, X., Exley, R.M., Ward, P.N., Ruivo, N., Trivedi, K., Cumber, E., Jones, R., Newham, L., Staunton, D., Borrow, R., Pickering, M., Lea, S.M., Tang, C.M.
Deposit date:2012-06-21
Release date:2012-11-07
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (2.06 Å)
Cite:Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
153D
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CRYSTAL STRUCTURE OF A MISPAIRED DODECAMER, D(CGAGAATTC(O6ME)GCG)2, CONTAINING A CARCINOGENIC O6-METHYLGUANINE
Descriptor:DNA (5'-D(*CP*GP*AP*GP*AP*AP*TP*TP*CP*(6OG)P*CP*G)-3')
Authors:Ginell, S.L., Vojtechovsky, J., Gaffney, B., Jones, R., Berman, H.M.
Deposit date:1993-12-16
Release date:1994-01-15
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structure of a mispaired dodecamer, d(CGAGAATTC(O6Me)GCG)2, containing a carcinogenic O6-methylguanine
Biochemistry, 33, 1994
1D6D
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SOLUTION DNA STRUCTURE CONTAINING (A-A)-T TRIADS INTERDIGITATED BETWEEN A-T BASE PAIRS AND GGGG TETRADS; NMR, 8 STRUCT.
Descriptor:5'-D(*AP*AP*GP*GP*TP*TP*TP*TP*AP*AP*GP*G)-3'
Authors:Kuryavyi, V.V., Kettani, A., Wang, W., Jones, R., Patel, D.J.
Deposit date:1999-10-13
Release date:2000-01-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A diamond-shaped zipper-like DNA architecture containing triads sandwiched between mismatches and tetrads.
J.Mol.Biol., 295, 2000
1D76
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CRYSTAL AND MOLECULAR STRUCTURE OF A DNA FRAGMENT CONTAINING A 2-AMINO ADENINE MODIFICATION: THE RELATIONSHIP BETWEEN CONFORMATION, PACKING, AND HYDRATION IN Z-DNA HEXAMERS
Descriptor:DNA (5'-D(*CP*GP*UP*(1AP)P*CP*G)-3')
Authors:Schneider, B., Ginell, S.L., Jones, R., Gaffney, B., Berman, H.M.
Deposit date:1992-05-19
Release date:1992-09-15
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Crystal and molecular structure of a DNA fragment containing a 2-aminoadenine modification: the relationship between conformation, packing, and hydration in Z-DNA hexamers.
Biochemistry, 31, 1992
1EEG
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A(GGGG)A HEXAD PAIRING ALIGMENT FOR THE D(G-G-A-G-G-A-G) SEQUENCE
Descriptor:DNA (5'-D(*GP*GP*AP*GP*GP*A)-3')
Authors:Kettani, A., Gorin, A., Majumdar, A., Hermann, T., Skripkin, E., Zhao, H., Jones, R., Patel, D.J.
Deposit date:2000-01-31
Release date:2000-04-02
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A dimeric DNA interface stabilized by stacked A.(G.G.G.G).A hexads and coordinated monovalent cations.
J.Mol.Biol., 297, 2000
1I34
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SOLUTION DNA QUADRUPLEX WITH DOUBLE CHAIN REVERSAL LOOP AND TWO DIAGONAL LOOPS CONNECTING GGGG TETRADS FLANKED BY G-(T-T) TRIAD AND T-T-T TRIPLE
Descriptor:5'-D(*GP*GP*TP*TP*TP*TP*GP*GP*CP*AP*GP*GP*GP*TP*TP*TP*TP*GP*GP*T)-3'
Authors:Kuryavyi, V., Majumdar, A., Shallop, A., Chernichenko, N., Skripkin, E., Jones, R., Patel, D.J.
Deposit date:2001-02-12
Release date:2001-06-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:A double chain reversal loop and two diagonal loops define the architecture of a unimolecular DNA quadruplex containing a pair of stacked G(syn)-G(syn)-G(anti)-G(anti) tetrads flanked by a G-(T-T) Triad and a T-T-T triple.
