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1E5L
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APO SACCHAROPINE REDUCTASE FROM MAGNAPORTHE GRISEA
Descriptor:SACCHAROPINE REDUCTASE
Authors:Johansson, E., Steffens, J.J., Lindqvist, Y., Schneider, G.
Deposit date:2000-07-27
Release date:2000-11-27
Last modified:2018-01-17
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal Structure of Saccharopine Reductase from Magnaporthe Grisea, an Enzyme of the Alpha-Aminoadipate Pathway of Lysine Biosynthesis
Structure, 8, 2000
1FF9
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APO SACCHAROPINE REDUCTASE
Descriptor:SACCHAROPINE REDUCTASE, SULFATE ION
Authors:Johansson, E., Steffens, J.J., Lindqvist, Y., Schneider, G.
Deposit date:2000-07-25
Release date:2000-11-08
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure of saccharopine reductase from Magnaporthe grisea, an enzyme of the alpha-aminoadipate pathway of lysine biosynthesis.
Structure Fold.Des., 8, 2000
1E5Q
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TERNARY COMPLEX OF SACCHAROPINE REDUCTASE FROM MAGNAPORTHE GRISEA, NADPH AND SACCHAROPINE
Descriptor:Saccharopine dehydrogenase [NADP(+), L-glutamate-forming], NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Johansson, E., Steffens, J.J., Lindqvist, Y., Schneider, G.
Deposit date:2000-07-28
Release date:2000-12-03
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal Structure of Saccharopine Reductase from Magnaporthe Grisea, an Enzyme of the Alpha-Aminoadipate Pathway of Lysine Biosynthesis
Structure, 8, 2000
1IDT
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STRUCTURAL STUDIES ON A PRODRUG-ACTIVATING SYSTEM-CB1954 AND FMN-DEPENDENT NITROREDUCTASE
Descriptor:MINOR FMN-DEPENDENT NITROREDUCTASE, FLAVIN MONONUCLEOTIDE, 5-(AZIRIDIN-1-YL)-2,4-DINITROBENZAMIDE
Authors:Johansson, E., Parkinson, G.N., Denny, W.A., Neidle, S.
Deposit date:2001-04-05
Release date:2003-09-16
Last modified:2018-12-12
Method:X-RAY DIFFRACTION (2 Å)
Cite:Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form.
J.Med.Chem., 46, 2003
1JTK
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CRYSTAL STRUCTURE OF CYTIDINE DEAMINASE FROM BACILLUS SUBTILIS IN COMPLEX WITH THE INHIBITOR TETRAHYDRODEOXYURIDINE
Descriptor:cytidine deaminase, ZINC ION, TETRAHYDRODEOXYURIDINE
Authors:Johansson, E., Mejlhede, N., Neuhard, J., Larsen, S.
Deposit date:2001-08-21
Release date:2002-04-10
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.04 Å)
Cite:Crystal structure of the tetrameric cytidine deaminase from Bacillus subtilis at 2.0 A resolution.
Biochemistry, 41, 2002
1OGH
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STRUCTURE OF THE BIFUNCTIONAL DCTP DEAMINASE-DUTPASE FROM METHANOCALDOCOCCUS JANNASCHII
Descriptor:BIFUNCTIONAL DEAMINASE/DIPHOSPHATASE
Authors:Johansson, E., Bjornberg, O., Nyman, P.O., Larsen, S.
Deposit date:2003-05-02
Release date:2003-06-05
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structure of the Bifunctional Dctp Deaminase-Dutpase from Methanocaldococcus Jannaschii and its Relation to Other Homotrimeric Dutpases
J.Biol.Chem., 278, 2003
1OO5
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STUDIES ON THE NITROREDUCTASE PRODRUG-ACTIVATING SYSTEM. CRYSTAL STRUCTURES OF THE ENZYME ACTIVE FORM AND COMPLEXES WITH THE INHIBITOR DICOUMAROL AND DINITROBENZAMIDE PRODRUGS
Descriptor:Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE
Authors:Johansson, E., Parkinson, G.N., Denny, W.A., Neidle, S.
Deposit date:2003-03-03
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
J.Med.Chem., 46, 2003
1OO6
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NITROREDUCTASE FROM E-COLI IN COMPLEX WITH THE DINITROBENZAMIDE PRODRUG SN23862
Descriptor:Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE, 5-[BIS-2(CHLORO-ETHYL)-AMINO]-2,4-DINTRO-BENZAMIDE
Authors:Johansson, E., Parkinson, G.N., Denny, W.A., Neidle, S.
Deposit date:2003-03-03
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
J.Med.Chem., 46, 2003
1OON
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NITROREDUCTASE FROM E-COLI IN COMPLEX WITH THE DINITROBENZAMIDE PRODRUG SN27217
Descriptor:Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE, 2,4-DINITRO,5-[BIS(2-BROMOETHYL)AMINO]-N-(2',3'-DIOXOPROPYL)BENZAMIDE
Authors:Johansson, E., Parkinson, G.N., Denny, W.A., Neidle, S.
Deposit date:2003-03-04
Release date:2003-04-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.49 Å)
Cite:Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
J.Med.Chem., 46, 2003
1OOQ
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NITROREDUCTASE FROM E-COLI IN COMPLEX WITH THE INHIBITOR DICOUMAROL
Descriptor:Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE, BISHYDROXY[2H-1-BENZOPYRAN-2-ONE,1,2-BENZOPYRONE]
Authors:Johansson, E., Parkinson, G.N., Denny, W.A., Neidle, S.
Deposit date:2003-03-04
Release date:2003-04-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
J.Med.Chem., 46, 2003
1UWZ
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BACILLUS SUBTILIS CYTIDINE DEAMINASE WITH AN ARG56 - ALA SUBSTITUTION
Descriptor:CYTIDINE DEAMINASE, TETRAHYDRODEOXYURIDINE, ZINC ION
Authors:Johansson, E., Neuhard, J., Willemoes, M., Larsen, S.
Deposit date:2004-02-18
Release date:2004-05-20
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural, Kinetic, and Mutational Studies of the Zinc Ion Environment in Tetrameric Cytidine Deaminase
Biochemistry, 43, 2004
1UX0
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BACILLUS SUBTILIS CYTIDINE DEAMINASE WITH AN ARG56 - GLN SUBSTITUTION
Descriptor:CYTIDINE DEAMINASE, TETRAHYDRODEOXYURIDINE, ZINC ION
Authors:Johansson, E., Neuhard, J., Willemoes, M., Larsen, S.
Deposit date:2004-02-18
Release date:2004-05-20
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structural, Kinetic, and Mutational Studies of the Zinc Ion Environment in Tetrameric Cytidine Deaminase
Biochemistry, 43, 2004
1UX1
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BACILLUS SUBTILIS CYTIDINE DEAMINASE WITH A CYS53HIS AND AN ARG56GLN SUBSTITUTION
Descriptor:CYTIDINE DEAMINASE, TETRAHYDRODEOXYURIDINE, ZINC ION, ...
Authors:Johansson, E., Neuhard, J., Willemoes, M., Larsen, S.
Deposit date:2004-02-18
Release date:2004-05-20
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.36 Å)
Cite:Structural, Kinetic, and Mutational Studies of the Zinc Ion Environment in Tetrameric Cytidine Deaminase
Biochemistry, 43, 2004
1XS1
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DCTP DEAMINASE FROM ESCHERICHIA COLI IN COMPLEX WITH DUTP
Descriptor:Deoxycytidine triphosphate deaminase, MAGNESIUM ION, DEOXYURIDINE-5'-TRIPHOSPHATE
Authors:Johansson, E., Fano, M., Bynck, J.H., Neuhard, J., Larsen, S., Sigurskjold, B.W., Christensen, U., Willemoes, M.
Deposit date:2004-10-18
Release date:2004-12-21
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes
J.Biol.Chem., 280, 2005
1XS4
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DCTP DEAMINASE FROM ESCHERICHIA COLI- E138A MUTANT ENZYME IN COMPLEX WITH DCTP
Descriptor:Deoxycytidine triphosphate deaminase, MAGNESIUM ION, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE
Authors:Johansson, E., Fano, M., Bynck, J.H., Neuhard, J., Larsen, S., Sigurskjold, B.W., Christensen, U., Willemoes, M.
Deposit date:2004-10-18
Release date:2004-12-21
Last modified:2018-08-08
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes
J.Biol.Chem., 280, 2005
1XS6
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DCTP DEAMINASE FROM ESCHERICHIA COLI. E138A MUTANT ENZYME IN COMPLEX WITH DUTP
Descriptor:Deoxycytidine triphosphate deaminase, MAGNESIUM ION, DEOXYURIDINE-5'-TRIPHOSPHATE
Authors:Johansson, E., Fano, M., Bynck, J.H., Neuhard, J., Larsen, S., Sigurskjold, B.W., Christensen, U., Willemoes, M.
Deposit date:2004-10-18
Release date:2004-12-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structures of dCTP deaminase from Escherichia coli with bound substrate and product: reaction mechanism and determinants of mono- and bifunctionality for a family of enzymes
J.Biol.Chem., 280, 2005
2J4H
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CRYSTAL STRUCTURE OF A H121A ESCHERICHIA COLI DCTP DEAMINASE MUTANT ENZYME
Descriptor:DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE, DEOXYCYTIDINE DIPHOSPHATE, MAGNESIUM ION
Authors:Johansson, E., Thymark, M., Bynck, J.H., Fanoe, M., Larsen, S., Willemoes, M.
Deposit date:2006-08-31
Release date:2007-08-07
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Regulation of Dctp Deaminase from Escherichia Coli by Nonallosteric Dttp Binding to an Inactive Form of the Enzyme
FEBS J., 274, 2007
2J4Q
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CRYSTAL STRUCTURE OF A E138A ESCHERICHIA COLI DCTP DEAMINASE MUTANT ENZYME IN COMPLEX WITH DTTP
Descriptor:DEOXYCYTIDINE TRIPHOSPHATE DEAMINASE, THYMIDINE-5'-DIPHOSPHATE, THYMIDINE-5'-TRIPHOSPHATE, ...
