2G83

Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit

Summary for 2G83

DescriptorGuanine nucleotide-binding protein G(i), alpha-1 subunit, KB-1753 phage display peptide, TETRAFLUOROALUMINATE ION, ... (6 entities in total)
Functional Keywordsguanine-nucleotide binding protein, phage display peptide, signaling protein
Biological sourceHomo sapiens (human)
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Cellular locationNucleus (By similarity) P63096
Total number of polymer chains4
Total molecular weight75553.65
Authors
Johnston, C.A.,Ramer, J.K.,Blaesius, R.,Kuhlman, B.,Arshavsky, V.Y.,Siderovski, D.P. (deposition date: 2006-03-01, release date: 2006-10-10, Last modification date: 2011-07-13)
Primary citation
Johnston, C.A.,Lobanova, E.S.,Shavkunov, A.S.,Low, J.,Ramer, J.K.,Blaesius, R.,Fredericks, Z.,Willard, F.S.,Kuhlman, B.,Arshavsky, V.Y.,Siderovski, D.P.
Minimal Determinants for Binding Activated Galpha from the Structure of a Galpha(i1)-Peptide Dimer.
Biochemistry, 45:11390-11400, 2006
PubMed: 16981699 (PDB entries with the same primary citation)
DOI: 10.1021/bi0613832
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.8 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.297806.8%21.6%1.6%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
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