2G83

Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003924	molecular_function	GTPase activity
A	0005525	molecular_function	GTP binding
A	0007165	biological_process	signal transduction
A	0007186	biological_process	G protein-coupled receptor signaling pathway
A	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
A	0019001	molecular_function	guanyl nucleotide binding
A	0031683	molecular_function	G-protein beta/gamma-subunit complex binding
B	0003924	molecular_function	GTPase activity
B	0005525	molecular_function	GTP binding
B	0007165	biological_process	signal transduction
B	0007186	biological_process	G protein-coupled receptor signaling pathway
B	0007188	biological_process	adenylate cyclase-modulating G protein-coupled receptor signaling pathway
B	0019001	molecular_function	guanyl nucleotide binding
B	0031683	molecular_function	G-protein beta/gamma-subunit complex binding

Functional Information from PDB Data

site_id	AC1
Number of Residues	10
Details	BINDING SITE FOR RESIDUE ALF A 357

Chain	Residue
A	GLY42
A	MG356
A	GLU43
A	LYS46
A	ARG178
A	LYS180
A	THR181
A	GLY203
A	GLN204
A	GDP355

---

site_id	AC2
Number of Residues	13
Details	BINDING SITE FOR RESIDUE ALF B 359

Chain	Residue
B	HOH1
B	GLY42
B	GLU43
B	LYS46
B	ARG178
B	LYS180
B	THR181
B	VAL201
B	GLY202
B	GLY203
B	GLN204
B	GDP355
B	MG358

---

site_id	AC3
Number of Residues	6
Details	BINDING SITE FOR RESIDUE MG A 356

Chain	Residue
A	SER47
A	ARG178
A	VAL179
A	THR181
A	GDP355
A	ALF357

---

site_id	AC4
Number of Residues	5
Details	BINDING SITE FOR RESIDUE MG B 358

Chain	Residue
B	SER47
B	VAL179
B	THR181
B	GDP355
B	ALF359

---

site_id	AC5
Number of Residues	22
Details	BINDING SITE FOR RESIDUE GDP A 355

Chain	Residue
A	HOH2
A	HOH13
A	GLU43
A	SER44
A	GLY45
A	LYS46
A	SER47
A	THR48
A	SER151
A	LEU175
A	ARG176
A	THR177
A	ARG178
A	THR181
A	ASN269
A	LYS270
A	ASP272
A	LEU273
A	CYS325
A	ALA326
A	MG356
A	ALF357

---

site_id	AC6
Number of Residues	20
Details	BINDING SITE FOR RESIDUE GDP B 355

Chain	Residue
B	HOH1
B	GLU43
B	SER44
B	GLY45
B	LYS46
B	SER47
B	THR48
B	SER151
B	LEU175
B	ARG176
B	ARG178
B	THR181
B	ASN269
B	LYS270
B	ASP272
B	LEU273
B	CYS325
B	ALA326
B	MG358
B	ALF359

---

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q

Chain	Residue	Details
A	SER44
A	LYS270
B	SER44
B	LYS270

---

site_id	SWS_FT_FI2
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0

Chain	Residue	Details
A	THR48
A	THR182
B	THR48
B	THR182

---

site_id	SWS_FT_FI3
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q

Chain	Residue	Details
A	ALA152
B	ALA152

---

site_id	SWS_FT_FI4
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q

Chain	Residue	Details
A	ARG176
B	ARG176

---

site_id	SWS_FT_FI5
Number of Residues	2
Details	BINDING: BINDING => ECO:0000269|PubMed:21115486

Chain	Residue	Details
A	VAL201
B	VAL201

---

site_id	SWS_FT_FI6
Number of Residues	2
Details	BINDING: BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q

Chain	Residue	Details
A	THR327
B	THR327

---

site_id	SWS_FT_FI7
Number of Residues	2
Details	MOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250

Chain	Residue	Details
A	VAL179
B	VAL179

---

site_id	SWS_FT_FI8
Number of Residues	2
Details	MOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704

Chain	Residue	Details
A	ARG205
B	ARG205

---

Catalytic Information from CSA

site_id	CSA1
Number of Residues	4
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	THR181
A	GLN204
A	GLU43
A	ARG178

---

site_id	CSA2
Number of Residues	4
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	THR181
B	GLN204
B	GLU43
B	ARG178

---

site_id	CSA3
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
A	GLN204

---

site_id	CSA4
Number of Residues	1
Details	Annotated By Reference To The Literature 1ksj

Chain	Residue	Details
B	GLN204

---