Author results

1Y3A
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STRUCTURE OF G-ALPHA-I1 BOUND TO A GDP-SELECTIVE PEPTIDE PROVIDES INSIGHT INTO GUANINE NUCLEOTIDE EXCHANGE
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, KB752 peptide, ...
Authors:Johnston, C.A., Willard, F.S., Jezyk, M.R., Fredericks, Z., Bodor, E.T., Jones, M.B., Blaesius, R., Harden, T.K., Sondek, J., Watts, V.J., Ramer, J.K., Siderovski, D.P.
Deposit date:2004-11-24
Release date:2005-07-12
Last modified:2019-03-27
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of G-Alpha-I1 bound to a GDP-selective peptide provides insight into guanine nucleotide exchange
Structure, 7, 2005
2G83
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STRUCTURE OF ACTIVATED G-ALPHA-I1 BOUND TO A NUCLEOTIDE-STATE-SELECTIVE PEPTIDE: MINIMAL DETERMINANTS FOR RECOGNIZING THE ACTIVE FORM OF A G PROTEIN ALPHA SUBUNIT
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, KB-1753 phage display peptide, ...
Authors:Johnston, C.A., Ramer, J.K., Blaesius, R., Kuhlman, B., Arshavsky, V.Y., Siderovski, D.P.
Deposit date:2006-03-01
Release date:2006-10-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Minimal Determinants for Binding Activated Galpha from the Structure of a Galpha(i1)-Peptide Dimer.
Biochemistry, 45, 2006
3TVT
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STRUCTURAL BASIS FOR DISCS LARGE INTERACTION WITH PINS
Descriptor:Disks large 1 tumor suppressor protein, Partner of Inscuteable
Authors:Johnston, C.A., Doe, C.Q., Prehoda, K.E.
Deposit date:2011-09-20
Release date:2012-08-08
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural basis for Discs Large interaction with Pins
To be Published
3UMR
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CRYSTAL STRUCTURE OF THE G202D MUTANT OF HUMAN G-ALPHA-I1
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Johnston, C.A., Afshar, K., Snyder, J.T., Tall, G.G., Gonczy, P., Siderovski, D.P., Willard, F.S.
Deposit date:2011-11-14
Release date:2012-10-24
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Structural Determinants Underlying the Temperature-sensitive Nature of a G-alpha Mutant in Asymmetric Cell Division of Caenorhabditis elegans
To be Published
4F4J
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CONVERSION OF THE ENZYME GUANYLATE KINASE INTO A MITOTIC SPINDLE ORIENTING PROTEIN BY A SINGLE MUTATION THAT INHIBITS GMP- INDUCED CLOSING
Descriptor:Guanylate kinase, SULFATE ION
Authors:Johnston, C.A., Whitney, D., Volkman, B.F., Prehoda, K.E.
Deposit date:2012-05-10
Release date:2012-06-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Conversion of the enzyme guanylate kinase into a mitotic-spindle orienting protein by a single mutation that inhibits GMP-induced closing.
Proc.Natl.Acad.Sci.USA, 108, 2011
3UMS
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CRYSTAL STRUCTURE OF THE G202A MUTANT OF HUMAN G-ALPHA-I1
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, GUANOSINE-5'-DIPHOSPHATE, SULFATE ION, ...
Authors:Lambert, N.A., Johnston, C.A., Cappell, S.D., Kuravi, S., Kimple, A.J., Willard, F.S., Siderovski, D.P.
Deposit date:2011-11-14
Release date:2012-02-08
Method:X-RAY DIFFRACTION (2.343 Å)
Cite:Correction for Regulators of G-protein Signaling accelerate GPCR signaling kinetics and govern sensitivity solely by accelerating GTPase activity
Proc.Natl.Acad.Sci.USA, 2012
3D7M
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CRYSTAL STRUCTURE OF THE G PROTEIN FAST-EXCHANGE DOUBLE MUTANT I56C/Q333C
Descriptor:Guanine nucleotide-binding protein G(i), alpha-1 subunit, MAGNESIUM ION, ...
Authors:Funk, M.A., Preininger, A.M., Oldham, W.M., Meier, S.M., Hamm, H.E., Iverson, T.M.
Deposit date:2008-05-21
Release date:2009-03-03
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Helix dipole movement and conformational variability contribute to allosteric GDP release in Galphai subunits.
Biochemistry, 48, 2009
6KPC
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CRYSTAL STRUCTURE OF AN AGONIST BOUND GPCR
Descriptor:Cannabinoid receptor 2,Endolysin,Cannabinoid receptor 2, (6~{a}~{R},9~{R},10~{a}~{R})-9-(hydroxymethyl)-3-(8-isothiocyanato-2-methyl-octan-2-yl)-6,6-dimethyl-6~{a},7,8,9,10,10~{a}-hexahydrobenzo[c]chromen-1-ol
Authors:Li, X.T., Hua, T., Wu, L.J., Makriyannis, A., Wu, M., Liu, Z.J.
Deposit date:2019-08-15
Release date:2020-02-12
Last modified:2020-03-11
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures.
Cell, 180, 2020
6KPF
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CRYO-EM STRUCTURE OF A CLASS A GPCR WITH G PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Li, X.T., Hua, T., Wu, L.J., Makriyannis, A., Shen, L., Wang, Y.X., Liu, Z.J.
Deposit date:2019-08-15
Release date:2020-02-12
Last modified:2020-03-11
Method:ELECTRON MICROSCOPY (2.9 Å)
Cite:Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures.
Cell, 180, 2020
6KPG
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CRYO-EM STRUCTURE OF CB1-G PROTEIN COMPLEX
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ...
Authors:Hua, T., Li, X.T., Wu, L.J., Makriyannis, A., Wang, Y.X., Shen, L., Liu, Z.J.
Deposit date:2019-08-15
Release date:2020-02-12
Last modified:2020-03-11
Method:ELECTRON MICROSCOPY (3 Å)
Cite:Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-GiComplex Structures.
Cell, 180, 2020
2XTZ
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CRYSTAL STRUCTURE OF THE G ALPHA PROTEIN ATGPA1 FROM ARABIDOPSIS THALIANA
Descriptor:GUANINE NUCLEOTIDE-BINDING PROTEIN ALPHA-1 SUBUNIT, MAGNESIUM ION, 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, ...
Authors:Jones, J.C., Duffy, J.W., Machius, M., Temple, B.R.S., Dohlman, H.G., Jones, A.M.
Deposit date:2010-10-13
Release date:2011-02-16
Last modified:2019-05-15
Method:X-RAY DIFFRACTION (2.34 Å)
Cite:The Crystal Structure of a Self-Activating G Protein Alpha Subunit Reveals its Distinct Mechanism of Signal Initiation
Sci.Signal., 159, 2011
3QE0
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A GALPHA-I1 P-LOOP MUTATION PREVENTS TRANSITION TO THE ACTIVATED STATE
Descriptor:Guanine nucleotide-binding protein G(i) subunit alpha-1, KB752 peptide, MAGNESIUM ION, ...
Authors:Bosch, D.E., Willard, F.S., Kimple, A.J., Miley, M.J., Siderovski, D.P.
Deposit date:2011-01-19
Release date:2012-01-25
Last modified:2012-03-14
Method:X-RAY DIFFRACTION (3 Å)
Cite:A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8, 2012
167327
PDB entries from 2020-08-05