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1HNG
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BU of 1hng by Molmil
CRYSTAL STRUCTURE AT 2.8 ANGSTROMS RESOLUTION OF A SOLUBLE FORM OF THE CELL ADHESION MOLECULE CD2
Descriptor: CD2
Authors:Jones, E.Y, Davis, S.J, Williams, A.F, Harlos, K, Stuart, D.I.
Deposit date:1994-08-10
Release date:1995-02-07
Last modified:2024-06-05
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure at 2.8 A resolution of a soluble form of the cell adhesion molecule CD2.
Nature, 360, 1992
1VCA
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BU of 1vca by Molmil
CRYSTAL STRUCTURE OF AN INTEGRIN-BINDING FRAGMENT OF VASCULAR CELL ADHESION MOLECULE-1 AT 1.8 ANGSTROMS RESOLUTION
Descriptor: HUMAN VASCULAR CELL ADHESION MOLECULE-1
Authors:Jones, E.Y, Harlos, K, Bottomley, M.J, Robinson, R.C, Driscoll, P.C, Edwards, R.M, Clements, J.M, Dudgeon, T.J, Stuart, D.I.
Deposit date:1995-03-21
Release date:1995-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of an integrin-binding fragment of vascular cell adhesion molecule-1 at 1.8 A resolution.
Nature, 373, 1995
7B50
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BU of 7b50 by Molmil
Notum complex with ARUK3003778
Descriptor: 3-(3,4-dichlorophenyl)sulfanyl-1$l^{4},2,7,8-tetrazabicyclo[4.3.0]nona-1(6),2,4,7-tetraen-9-one, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ...
Authors:Jones, E.Y, Fish, P.
Deposit date:2020-12-03
Release date:2022-01-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.33 Å)
Cite:Virtual Screening Directly Identifies New Fragment-Sized Inhibitors of Carboxylesterase Notum with Nanomolar Activity.
J.Med.Chem., 65, 2022
7B4X
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BU of 7b4x by Molmil
Notum complex with ARUK3002697
Descriptor: 1,2-ETHANEDIOL, 6-(4-methylphenyl)sulfanyl-2~{H}-[1,2,4]triazolo[4,3-b]pyridazin-3-one, DIMETHYL SULFOXIDE, ...
Authors:Jones, E.Y, Fish, P.
Deposit date:2020-12-02
Release date:2022-01-12
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.24 Å)
Cite:Structural Analysis and Development of Notum Fragment Screening Hits.
Acs Chem Neurosci, 13, 2022
1HNF
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BU of 1hnf by Molmil
CRYSTAL STRUCTURE OF THE EXTRACELLULAR REGION OF THE HUMAN CELL ADHESION MOLECULE CD2 AT 2.5 ANGSTROMS RESOLUTION
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CD2, SODIUM ION
Authors:Bodian, D.L, Jones, E.Y, Harlos, K, Stuart, D.I, Davis, S.J.
Deposit date:1994-08-10
Release date:1995-02-07
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of the extracellular region of the human cell adhesion molecule CD2 at 2.5 A resolution.
Structure, 2, 1994
4V2B
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BU of 4v2b by Molmil
rat Unc5D Ig domain 1
Descriptor: PROTEIN UNC5D
Authors:Seiradake, E, del Toro, D, Nagel, D, Cop, F, Haertl, R, Ruff, T, Seyit-Bremer, G, Harlos, K, Border, E.C, Acker-Palmer, A, Jones, E.Y, Klein, R.
Deposit date:2014-10-08
Release date:2014-11-05
Last modified:2015-07-22
Method:X-RAY DIFFRACTION (2 Å)
Cite:Flrt Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development
Neuron, 84, 2014
4UZ1
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BU of 4uz1 by Molmil
STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM III - 1.4A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, NOTUM, SULFATE ION
Authors:Zebisch, M, Jones, E.Y.
Deposit date:2014-09-04
Release date:2015-02-25
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Notum Deacylates Wnt Proteins to Suppress Signalling Activity.
Nature, 519, 2015
2X11
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BU of 2x11 by Molmil
Crystal structure of the complete EphA2 ectodomain in complex with ephrin A5 receptor binding domain
Descriptor: EPHRIN TYPE-A RECEPTOR 2, EPHRIN-A5
Authors:Seiradake, E, Harlos, K, Sutton, G, Aricescu, A.R, Jones, E.Y.
Deposit date:2009-12-21
Release date:2010-03-16
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (4.83 Å)
Cite:An Extracellular Steric Seeding Mechanism for Eph-Ephrin Signalling Platform Assembly
Nat.Struct.Mol.Biol., 17, 2010
6FKM
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BU of 6fkm by Molmil
Drosophila Plexin A in complex with Semaphorin 1b
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MIP07328p, Plexin A, ...
