6QIO
Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the human growth hormone derivative somapacitan
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0003677 | molecular_function | DNA binding |
| A | 0005504 | molecular_function | fatty acid binding |
| A | 0005507 | molecular_function | copper ion binding |
| A | 0005515 | molecular_function | protein binding |
| A | 0005576 | cellular_component | extracellular region |
| A | 0005615 | cellular_component | extracellular space |
| A | 0005634 | cellular_component | nucleus |
| A | 0005737 | cellular_component | cytoplasm |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005788 | cellular_component | endoplasmic reticulum lumen |
| A | 0005794 | cellular_component | Golgi apparatus |
| A | 0008289 | molecular_function | lipid binding |
| A | 0009267 | biological_process | cellular response to starvation |
| A | 0015643 | molecular_function | toxic substance binding |
| A | 0016209 | molecular_function | antioxidant activity |
| A | 0019825 | molecular_function | oxygen binding |
| A | 0030170 | molecular_function | pyridoxal phosphate binding |
| A | 0031093 | cellular_component | platelet alpha granule lumen |
| A | 0032991 | cellular_component | protein-containing complex |
| A | 0042802 | molecular_function | identical protein binding |
| A | 0046872 | molecular_function | metal ion binding |
| A | 0051087 | molecular_function | protein-folding chaperone binding |
| A | 0051902 | biological_process | negative regulation of mitochondrial depolarization |
| A | 0070062 | cellular_component | extracellular exosome |
| A | 0072562 | cellular_component | blood microparticle |
| A | 0072732 | biological_process | cellular response to calcium ion starvation |
| A | 0098869 | biological_process | cellular oxidant detoxification |
| A | 0140272 | molecular_function | exogenous protein binding |
| A | 1903981 | molecular_function | enterobactin binding |
| C | 0000139 | cellular_component | Golgi membrane |
| C | 0001913 | biological_process | T cell mediated cytotoxicity |
| C | 0001916 | biological_process | positive regulation of T cell mediated cytotoxicity |
| C | 0002237 | biological_process | response to molecule of bacterial origin |
| C | 0002474 | biological_process | antigen processing and presentation of peptide antigen via MHC class I |
| C | 0002481 | biological_process | antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent |
| C | 0002502 | biological_process | peptide antigen assembly with MHC class I protein complex |
| C | 0002503 | biological_process | peptide antigen assembly with MHC class II protein complex |
| C | 0002726 | biological_process | positive regulation of T cell cytokine production |
| C | 0005198 | molecular_function | structural molecule activity |
| C | 0005515 | molecular_function | protein binding |
| C | 0005576 | cellular_component | extracellular region |
| C | 0005615 | cellular_component | extracellular space |
| C | 0005765 | cellular_component | lysosomal membrane |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005788 | cellular_component | endoplasmic reticulum lumen |
| C | 0005794 | cellular_component | Golgi apparatus |
| C | 0005829 | cellular_component | cytosol |
| C | 0005886 | cellular_component | plasma membrane |
| C | 0005925 | cellular_component | focal adhesion |
| C | 0006826 | biological_process | iron ion transport |
| C | 0006879 | biological_process | intracellular iron ion homeostasis |
| C | 0006955 | biological_process | immune response |
| C | 0007608 | biological_process | sensory perception of smell |
| C | 0007611 | biological_process | learning or memory |
| C | 0009897 | cellular_component | external side of plasma membrane |
| C | 0009986 | cellular_component | cell surface |
| C | 0010977 | biological_process | negative regulation of neuron projection development |
| C | 0012507 | cellular_component | ER to Golgi transport vesicle membrane |
| C | 0016020 | cellular_component | membrane |
| C | 0019885 | biological_process | antigen processing and presentation of endogenous peptide antigen via MHC class I |
| C | 0019886 | biological_process | antigen processing and presentation of exogenous peptide antigen via MHC class II |
| C | 0023026 | molecular_function | MHC class II protein complex binding |
| C | 0030670 | cellular_component | phagocytic vesicle membrane |
| C | 0031901 | cellular_component | early endosome membrane |