Authors:Johansson, E., Thymark, M., Bynck, J.H., Fanoe, M., Larsen, S., Willemoes, M.
Deposit date:2006-09-05
Release date:2007-08-07
Last modified:2019-03-06
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Regulation of Dctp Deaminase from Escherichia Coli by Nonallosteric Dttp Binding to an Inactive Form of the Enzyme
FEBS J., 274, 2007
5II0
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CRYSTAL STRUCTURE OF THE HUMAN CALCITONIN RECEPTOR ECTODOMAIN IN COMPLEX WITH A TRUNCATED SALMON CALCITONIN ANALOGUE
Descriptor:Calcitonin receptor, Calcitonin, SODIUM ION, ...
Authors:Johansson, E., Reedtz-Runge, S.
Deposit date:2016-03-01
Release date:2016-05-11
Last modified:2016-07-06
Method:X-RAY DIFFRACTION (2.097 Å)
Cite:Type II Turn of Receptor-bound Salmon Calcitonin Revealed by X-ray Crystallography.
J.Biol.Chem., 291, 2016
6S34
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ZINC FREE, DIMERIC HUMAN INSULIN DETERMINED TO 1.35 ANGSTROM RESOLUTION
Descriptor:Insulin, 1,2-ETHANEDIOL
Authors:Johansson, E.
Deposit date:2019-06-24
Release date:2019-07-03
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Zinc free, dimeric human insulin determined to 1.35 Angstrom resolution
To Be Published
5J4Q
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ALPHA-CHYMOTRYPSIN FROM BOVINE PANCREAS IN COMPLEX WITH BOWMAN-BIRK INHIBITOR FROM SOYBEAN
Descriptor:Chymotrypsinogen A, Bowman-Birk type proteinase inhibitor
Authors:Johansson, E., Tornoee, C.W.
Deposit date:2016-04-01
Release date:2017-04-12
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (2.303 Å)
Cite:Divergent Protein Synthesis of Bowman-Birk Protease Inhibitors, their Hydrodynamic Behavior and Co-crystallization with alpha-Chymotrypsin
Synlett, 2017
5J4S
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ALPHA-CHYMOTRYPSIN FROM BOVINE PANCREAS IN COMPLEX WITH A MODIFIED BOWMAN-BIRK INHIBITOR FROM SOYBEAN
Descriptor:Chymotrypsinogen A, Bowman-Birk type proteinase inhibitor
Authors:Johansson, E., Tornoee, C.W.
Deposit date:2016-04-01
Release date:2017-04-12
Last modified:2017-06-07
Method:X-RAY DIFFRACTION (2.103 Å)
Cite:Divergent Protein Synthesis of Bowman-Birk Protease Inhibitors, their Hydrodynamic Behavior and Co-crystallization with alpha-Chymotrypsin
Synlett, 2017
1FTD
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5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'-SYMMETRIC BIS-BENZIMIDAZOLE COMPLEX
Descriptor:DNA (5'-D(*CP*GP*CP*GP*AP*AP*TP*TP*CP*GP*CP*G)-3'), MAGNESIUM ION, [3-(4-{2'-[4-(3-DIMETHYLAMINO-PROPOXY)-PHENYL]-3H,3'H-[5,5']BIBENZOIMIDAZOLYL-2-YL}-PHENOXY)-PROPYL]-DIMETHYL-AMINE
Authors:Mann, J., Baron, A., Opoku-Boahen, Y., Johansson, E., Parkinson, G., Kelland, L.R., Neidle, S.
Deposit date:2000-09-12
Release date:2001-02-26
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2 Å)
Cite:A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity.
J.Med.Chem., 44, 2001
1QHW
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PURPLE ACID PHOSPHATASE FROM RAT BONE
Descriptor:PROTEIN (PURPLE ACID PHOSPHATASE), N-ACETYL-D-GLUCOSAMINE, FE (III) ION, ...
Authors:Lindqvist, Y., Johansson, E., Kaija, H., Vihko, P., Schneider, G.
Deposit date:1999-03-26
Release date:1999-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Three-dimensional structure of a mammalian purple acid phosphatase at 2.2 A resolution with a mu-(hydr)oxo bridged di-iron center.
J.Mol.Biol., 291, 1999
1U9Y
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CRYSTAL STRUCTURE OF PHOSPHORIBOSYL DIPHOSPHATE SYNTHASE FROM METHANOCALDOCOCCUS JANNASCHII
Descriptor:Ribose-phosphate pyrophosphokinase
Authors:Kadziola, A., Johansson, E., Jepsen, C.H., McGuire, J., Larsen, S., Hove-Jensen, B.
Deposit date:2004-08-11
Release date:2005-08-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.65 Å)
Cite:Novel class III phosphoribosyl diphosphate synthase: structure and properties of the tetrameric, phosphate-activated, non-allosterically inhibited enzyme from Methanocaldococcus jannaschii
J.Mol.Biol., 354, 2005
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