J.Mol.Biol., 310, 2001
210D
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CRYSTAL AND MOLECULAR STRUCTURE OF A NEW Z-DNA CRYSTAL FORM: D[CGT(2-NH2-A)CG] AND ITS PLATINATED DERIVATIVE
Descriptor:DNA (5'-D(*CP*GP*TP*(1AP)P*CP*G)-3'), SPERMINE
Authors:Parkinson, G.N., Arvantis, G.M., Lessinger, L., Ginell, S.L., Jones, R., Gaffney, B., Berman, H.M.
Deposit date:1995-06-13
Release date:1996-03-22
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Crystal and molecular structure of a new Z-DNA crystal form: d[CGT(2-NH2-A)CG] and its platinated derivative.
Biochemistry, 34, 1995
211D
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THE CRYSTAL AND MOLECULAR STRUCTURE OF A NEW Z-DNA CRYSTAL FORM: D[CGT(2-NH2-A) CG] AND ITS PLATINATED DERIVATIVE
Descriptor:DNA (5'-D(*CP*GP*TP*(1AP)P*CP*(PT(NH3)3)G)-3'), PLATINUM TRIAMINE ION, SPERMINE
Authors:Parkinson, G.N., Arvantis, G.M., Lessinger, L., Ginell, S.L., Jones, R., Gaffney, B., Berman, H.M.
Deposit date:1995-06-13
Release date:1996-03-22
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Crystal and molecular structure of a new Z-DNA crystal form: d[CGT(2-NH2-A)CG] and its platinated derivative.
Biochemistry, 34, 1995
218D
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THE STRUCTURE OF A NEW CRYSTAL FORM OF A DNA DODECAMER CONTAINING T.(O6ME)G BASE PAIRS
Descriptor:DNA (5'-D(*CP*GP*TP*GP*AP*AP*TP*TP*CP*(6OG)P*CP*G)-3')
Authors:Vojtechovsky, J., Eaton, M.D., Gaffney, B., Jones, R., Berman, H.M.
Deposit date:1995-07-18
Release date:1995-10-15
Last modified:2018-04-18
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure of a new crystal form of a DNA dodecamer containing T.(O6Me)G base pairs.
Biochemistry, 34, 1995
2KPC
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STRUCTURE DETERMINATION OF THE TOP-LOOP OF THE CONSERVED 3 TERMINAL SECONDARY STRUCTURE IN THE GENOME OF YFV
Descriptor:RNA (5'-R(*UP*GP*AP*GP*CP*AP*CP*AP*GP*UP*UP*UP*GP*CP*UP*CP*A)-3')
Authors:Lescrinier, E., Dyubankova, N., Nauwelaerts, K., Jones, R., Herdewijn, P.
Deposit date:2009-10-12
Release date:2010-06-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure Determination of the Top-Loop of the Conserved 3'-Terminal Secondary Structure in the Genome of Flaviviruses.
Chembiochem, 11, 2010
2KPD
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STRUCTURE DETERMINATION OF THE TOP-LOOP OF THE CONSERVED 3 TERMINAL SECONDARY STRUCTURE IN THE GENOME OF YFV-MUTANT
Descriptor:RNA (5'-R(*UP*GP*AP*GP*CP*UP*CP*AP*GP*UP*UP*UP*GP*CP*UP*CP*A)-3')
Authors:Lescrinier, E., Dyubankova, N., Nauwelaerts, K., Jones, R., Herdewijn, P.
Deposit date:2009-10-12
Release date:2010-06-30
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure Determination of the Top-Loop of the Conserved 3'-Terminal Secondary Structure in the Genome of Flaviviruses.
Chembiochem, 11, 2010
1A8N
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SOLUTION STRUCTURE OF A NA+ CATION STABILIZED DNA QUADRUPLEX CONTAINING G.G.G.G AND G.C.G.C TETRADS FORMED BY G-G-G-C REPEATS OBSERVED IN AAV AND HUMAN CHROMOSOME 19, NMR, 8 STRUCTURES
Descriptor:DNA QUADRUPLEX CONTAINING G.G.G.G AND G.C.G.C TETRADS
Authors:Kettani, A., Bouaziz, S., Gorin, A., Zhao, H., Jones, R., Patel, D.J.
