5ABA
Structure of the p53 cancer mutant Y220C with bound small-molecule stabilizer PhiKan5149
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | CELLULAR TUMOR ANTIGEN P53 | polymer | 219 | 24530.8 | 2 | UniProt (P04637) Pfam (PF00870) In PDB | HOMO SAPIENS (HUMAN) | ANTIGEN NY-CO-13, PHOSPHOPROTEIN P53, TUMOR SUPPRESSOR P53, P53 |
2 | A, B | ZINC ION | non-polymer | 65.4 | 2 | Chemie (ZN) | |||
3 | A, B | 1-{1-[(3-bromo-5-chloro-2-hydroxyphenyl)methyl piperidin-4-yl}piperidin-4-ol] | non-polymer | 403.7 | 2 | Chemie (UL7) | |||
4 | water | water | 18.0 | 480 | Chemie (HOH) |
Sequence modifications
A, B: 94 - 312 (UniProt: P04637)
PDB | External Database | Details |
---|---|---|
Leu 133 | Met 133 | engineered mutation |
Ala 203 | Val 203 | engineered mutation |
Cys 220 | Tyr 220 | engineered mutation |
Tyr 239 | Asn 239 | engineered mutation |
Asp 268 | Asn 268 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 49061.6 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 938.3 | |
All* | Total formula weight | 49999.9 |