6QIO
Ternary complex of FcRn ectodomain, FcRn binding optimised human serum albumin and the human growth hormone derivative somapacitan
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Serum albumin | polymer | 585 | 66473.1 | 1 | UniProt (P02768) Pfam (PF00273) In PDB | Homo sapiens (human) | |
2 | B | IgG receptor FcRn large subunit p51 | polymer | 274 | 30408.1 | 1 | UniProt (P55899) Pfam (PF00129) Pfam (PF07654) In PDB | Homo sapiens (human) | FcRn,IgG Fc fragment receptor transporter alpha chain,Neonatal Fc receptor |
3 | C | Beta-2-microglobulin | polymer | 105 | 12577.0 | 1 | UniProt (P61769) Pfam (PF07654) In PDB | Homo sapiens (human) | |
4 | A | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID | non-polymer | 195.2 | 1 | Chemie (MES) | |||
5 | A, B | CYSTEINE | non-polymer | 121.2 | 2 | Chemie (CYS) | |||
6 | A | Somapacitan | non-polymer | 1192.4 | 1 | Chemie (JG5) | |||
7 | water | water | 18.0 | 878 | Chemie (HOH) |
Sequence modifications
A: 1 - 585 (UniProt: P02768)
C: 1 - 99 (UniProt: P61769)
PDB | External Database | Details |
---|---|---|
Met 418 | Val 442 | engineered mutation |
Ala 420 | Thr 444 | engineered mutation |
Gly 505 | Glu 529 | engineered mutation |
Ala 547 | Val 571 | engineered mutation |
PDB | External Database | Details |
---|---|---|
His 100 | - | expression tag |
His 101 | - | expression tag |
His 102 | - | expression tag |
His 103 | - | expression tag |
His 104 | - | expression tag |
His 105 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 3 |
Total formula weight | 109458.3 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1629.9 | |
All* | Total formula weight | 111088.2 |