Deposit date:1998-03-27
Release date:1998-10-14
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of a Na cation stabilized DNA quadruplex containing G.G.G.G and G.C.G.C tetrads formed by G-G-G-C repeats observed in adeno-associated viral DNA.
J.Mol.Biol., 282, 1998
2JPZ
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HUMAN TELOMERE DNA QUADRUPLEX STRUCTURE IN K+ SOLUTION HYBRID-2 FORM
Descriptor:DNA (26-MER)
Authors:Dai, J., Carver, M., Punchihewa, C., Jones, R., Yang, D.
Deposit date:2007-05-25
Release date:2007-12-04
Last modified:2014-10-01
Method:SOLUTION NMR
Cite:Structure of the Hybrid-2 type intramolecular human telomeric G-quadruplex in K+ solution: insights into structure polymorphism of the human telomeric sequence
Nucleic Acids Res., 35, 2007
2YBY
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STRUCTURE OF DOMAINS 6 AND 7 OF THE MOUSE COMPLEMENT REGULATOR FACTOR H
Descriptor:COMPLEMENT FACTOR H, 1,2-ETHANEDIOL
Authors:Everett, R.J., Caesar, J.J.E., Johnson, S.J., Tang, C.M., Lea, S.M.
Deposit date:2011-03-30
Release date:2012-04-18
Last modified:2015-03-25
Method:X-RAY DIFFRACTION (1.58 Å)
Cite:Design and Evaluation of Meningococcal Vaccines Through Structure-Based Modification of Host and Pathogen Molecules.
Plos Pathog., 8, 2012
6DI0
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CRYSTAL STRUCTURE OF BTK IN COMPLEX WITH FRAGMENT LIGAND
Descriptor:Tyrosine-protein kinase BTK, 6-(cyclohexylamino)pyridine-3-carboxamide
Authors:MOCHALKIN, I.
Deposit date:2018-05-22
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk.
Bioorg. Med. Chem. Lett., 28, 2018
6DI1
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CRYSTAL STRUCTURE OF BTK IN COMPLEX WITH COVALENT FRAGMENT LIGAND
Descriptor:Tyrosine-protein kinase BTK, 4-amino-2-[(3S)-3-(propanoylamino)pyrrolidin-1-yl]pyrimidine-5-carboxamide
Authors:Jiang, X.
Deposit date:2018-05-22
Release date:2018-10-17
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Discovery of a novel series of pyridine and pyrimidine carboxamides as potent and selective covalent inhibitors of Btk.
Bioorg. Med. Chem. Lett., 28, 2018
6N9P
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DISCOVERY OF AFFINITY-BASED PROBES FOR BTK OCCUPANCY ASSAY
Descriptor:Tyrosine-protein kinase BTK, N-(3-{[2-amino-3-(4-phenoxyphenyl)pyridin-4-yl]oxy}phenyl)propanamide
Authors:Mochalkin, I.
Deposit date:2018-12-03
Release date:2019-02-06
Method:X-RAY DIFFRACTION (2.23 Å)
Cite:Discovery of Affinity-Based Probes for Btk Occupancy Assays.
ChemMedChem, 14, 2019
2Y7L
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STRUCTURE OF N-TERMINAL DOMAIN OF CANDIDA ALBICANS ALS9-2 IN COMPLEX WITH HUMAN FIBRINOGEN GAMMA PEPTIDE
Descriptor:AGGLUTININ-LIKE ALS9 PROTEIN, FIBRINOGEN GAMMA CHAIN, ISOFORM CRA_A
Authors:Salgado, P.S., Cota, E.
Deposit date:2011-01-31
Release date:2011-10-05
Method:X-RAY DIFFRACTION (1.49 Å)
Cite:Structural Basis for the Broad Specificity to Host- Cell Ligands by the Pathogenic Fungus Candida Albicans.
Proc.Natl.Acad.Sci.USA, 108, 2011
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