Nitroreductase from e-coli in complex with the dinitrobenzamide prodrug SN27217

Summary for 1OON
Related1DS7 1IDT 1OO5 1OO6 1OOQ
DescriptorOxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE, 2,4-DINITRO,5-[BIS(2-BROMOETHYL)AMINO]-N-(2',3'-DIOXOPROPYL)BENZAMIDE, ... (4 entities in total)
Functional Keywordsnad(p)h-quinone reductase, fmn, nitroreductase, flavoprotein, sn27217, oxidoreductase
Biological sourceEscherichia coli
Total number of polymer chains2
Total formula weight49297.14
Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. (deposition date: 2003-03-04, release date: 2003-04-08, Last modification date: 2011-07-13)
Primary citationDenny, W.A.,Johansson, E.,Neidle, S.,Parkinson, G.N.
Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form
J.Med.Chem., 46:4009-4020, 2003
PubMed: 12954054
DOI: 110.1021/jm030843b
PDB entries with the same primary citation
Experimental method
Structure validation
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PDB entries from 2021-06-16