3QE0
A Galpha-i1 P-loop mutation prevents transition to the activated state
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C (A, B, C) | Guanine nucleotide-binding protein G(i) subunit alpha-1 | polymer | 325 | 37246.4 | 3 | UniProt (P63096) Pfam (PF00503) | Homo sapiens (human) | Adenylate cyclase-inhibiting G alpha protein |
| 2 | D, E (G, F) | KB752 peptide | polymer | 16 | 2037.3 | 2 | |||
| 3 | F, H, J (A, B, C) | MAGNESIUM ION | non-polymer | 24.3 | 3 | Chemie (MG) | |||
| 4 | G, I, K (A, B, C) | GUANOSINE-5'-DIPHOSPHATE | non-polymer | 443.2 | 3 | Chemie (GDP) | |||
| 5 | L, M, N (A, B, C) | water | water | 18.0 | 12 | Chemie (HOH) |
Sequence modifications
A, B, C: 33 - 354 (UniProt: P63096)
| PDB | External Database | Details |
|---|---|---|
| Ser 30 | - | expression tag |
| Asn 31 | - | expression tag |
| Ala 32 | - | expression tag |
| Arg 42 | Gly 42 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 5 |
| Total formula weight | 115813.8 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1402.5 | |
| All* | Total formula weight | 117216.3 |
