Author results

2J1W
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HUMAN P53 CORE DOMAIN MUTANT M133L-V143A-V203A-N239Y-N268D
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2006-08-15
Release date:2006-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J1X
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HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-Y220C-N239Y-N268D
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2006-08-15
Release date:2006-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J1Y
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HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-G245S-N268D
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION, CALCIUM ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2006-08-15
Release date:2006-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J1Z
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HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-F270L
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2006-08-15
Release date:2006-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J20
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HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-R273C
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION, SULFATE ION
Authors:Joerger, A.C., Ang, H.C., Fersht, A.R.
Deposit date:2006-08-15
Release date:2006-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
2J21
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HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-R282W
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2006-08-15
Release date:2006-09-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs.
Proc.Natl.Acad.Sci.USA, 103, 2006
1E46
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L-FUCULOSE 1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI MUTANT E73S
Descriptor:L-FUCULOSE 1-PHOSPHATE ALDOLASE, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Joerger, A.C., Schulz, G.E.
Deposit date:2000-06-30
Release date:2000-11-06
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Structures of L-Fuculose-1-Phosphate Aldolase Mutants Outlining Motions During Catalysis
J.Mol.Biol., 303, 2000
1E47
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L-FUCULOSE 1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI MUTANT E73Q
Descriptor:L-FUCULOSE 1-PHOSPHATE ALDOLASE, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Joerger, A.C., Schulz, G.E.
Deposit date:2000-06-30
Release date:2000-11-06
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structures of l-fuculose-1-phosphate aldolase mutants outlining motions during catalysis.
J. Mol. Biol., 303, 2000
1E48
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L-FUCULOSE 1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI MUTANT E73Q/Y113F/Y209F
Descriptor:L-FUCULOSE 1-PHOSPHATE ALDOLASE, BETA-MERCAPTOETHANOL, 1,3-DIHYDROXYACETONEPHOSPHATE, ...
Authors:Joerger, A.C., Schulz, G.E.
Deposit date:2000-06-30
Release date:2000-11-06
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.97 Å)
Cite:Structures of L-Fuculose-1-Phosphate Aldolase Mutants Outlining Motions During Catalysis
J.Mol.Biol., 303, 2000
1E49
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L-FUCULOSE 1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI MUTANT N29L/S71A
Descriptor:L-FUCULOSE 1-PHOSPHATE ALDOLASE, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Joerger, A.C., Schulz, G.E.
Deposit date:2000-06-30
Release date:2000-11-06
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.53 Å)
Cite:Structures of L-Fuculose-1-Phosphate Aldolase Mutants Outlining Motions During Catalysis
J.Mol.Biol., 303, 2000
1E4A
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L-FUCULOSE 1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI MUTANT DEL(27)
Descriptor:L-FUCULOSE 1-PHOSPHATE ALDOLASE, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Joerger, A.C., Schulz, G.E.
Deposit date:2000-06-30
Release date:2000-11-06
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Structures of L-Fuculose-1-Phosphate Aldolase Mutants Outlining Motions During Catalysis
J.Mol.Biol., 303, 2000
1E4B
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L-FUCULOSE 1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI MUTANT N29Q
Descriptor:L-FUCULOSE 1-PHOSPHATE ALDOLASE, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Joerger, A.C., Schulz, G.E.
Deposit date:2000-06-30
Release date:2000-11-06
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.84 Å)
Cite:Structures of L-Fuculose-1-Phosphate Aldolase Mutants Outlining Motions During Catalysis
J.Mol.Biol., 303, 2000
1E4C
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L-FUCULOSE 1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI MUTANT S71Q
Descriptor:L-FUCULOSE 1-PHOSPHATE ALDOLASE, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Joerger, A.C., Schulz, G.E.