| C | 0031902 | cellular_component | late endosome membrane |
| C | 0031905 | cellular_component | early endosome lumen |
| C | 0032092 | biological_process | positive regulation of protein binding |
| C | 0033077 | biological_process | T cell differentiation in thymus |
| C | 0034756 | biological_process | regulation of iron ion transport |
| C | 0035580 | cellular_component | specific granule lumen |
| C | 0042026 | biological_process | protein refolding |
| C | 0042605 | molecular_function | peptide antigen binding |
| C | 0042612 | cellular_component | MHC class I protein complex |
| C | 0042613 | cellular_component | MHC class II protein complex |
| C | 0042802 | molecular_function | identical protein binding |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0042824 | cellular_component | MHC class I peptide loading complex |
| C | 0045646 | biological_process | regulation of erythrocyte differentiation |
| C | 0048260 | biological_process | positive regulation of receptor-mediated endocytosis |
| C | 0050680 | biological_process | negative regulation of epithelial cell proliferation |
| C | 0050768 | biological_process | negative regulation of neurogenesis |
| C | 0050778 | biological_process | positive regulation of immune response |
| C | 0050870 | biological_process | positive regulation of T cell activation |
| C | 0051289 | biological_process | protein homotetramerization |
| C | 0055038 | cellular_component | recycling endosome membrane |
| C | 0060586 | biological_process | multicellular organismal-level iron ion homeostasis |
| C | 0070062 | cellular_component | extracellular exosome |
| C | 0071281 | biological_process | cellular response to iron ion |
| C | 0071283 | biological_process | cellular response to iron(III) ion |
| C | 0071316 | biological_process | cellular response to nicotine |
| C | 1900121 | biological_process | negative regulation of receptor binding |
| C | 1900122 | biological_process | positive regulation of receptor binding |
| C | 1904434 | biological_process | positive regulation of ferrous iron binding |
| C | 1904437 | biological_process | positive regulation of transferrin receptor binding |
| C | 1904724 | cellular_component | tertiary granule lumen |
| C | 1990000 | biological_process | amyloid fibril formation |
| C | 1990712 | cellular_component | HFE-transferrin receptor complex |
| C | 2000774 | biological_process | positive regulation of cellular senescence |
| C | 2000978 | biological_process | negative regulation of forebrain neuron differentiation |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 7 |
| Details | binding site for residue MES A 601 |
| Chain | Residue |
| A | LEU387 |
| A | ILE388 |
| A | ASN391 |
| A | TYR411 |
| A | VAL433 |
| A | ARG485 |
| A | SER489 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | binding site for residue CYS B 301 |
| Chain | Residue |
| B | CYS48 |
| C | SER52 |
| C | ASP53 |
| C | HOH211 |
| B | GLN34 |
| B | SER37 |
| site_id | AC3 |
| Number of Residues | 15 |
| Details | binding site for residue JG5 A 603 |
| Chain | Residue |
| A | PHE228 |
| A | SER232 |
| A | VAL325 |
| A | LEU347 |
| A | ALA350 |
| A | LYS351 |
| A | SER480 |
| A | LEU481 |
| B | GLY222 |
| B | GLN223 |
| B | LEU240 |
| B | THR241 |
| B | HOH449 |
| A | HOH727 |
| A | HOH814 |
Functional Information from PROSITE/UniProt
| site_id | PS00212 |
| Number of Residues | 25 |
| Details | ALBUMIN_1 Albumin domain signature. YkaafteCCqaAdkaaCLlpkldeL |
| Chain | Residue | Details |
| A | TYR161-LEU185 | |
| A | TYR353-PHE377 | |
| A | PHE551-LEU575 |
| site_id | PS00290 |
| Number of Residues | 7 |
| Details | IG_MHC Immunoglobulins and major histocompatibility complex proteins signature. YCCIVQH |
| Chain | Residue | Details |
| B | TYR250-HIS256 | |
| C | TYR78-HIS84 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1 |
| Details | MOD_RES: Pyrrolidone carboxylic acid; in form pI 5.3 => ECO:0000269|PubMed:7554280 |
| Chain | Residue | Details |
| C | GLN2 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (Glc) (glycation) isoleucine; in hemodialysis-associated amyloidosis => ECO:0000269|PubMed:7918443 |
| Chain | Residue | Details |
| C | ILE1 | |
| A | ASP13 | |
| A | GLU244 | |
| A | GLU252 | |
| A | ASP255 | |
| A | ASP259 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 6 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:7918443 |
| Chain | Residue | Details |
| C | LYS19 | |
| C | LYS41 | |