Authors:Rozbesky, D, Harlos, K, Jones, E.Y.
Deposit date:2018-01-24
Release date:2019-02-06
Last modified:2024-01-17
Method:X-RAY DIFFRACTION (2.96 Å)
Cite:Structural basis of semaphorin-plexin cis interaction.
Embo J., 2020
1GP3
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BU of 1gp3 by Molmil
Human IGF2R domain 11
Descriptor: CATION-INDEPENDENT MANNOSE-6-PHOSPHATE RECEPTOR
Authors:Brown, J, Esnouf, R.M, Jones, M.A, Linnell, J, Harlos, K, Hassan, A.B, Jones, E.Y.
Deposit date:2001-10-29
Release date:2002-02-28
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structure of a Functional Igf2R Fragment Determined from the Anomalous Scattering of Sulfur
Embo J., 21, 2002
5FN7
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BU of 5fn7 by Molmil
Crystal structure of human CD45 extracellular region, domains d1-d2
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, MERCURY (II) ION, RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE C
Authors:Chang, V.T, Fernandes, R.A, Ganzinger, K.A, Lee, S.F, Siebold, C, McColl, J, Jonsson, P, Palayret, M, Harlos, K, Coles, C.H, Jones, E.Y, Lui, Y, Huang, E, Gilbert, R.J.C, Klenerman, D, Aricescu, A.R, Davis, S.J.
Deposit date:2015-11-10
Release date:2016-03-23
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Initiation of T Cell Signaling by Cd45 Segregation at 'Close Contacts'.
Nat.Immunol., 17, 2016
5FWS
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BU of 5fws by Molmil
Wnt modulator Kremen crystal form I at 1.90A
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, KREMEN PROTEIN 1, ...
Authors:Zebisch, M, Jackson, V.A, Jones, E.Y.
Deposit date:2016-02-21
Release date:2016-07-20
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight Into Ternary Complex Formation with Lrp6 and Dickkopf
Structure, 24, 2016
4UFR
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BU of 4ufr by Molmil
Structure of the ectodomain of LGR5 in complex with R-spondin-2 (Fu1Fu2)
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5, ...
Authors:Zebisch, M, Jones, E.Y.
Deposit date:2015-03-18
Release date:2015-07-08
Last modified:2020-07-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal Structure of R-Spondin 2 in Complex with the Ectodomains of its Receptors Lgr5 and Znrf3.
J.Struct.Biol., 191, 2015
3GIV
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BU of 3giv by Molmil
Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance
Descriptor: Beta-2-microglobulin, HIV-1 peptide, HLA class I histocompatibility antigen, ...
Authors:Stewart-Jones, G, Iversen, A.K.N, Jones, E.Y.
Deposit date:2009-03-06
Release date:2009-06-30
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2 Å)
Cite:Antigen processing influences HIV-specific cytotoxic T lymphocyte immunodominance
Nat.Immunol., 10, 2009
3GJF
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BU of 3gjf by Molmil
Rational development of high-affinity T-cell receptor-like antibodies
Descriptor: Antibody heavy chain, Antibody light chain, Beta-2-microglobulin, ...
Authors:Stewart-Jones, G, Wadle, A, Hombach, A, Shenderov, E, Held, G, Fischer, E, Kleber, S, Stenner-Liewen, F, Bauer, S, McMichael, A, Knuth, A, Abken, H, Hombach, A.A, Cerundolo, V, Jones, E.Y, Renner, C.
Deposit date:2009-03-08
Release date:2009-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Rational development of high-affinity T-cell receptor-like antibodies
Proc.Natl.Acad.Sci.USA, 106, 2009
3GJE
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BU of 3gje by Molmil
Rational development of high-affinity T-cell receptor-like antibodies
Descriptor: Fab Heavy Chain, Fab Light Chain
Authors:Stewart-Jones, G, Wadle, A, Hombach, A, Shenderov, E, Held, G, Fischer, E, Kleber, S, Stenner-Liewen, F, Bauer, S, McMichael, A, Knuth, A, Abken, H, Hombach, A.A, Cerundolo, V, Jones, E.Y, Renner, C.
Deposit date:2009-03-08
Release date:2009-04-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Rational development of high-affinity T-cell receptor-like antibodies
Proc.Natl.Acad.Sci.USA, 106, 2009
1GZP
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BU of 1gzp by Molmil
CD1b in complex with GM2 ganglioside
Descriptor: B2-MICROGLOBULIN, DOCOSANE, DODECANE, ...
Authors:Gadola, S.D, Zaccai, N.R, Harlos, K, Shepherd, D, Ritter, G, Schmidt, R.R, Jones, E.Y, Cerundolo, V.
Deposit date:2002-05-24
Release date:2002-07-31
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains.