Deposit date:2000-06-30
Release date:2000-11-06
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structures of L-Fuculose-1-Phosphate Aldolase Mutants Outlining Motions During Catalysis
J.Mol.Biol., 303, 2000
2BIM
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HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-N268D-R273H
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION, SULFATE ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2005-01-25
Release date:2005-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations
J.Biol.Chem., 280, 2005
2BIN
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HUMAN P53 CORE DOMAIN MUTANT M133L-H168R-V203A-N239Y-N268D
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2005-01-25
Release date:2005-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations
J.Biol.Chem., 280, 2005
2BIO
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HUMAN P53 CORE DOMAIN MUTANT M133L-V203A-N239Y-R249S-N268D
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2005-01-25
Release date:2005-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations
J.Biol.Chem., 280, 2005
2BIP
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HUMAN P53 CORE DOMAIN MUTANT M133L-H168R-V203A-N239Y-R249S-N268D
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2005-01-25
Release date:2005-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations
J.Biol.Chem., 280, 2005
2BIQ
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HUMAN P53 CORE DOMAIN MUTANT T123A-M133L-H168R-V203A-N239Y-R249S- N268D
Descriptor:CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2005-01-25
Release date:2005-01-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations
J.Biol.Chem., 280, 2005
1DZU
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L-FUCULOSE-1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI MUTANT T26A
Descriptor:L-FUCULOSE-1-PHOSPHATE ALDOLASE, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Joerger, A.C., Schulz, G.E.
Deposit date:2000-03-07
Release date:2000-06-02
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.09 Å)
Cite:Catalytic Action of Fuculose 1-Phosphate Aldolase (Class II) as Derived from Structure-Directed Mutagenesis
Biochemistry, 39, 2000
1DZV
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L-FUCULOSE-1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI MUTANT Y113F/Y209F
Descriptor:L-FUCULOSE-1-PHOSPHATE ALDOLASE, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Joerger, A.C., Schulz, G.E.
Deposit date:2000-03-07
Release date:2000-06-02
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Catalytic Action of Fuculose 1-Phosphate Aldolase (Class II) as Derived from Structure-Directed Mutagenesis
Biochemistry, 39, 2000
1DZW
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L-FUCULOSE-1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI MUTANT F131A
Descriptor:L-FUCULOSE-1-PHOSPHATE ALDOLASE, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Joerger, A.C., Schulz, G.E.
Deposit date:2000-03-07
Release date:2000-06-02
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.17 Å)
Cite:Catalytic Action of Fuculose 1-Phosphate Aldolase (Class II) as Derived from Structure-Directed Mutagenesis
Biochemistry, 39, 2000
1DZX
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L-FUCULOSE-1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI MUTANT R212A
Descriptor:L-FUCULOSE-1-PHOSPHATE ALDOLASE, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Joerger, A.C., Schulz, G.E.
Deposit date:2000-03-07
Release date:2000-06-02
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.18 Å)
Cite:Catalytic Action of Fuculose 1-Phosphate Aldolase (Class II) as Derived from Structure-Directed Mutagenesis
Biochemistry, 39, 2000
1DZY
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L-FUCULOSE-1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI MUTANT E214A
Descriptor:L-FUCULOSE-1-PHOSPHATE ALDOLASE, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Joerger, A.C., Schulz, G.E.
Deposit date:2000-03-07
Release date:2000-06-02
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (2.44 Å)
Cite:Catalytic Action of Fuculose 1-Phosphate Aldolase (Class II) as Derived from Structure-Directed Mutagenesis
Biochemistry, 39, 2000
1DZZ
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L-FUCULOSE-1-PHOSPHATE ALDOLASE FROM ESCHERICHIA COLI MUTANT Y113F
Descriptor:L-FUCULOSE-1-PHOSPHATE ALDOLASE, SULFATE ION, BETA-MERCAPTOETHANOL, ...
Authors:Joerger, A.C., Schulz, G.E.
Deposit date:2000-03-07
Release date:2000-06-02
Last modified:2019-01-30
Method:X-RAY DIFFRACTION (1.92 Å)
Cite:Catalytic Action of Fuculose 1-Phosphate Aldolase (Class II) as Derived from Structure-Directed Mutagenesis
Biochemistry, 39, 2000
1HL2
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CRYSTAL STRUCTURE OF N-ACETYLNEURAMINATE LYASE FROM E. COLI MUTANT L142R IN COMPLEX WITH B-HYDROXYPYRUVATE
Descriptor:N-ACETYLNEURAMINATE LYASE SUBUNIT, 3-HYDROXYPYRUVIC ACID
Authors:Joerger, A.C., Fersht, A.R.
Deposit date:2003-03-12
Release date:2003-05-09
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Mimicking Natural Evolution in Vitro: An N-Acetylneuraminate Lyase Mutant with an Increased Dihydrodipicolinate Synthase Activity
Proc.Natl.Acad.Sci.USA, 100, 2003