5AOL

Structure of the p53 cancer mutant Y220C with bound 3-bromo-5-(trifluoromethyl)benzene-1,2-diamine

Summary for 5AOL

• Entry DOI: 10.2210/pdb5aol/pdb
• Related: 5AOI 5AOJ 5AOK 5AOM
• Descriptor: CELLULAR TUMOR ANTIGEN P53, 3-BROMO-5-(TRIFLUOROMETHYL)BENZENE-1,2-DIAMINE, ZINC ION, ... (4 entities in total)
• Functional Keywords: cell cycle, p53, cancer, tumor suppression, dna binding, cancer therapy, small-molecule stabilizers, molecular chaperone
• Biological source: HOMO SAPIENS (HUMAN)
• Total number of polymer chains: 2
• Total formula weight: 49447.48

Authors

Joerger, A.C.,Harbrecht, H. (deposition date: 2015-09-10, release date: 2015-12-16, Last modification date: 2024-01-10)

• Primary citation: Joerger, A.C.,Bauer, M.R.,Wilcken, R.,Baud, M.G.J.,Harbrecht, H.,Exner, T.E.,Boeckler, F.M.,Spencer, J.,Fersht, A.R.; Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53.; Structure, 23:2246-, 2015; PubMed: 26636255; DOI: 10.1016/J.STR.2015.10.016

Experimental method

X-RAY DIFFRACTION (1.5 Å)