1OO6
Nitroreductase from e-coli in complex with the dinitrobenzamide prodrug SN23862
Summary for 1OO6
Entry DOI | 10.2210/pdb1oo6/pdb |
Related | 1IDT 1OO5 1OON 1OOQ |
Descriptor | Oxygen-insensitive NAD(P)H nitroreductase, FLAVIN MONONUCLEOTIDE, 5-[BIS-2(CHLORO-ETHYL)-AMINO]-2,4-DINTRO-BENZAMIDE, ... (4 entities in total) |
Functional Keywords | nad(p)h-quinone reductase, fmn, nitroreductase, flavoprotein, sn23862, oxidoreductase |
Biological source | Escherichia coli |
Total number of polymer chains | 2 |
Total formula weight | 49489.34 |
Authors | Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. (deposition date: 2003-03-03, release date: 2003-04-08, Last modification date: 2023-08-16) |
Primary citation | Johansson, E.,Parkinson, G.N.,Denny, W.A.,Neidle, S. Studies on the Nitroreductase Prodrug-Activating System. Crystal Structures of Complexes with the Inhibitor Dicoumarol and Dinitrobenzamide Prodrugs and of the Enzyme Active Form J.Med.Chem., 46:4009-4020, 2003 Cited by PubMed: 12954054DOI: 10.1021/jm030843b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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