| C | LYS48 | |
| C | LYS58 | |
| C | LYS91 | |
| C | LYS94 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 1 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:656055 |
| Chain | Residue | Details |
| A | LYS240 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 37 |
| Details | SITE: Not glycated => ECO:0000269|PubMed:15047055 |
| Chain | Residue | Details |
| A | LYS4 | |
| A | LYS174 | |
| A | LYS181 | |
| A | LYS190 | |
| A | LYS195 | |
| A | LYS205 | |
| A | LYS212 | |
| A | LYS240 | |
| A | LYS262 | |
| A | LYS274 | |
| A | LYS286 | |
| A | LYS20 | |
| A | LYS359 | |
| A | LYS372 | |
| A | LYS389 | |
| A | LYS402 | |
| A | LYS414 | |
| A | LYS432 | |
| A | LYS436 | |
| A | LYS466 | |
| A | LYS475 | |
| A | LYS500 | |
| A | LYS41 | |
| A | LYS519 | |
| A | LYS524 | |
| A | LYS538 | |
| A | LYS541 | |
| A | LYS557 | |
| A | LYS560 | |
| A | LYS564 | |
| A | LYS574 | |
| A | LYS64 | |
| A | LYS73 | |
| A | LYS93 | |
| A | LYS106 | |
| A | LYS136 | |
| A | LYS159 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 1 |
| Details | SITE: Aspirin-acetylated lysine |
| Chain | Residue | Details |
| A | LYS199 |
| site_id | SWS_FT_FI7 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039 |
| Chain | Residue | Details |
| A | SER5 |
| site_id | SWS_FT_FI8 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039, ECO:0007744|PubMed:18318008, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER58 |
| site_id | SWS_FT_FI9 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine; by FAM20C => ECO:0000269|PubMed:26091039, ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER65 |
| site_id | SWS_FT_FI10 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphothreonine; by FAM20C => ECO:0000269|PubMed:26091039 |
| Chain | Residue | Details |
| A | THR83 |
| site_id | SWS_FT_FI11 |
| Number of Residues | 4 |
| Details | MOD_RES: N6-succinyllysine => ECO:0000250|UniProtKB:P07724 |
| Chain | Residue | Details |
| A | LYS205 | |
| A | LYS436 | |
| A | LYS519 | |
| A | LYS564 |
| site_id | SWS_FT_FI12 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0000250|UniProtKB:P07724 |
| Chain | Residue | Details |
| A | SER273 |
| site_id | SWS_FT_FI13 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | SER419 |
| site_id | SWS_FT_FI14 |
| Number of Residues | 2 |
| Details | MOD_RES: Phosphothreonine => ECO:0007744|PubMed:19690332 |
| Chain | Residue | Details |
| A | ALA420 | |
| A | THR422 |
| site_id | SWS_FT_FI15 |
| Number of Residues | 1 |
| Details | MOD_RES: Phosphoserine => ECO:0007744|PubMed:24275569 |
| Chain | Residue | Details |
| A | SER489 |
| site_id | SWS_FT_FI16 |
| Number of Residues | 1 |
| Details | MOD_RES: N6-methyllysine; alternate => ECO:0007744|PubMed:24129315 |
| Chain | Residue | Details |
| A | LYS534 |
| site_id | SWS_FT_FI17 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:3759977 |
| Chain | Residue | Details |
| A | LYS12 | |
| A | LYS281 | |
| A | LYS317 | |
| A | LYS439 |
| site_id | SWS_FT_FI18 |
| Number of Residues | 13 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:15047055 |
| Chain | Residue | Details |
| A | LYS51 | |
| A | LYS444 | |
| A | LYS536 | |
| A | LYS545 | |
| A | LYS573 | |
| A | LYS137 | |
| A | LYS162 | |
| A | LYS225 | |
| A | LYS276 | |
| A | LYS313 | |
| A | LYS323 | |
| A | LYS378 | |
| A | LYS413 |
| site_id | SWS_FT_FI19 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; in vitro => ECO:0000269|PubMed:3759977, ECO:0000269|PubMed:6853480 |
| Chain | Residue | Details |
| A | LYS199 |
| site_id | SWS_FT_FI20 |
| Number of Residues | 2 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:15047055, ECO:0000269|PubMed:3759977 |
| Chain | Residue | Details |
| A | LYS233 | |
| A | LYS351 |
| site_id | SWS_FT_FI21 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; in variant Redhill |
| Chain | Residue | Details |
| A | ASN318 |
| site_id | SWS_FT_FI22 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine; in variant Casebrook |
| Chain | Residue | Details |
| A | ASP494 |
| site_id | SWS_FT_FI23 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine => ECO:0000269|PubMed:15047055, ECO:0000269|PubMed:3759977, ECO:0000269|PubMed:6706980, ECO:0000269|PubMed:6853480 |
| Chain | Residue | Details |
| A | LYS525 |
| site_id | SWS_FT_FI24 |
| Number of Residues | 1 |
| Details | CARBOHYD: N-linked (Glc) (glycation) lysine; alternate => ECO:0000269|PubMed:3759977 |
| Chain | Residue | Details |
| A | LYS534 |
