5ABA

Structure of the p53 cancer mutant Y220C with bound small-molecule stabilizer PhiKan5149

Summary for 5ABA

• Entry DOI: 10.2210/pdb5aba/pdb
• Related: 5AB9
• Descriptor: CELLULAR TUMOR ANTIGEN P53, ZINC ION, 1-{1-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl piperidin-4-yl}piperidin-4-ol], ... (4 entities in total)
• Functional Keywords: transcription, cancer, tumor suppression, dna binding, cancer therapy, small molecule stabilizers, molecular chaperone, halogen bonding
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 49999.92

Authors

Joerger, A.C. (deposition date: 2015-08-04, release date: 2015-12-16, Last modification date: 2024-01-10)

• Primary citation: Joerger, A.C.,Bauer, M.R.,Wilcken, R.,Baud, M.G.J.,Harbrecht, H.,Exner, T.E.,Boeckler, F.M.,Spencer, J.,Fersht, A.R.; Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53.; Structure, 23:2246-, 2015; PubMed: 26636255; DOI: 10.1016/J.STR.2015.10.016

Experimental method

X-RAY DIFFRACTION (1.62 Å)