Nat. Immunol., 3, 2002
1GZQ
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BU of 1gzq by Molmil
CD1b in complex with Phophatidylinositol
Descriptor: 2-[(HYDROXY{[(2R,3R,5S,6R)-2,3,4,5,6-PENTAHYDROXYCYCLOHEXYL]OXY}PHOSPHORYL)OXY]-1-[(PALMITOYLOXY)METHYL]ETHYL HEPTADECANOATE, B2-MICROGLOBULIN, DOCOSANE, ...
Authors:Gadola, S.D, Zaccai, N.R, Harlos, K, Shepherd, D, Ritter, G, Schmidt, R.R, Jones, E.Y, Cerundolo, V.
Deposit date:2002-05-24
Release date:2002-07-31
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:Structure of Human Cd1B with Bound Ligands at 2.3 A, a Maze for Alkyl Chains
Nat.Immunol., 3, 2002
7QVZ
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BU of 7qvz by Molmil
ARUK3001043_Notum
Descriptor: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ...
Authors:Zhao, Y, Hillier, J, Willis, N.J, Mahy, W, Fish, P, Jones, E.Y.
Deposit date:2022-01-24
Release date:2022-05-04
Last modified:2024-01-31
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Structure Activity Analysis of Notum Fragment Screen Hits with Development
To Be Published
2YPK
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BU of 2ypk by Molmil
Structural features underlying T-cell receptor sensitivity to concealed MHC class I micropolymorphisms
Descriptor: BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, B-57 ALPHA CHAIN, ...
Authors:Stewart-Jones, G.B, Simpson, P, Van Der Merwe, P.A, Easterbrook, P, Mcmichael, A.J, Rowland-Jones, S.L, Jones, E.Y, Gillespie, G.M.
Deposit date:2012-10-30
Release date:2012-11-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural Features Underlying T-Cell Receptor Sensitivity to Concealed Mhc Class I Micropolymorphisms.
Proc.Natl.Acad.Sci.USA, 109, 2012
2YPL
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BU of 2ypl by Molmil
Structural features underlying T-cell receptor sensitivity to concealed MHC class I micropolymorphisms
Descriptor: AGA T-CELL RECEPTOR ALPHA CHAIN, AGA T-CELL RECEPTOR BETA CHAIN, BETA-2-MICROGLOBULIN, ...
Authors:Stewart-Jones, G.B, Simpson, P, van der Merwe, P.A, Easterbrook, P, McMichael, A.J, Rowland-Jones, S.L, Jones, E.Y, Gillespie, G.M.
Deposit date:2012-10-30
Release date:2012-11-28
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural Features Underlying T-Cell Receptor Sensitivity to Concealed Mhc Class I Micropolymorphisms.
Proc.Natl.Acad.Sci.USA, 109, 2012
7PJR
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BU of 7pjr by Molmil
Notum_ARUK3000438
Descriptor: 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-1,2,3-triazole, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ...
Authors:Vecchia, L, Zhao, Y, Fish, P, Jones, E.Y.
Deposit date:2021-08-24
Release date:2022-09-07
Last modified:2023-03-22
Method:X-RAY DIFFRACTION (1.51 Å)
Cite:Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
J.Med.Chem., 65, 2022
7PK3
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BU of 7pk3 by Molmil
Notum_ARUK3001185
Descriptor: 1-[2,4-bis(chloranyl)-3-(trifluoromethyl)phenyl]-1,2,3-triazole, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ...
Authors:Vecchia, L, Hillier, J, Zhao, Y, Fish, P, Jones, E.Y.
Deposit date:2021-08-25
Release date:2022-09-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.41 Å)
Cite:Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
J.Med.Chem., 65, 2022
7PKV
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BU of 7pkv by Molmil
Notum_Inhibitor ARUK3000223
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ...
Authors:Ruza, R, Zhao, Y, Fish, P, Jones, E.Y.
Deposit date:2021-08-26
Release date:2022-09-07
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (1.68 Å)
Cite:Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
J.Med.Chem., 65, 2022
1QFO
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BU of 1qfo by Molmil
N-TERMINAL DOMAIN OF SIALOADHESIN (MOUSE) IN COMPLEX WITH 3'SIALYLLACTOSE
Descriptor: N-acetyl-alpha-neuraminic acid, N-acetyl-alpha-neuraminic acid-(2-3)-beta-D-galactopyranose-(1-4)-alpha-D-glucopyranose, PROTEIN (SIALOADHESIN)
Authors:May, A.P, Robinson, R.C, Vinson, M, Crocker, P.R, Jones, E.Y.
Deposit date:1999-04-12
Release date:1999-04-16
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of the N-terminal domain of sialoadhesin in complex with 3' sialyllactose at 1.85 A resolution.
Mol.Cell, 1, 1998

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