6QIO

Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the human growth hormone derivative somapacitan

Summary for 6QIO

Entry DOI	10.2210/pdb6qio/pdb
Descriptor	Serum albumin, IgG receptor FcRn large subunit p51, Beta-2-microglobulin, ... (7 entities in total)
Functional Keywords	complex, albumin binding, long-acting growth hormone, somapacitan, hormone
Biological source	Homo sapiens (human) More
Total number of polymer chains	3
Total formula weight	111088.23
Authors	Johansson, E. (deposition date: 2019-01-21, release date: 2020-02-05, Last modification date: 2024-01-24)
Primary citation	Johansson, E.,Nielsen, A.D.,Demuth, H.,Wiberg, C.,Schjodt, C.B.,Huang, T.,Chen, J.,Jensen, S.,Petersen, J.,Thygesen, P. Identification of Binding Sites on Human Serum Albumin for Somapacitan, a Long-Acting Growth Hormone Derivative. Biochemistry, 59:1410-1419, 2020 Cited by PubMed: 32208682 DOI: 10.1021/acs.biochem.0c00019 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation