2G83
Structure of activated G-alpha-i1 bound to a nucleotide-state-selective peptide: Minimal determinants for recognizing the active form of a G protein alpha subunit
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003924 | molecular_function | GTPase activity |
| A | 0005525 | molecular_function | GTP binding |
| A | 0007165 | biological_process | signal transduction |
| A | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| A | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| A | 0019001 | molecular_function | guanyl nucleotide binding |
| A | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
| B | 0003924 | molecular_function | GTPase activity |
| B | 0005525 | molecular_function | GTP binding |
| B | 0007165 | biological_process | signal transduction |
| B | 0007186 | biological_process | G protein-coupled receptor signaling pathway |
| B | 0007188 | biological_process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| B | 0019001 | molecular_function | guanyl nucleotide binding |
| B | 0031683 | molecular_function | G-protein beta/gamma-subunit complex binding |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE ALF A 357 |
| Chain | Residue |
| A | GLY42 |
| A | MG356 |
| A | GLU43 |
| A | LYS46 |
| A | ARG178 |
| A | LYS180 |
| A | THR181 |
| A | GLY203 |
| A | GLN204 |
| A | GDP355 |
| site_id | AC2 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE ALF B 359 |
| Chain | Residue |
| B | HOH1 |
| B | GLY42 |
| B | GLU43 |
| B | LYS46 |
| B | ARG178 |
| B | LYS180 |
| B | THR181 |
| B | VAL201 |
| B | GLY202 |
| B | GLY203 |
| B | GLN204 |
| B | GDP355 |
| B | MG358 |
| site_id | AC3 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MG A 356 |
| Chain | Residue |
| A | SER47 |
| A | ARG178 |
| A | VAL179 |
| A | THR181 |
| A | GDP355 |
| A | ALF357 |
| site_id | AC4 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MG B 358 |
| Chain | Residue |
| B | SER47 |
| B | VAL179 |
| B | THR181 |
| B | GDP355 |
| B | ALF359 |
| site_id | AC5 |
| Number of Residues | 22 |
| Details | BINDING SITE FOR RESIDUE GDP A 355 |
| Chain | Residue |
| A | HOH2 |
| A | HOH13 |
| A | GLU43 |
| A | SER44 |
| A | GLY45 |
| A | LYS46 |
| A | SER47 |
| A | THR48 |
| A | SER151 |
| A | LEU175 |
| A | ARG176 |
| A | THR177 |
| A | ARG178 |
| A | THR181 |
| A | ASN269 |
| A | LYS270 |
| A | ASP272 |
| A | LEU273 |
| A | CYS325 |
| A | ALA326 |
| A | MG356 |
| A | ALF357 |
| site_id | AC6 |
| Number of Residues | 20 |
| Details | BINDING SITE FOR RESIDUE GDP B 355 |
| Chain | Residue |
| B | HOH1 |
| B | GLU43 |
| B | SER44 |
| B | GLY45 |
| B | LYS46 |
| B | SER47 |
| B | THR48 |
| B | SER151 |
| B | LEU175 |
| B | ARG176 |
| B | ARG178 |
| B | THR181 |
| B | ASN269 |
| B | LYS270 |
| B | ASP272 |
| B | LEU273 |
| B | CYS325 |
| B | ALA326 |
| B | MG358 |
| B | ALF359 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21115486, ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q |
| Chain | Residue | Details |
| A | SER44 | |
| A | LYS270 | |
| B | SER44 | |
| B | LYS270 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:18434541, ECO:0000269|PubMed:22383884, ECO:0007744|PDB:3QE0 |
| Chain | Residue | Details |
| A | THR48 | |
| B | THR48 | |
| B | THR182 | |
| A | THR182 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:4G5Q |
| Chain | Residue | Details |
| A | ALA152 | |
| B | ALA152 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1KJY, ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:2XNS, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q |
| Chain | Residue | Details |
| A | ARG176 | |
| B | ARG176 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:21115486 |
| Chain | Residue | Details |
| A | VAL201 | |
| B | VAL201 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 2 |
| Details | BINDING: BINDING => ECO:0007744|PDB:1Y3A, ECO:0007744|PDB:2G83, ECO:0007744|PDB:2GTP, ECO:0007744|PDB:2IK8, ECO:0007744|PDB:2OM2, ECO:0007744|PDB:3ONW, ECO:0007744|PDB:3QE0, ECO:0007744|PDB:3QI2, ECO:0007744|PDB:3UMR, ECO:0007744|PDB:3UMS, ECO:0007744|PDB:4G5Q |
| Chain | Residue | Details |
| A | THR327 | |
| B | THR327 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 2 |
| Details | MOD_RES: ADP-ribosylarginine; by cholera toxin => ECO:0000250 |
| Chain | Residue | Details |
| A | VAL179 | |
| B | VAL179 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 2 |
| Details | MOD_RES: Deamidated glutamine; by Photorhabdus PAU_02230 => ECO:0000269|PubMed:24141704 |
| Chain | Residue | Details |
| A | ARG205 | |
| B | ARG205 |
