A Galpha-i1 P-loop mutation prevents transition to the activated state

Summary for 3QE0

Related3QI2 2OM2 1kjy 1Y3A
DescriptorGuanine nucleotide-binding protein G(i) subunit alpha-1, KB752 peptide, MAGNESIUM ION, ... (5 entities in total)
Functional Keywordskb752, ras-like domain, all-helical domain, arginine finger, signaling protein, lipoprotein, transducer, gtpase activity, gtp binding, nucleotide binding, adp-ribosylation
Biological sourceHomo sapiens (human)
Cellular locationNucleus (By similarity) P63096
Total number of polymer chains5
Total molecular weight117216.34
Bosch, D.E.,Willard, F.S.,Kimple, A.J.,Miley, M.J.,Siderovski, D.P. (deposition date: 2011-01-19, release date: 2012-01-25, Last modification date: 2012-03-14)
Primary citation
Bosch, D.E.,Willard, F.S.,Ramanujam, R.,Kimple, A.J.,Willard, M.D.,Naqvi, N.I.,Siderovski, D.P.
A P-loop Mutation in Galpha Subunits Prevents Transition to the Active State: Implications for G-protein Signaling in Fungal Pathogenesis
Plos Pathog., 8:e1002553-e1002553, 2012
PubMed: 22383884 (PDB entries with the same primary citation)
DOI: 10.1371/journal.ppat.1002553
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.292110.3%0.4%3.7%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution