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9BPA
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BU of 9bpa by Molmil
Human DNA polymerase theta helicase domain in complex with inhibitor AB25583, tetramer form
Descriptor: (4P)-N-{5-[(4-chlorophenyl)methoxy]-1,3,4-thiadiazol-2-yl}-4-(2-methoxyphenyl)pyridine-3-carboxamide, DNA polymerase theta
Authors:Ito, F, Li, Z, Chen, X.S.
Deposit date:2024-05-07
Release date:2024-08-28
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structural basis for a Pol theta helicase small-molecule inhibitor revealed by cryo-EM.
Nat Commun, 15, 2024
9BP9
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BU of 9bp9 by Molmil
Human DNA polymerase theta helicase domain in complex with inhibitor AB25583, dimer form
Descriptor: (4P)-N-{5-[(4-chlorophenyl)methoxy]-1,3,4-thiadiazol-2-yl}-4-(2-methoxyphenyl)pyridine-3-carboxamide, DNA polymerase theta
Authors:Ito, F, Li, Z, Chen, X.S.
Deposit date:2024-05-07
Release date:2024-08-28
Method:ELECTRON MICROSCOPY (3.21 Å)
Cite:Structural basis for a Pol theta helicase small-molecule inhibitor revealed by cryo-EM.
Nat Commun, 15, 2024
8E40
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BU of 8e40 by Molmil
Full-length APOBEC3G in complex with HIV-1 Vif, CBF-beta, and fork RNA
Descriptor: Core-binding factor subunit beta, DNA dC->dU-editing enzyme APOBEC-3G, RNA, ...
Authors:Ito, F, Alvarez-Cabrera, A.L, Liu, S, Yang, H, Shiriaeva, A, Zhou, Z.H, Chen, X.S.
Deposit date:2022-08-17
Release date:2023-01-11
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (3.57 Å)
Cite:Structural basis for HIV-1 antagonism of host APOBEC3G via Cullin E3 ligase.
Sci Adv, 9, 2023
5W45
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BU of 5w45 by Molmil
Crystal structure of APOBEC3H
Descriptor: APOBEC3H, ZINC ION
Authors:Ito, F, Yang, H.J, Xiao, X, Li, S.X, Wolfe, A, Zirkle, B, Arutiunian, V, Chen, X.S.
Deposit date:2017-06-09
Release date:2018-03-14
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2.486 Å)
Cite:Understanding the Structure, Multimerization, Subcellular Localization and mC Selectivity of a Genomic Mutator and Anti-HIV Factor APOBEC3H.
Sci Rep, 8, 2018
9ASL
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BU of 9asl by Molmil
Human DNA polymerase theta helicase domain tetramer, apo-form
Descriptor: DNA polymerase theta
Authors:Ito, F, Li, Z, Chen, X.S.
Deposit date:2024-02-26
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Biorxiv, 2024
9ASK
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BU of 9ask by Molmil
Human DNA polymerase theta helicase domain dimer, apo-form
Descriptor: DNA polymerase theta
Authors:Ito, F, Li, Z, Chen, X.S.
Deposit date:2024-02-26
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Biorxiv, 2024
9ASJ
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BU of 9asj by Molmil
Human DNA polymerase theta helicase domain in complex with AMP-PNP, dimer form
Descriptor: DNA polymerase theta, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
Authors:Ito, F, Li, Z, Chen, X.S.
Deposit date:2024-02-26
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (3.5 Å)
Cite:Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Biorxiv, 2024
8W0A
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BU of 8w0a by Molmil
Human DNA polymerase theta helicase domain in complex with ssDNA, dimer form
Descriptor: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*T)-3'), DNA polymerase theta
Authors:Ito, F, Li, Z, Chen, X.S.
Deposit date:2024-02-13
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Biorxiv, 2024
9C5Q
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BU of 9c5q by Molmil
Human DNA polymerase theta helicase domain in microhomology annealed state 2, dimer form
Descriptor: DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*CP*CP*CP*GP*GP*G)-3'), DNA polymerase theta
Authors:Ito, F, Li, Z, Chen, X.S.
Deposit date:2024-06-06
Release date:2024-06-26
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Structural Basis for Pol theta-Helicase DNA Binding and Microhomology-Mediated End-Joining.
Biorxiv, 2024
8FVJ
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BU of 8fvj by Molmil
Dimeric form of HIV-1 Vif in complex with human CBF-beta, ELOB, ELOC, and CUL5
Descriptor: Core-binding factor subunit beta, Cullin-5, Elongin-B, ...
Authors:Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S.
Deposit date:2023-01-19
Release date:2023-09-06
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.54 Å)
Cite:Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H.
Nat Commun, 14, 2023
8FVI
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BU of 8fvi by Molmil
Human APOBEC3H bound to HIV-1 Vif in complex with CBF-beta, ELOB, ELOC, and CUL5
Descriptor: Core-binding factor subunit beta, Cullin 5, DNA dC->dU-editing enzyme APOBEC-3H, ...
Authors:Ito, F, Alvarez-Cabrera, A.L, Zhou, Z.H, Chen, X.S.
Deposit date:2023-01-19
Release date:2023-09-06
Last modified:2024-05-01
Method:ELECTRON MICROSCOPY (3.24 Å)
Cite:Structural basis of HIV-1 Vif-mediated E3 ligase targeting of host APOBEC3H.
Nat Commun, 14, 2023
8UD5
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BU of 8ud5 by Molmil
SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, state 2
Descriptor: Non-structural protein 15, RNA (35-MER)
Authors:Ito, F, Yang, H, Zhou, Z.H, Chen, X.S.
Deposit date:2023-09-28
Release date:2024-04-24
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15.
Protein Cell, 15, 2024
8UD4
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BU of 8ud4 by Molmil
SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, state 1
Descriptor: Non-structural protein 15, RNA (35-MER)
Authors:Ito, F, Yang, H, Zhou, Z.H, Chen, X.S.
Deposit date:2023-09-28
Release date:2024-04-24
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15.
Protein Cell, 15, 2024
8UD2
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BU of 8ud2 by Molmil
SARS-CoV-2 Nsp15, apo-form
Descriptor: Non-structural protein 15
Authors:Ito, F, Yang, H, Zhou, Z.H, Chen, X.S.
Deposit date:2023-09-28
Release date:2024-04-24
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (2.33 Å)
Cite:Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15.
Protein Cell, 15, 2024
8UD3
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BU of 8ud3 by Molmil
SARS-CoV-2 Nsp15 bound to poly(A/U) RNA, consensus form
Descriptor: Non-structural protein 15, RNA (35-MER)
Authors:Ito, F, Yang, H, Zhou, Z.H, Chen, X.S.
Deposit date:2023-09-28
Release date:2024-04-24
Last modified:2024-07-10
Method:ELECTRON MICROSCOPY (2.67 Å)
Cite:Structural basis for polyuridine tract recognition by SARS-CoV-2 Nsp15.
Protein Cell, 15, 2024
1Y16
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BU of 1y16 by Molmil
mouse prion protein with mutations S170N and N174T
Descriptor: Major prion protein
Authors:Gossert, A.D, Bonjour, S, Lysek, D.A, Fiorito, F, Wuthrich, K.
Deposit date:2004-11-17
Release date:2005-01-25
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Prion protein NMR structures of elk and of mouse/elk hybrids
Proc.Natl.Acad.Sci.Usa, 102, 2005
1Y15
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BU of 1y15 by Molmil
Mouse Prion Protein with mutation N174T
Descriptor: Major prion protein
Authors:Gossert, A.D, Bonjour, S, Lysek, D.A, Fiorito, F, Wuthrich, K.
Deposit date:2004-11-17
Release date:2004-12-28
Last modified:2021-11-10
Method:SOLUTION NMR
Cite:Prion protein NMR structures of elk and of mouse/elk hybrids
Proc.Natl.Acad.Sci.Usa, 102, 2005
1XYX
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BU of 1xyx by Molmil
mouse prion protein fragment 121-231
Descriptor: Major prion protein
Authors:Gossert, A.D, Bonjour, S, Lysek, D.A, Fiorito, F, Wuthrich, K.
Deposit date:2004-11-11
Release date:2004-11-28
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Prion protein NMR structures of elk and of mouse/elk hybrids
Proc.Natl.Acad.Sci.USA, 102, 2005
1XYJ
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BU of 1xyj by Molmil
NMR Structure of the cat prion protein
Descriptor: prion protein
Authors:Lysek, D.A, Schorn, C, Nivon, L.G, Esteve-Moya, V, Christen, B, Calzolai, L, von Schroetter, C, Fiorito, F, Herrmann, T, Guntert, P.
Deposit date:2004-11-10
Release date:2005-01-04
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Prion protein NMR structures of cats, dogs, pigs, and sheep
Proc.Natl.Acad.Sci.USA, 102, 2005
1XYW
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BU of 1xyw by Molmil
elk prion protein
Descriptor: Major prion protein
Authors:Gossert, A.D, Bonjour, S, Lysek, D.A, Fiorito, F, Wuthrich, K.
Deposit date:2004-11-11
Release date:2004-12-28
Last modified:2022-03-02
Method:SOLUTION NMR
Cite:Prion protein NMR structures of elk and of mouse/elk hybrids
Proc.Natl.Acad.Sci.Usa, 102, 2005
5BPV
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BU of 5bpv by Molmil
Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A
Descriptor: Polymerase cofactor VP35
Authors:Fadda, V, Cannas, V, Zinzula, L, Distinto, S, Daino, G.L, Bianco, G, Corona, A, Esposito, F, Alcaro, S, Maccioni, E, Tramontano, E, Taylor, G.L.
Deposit date:2015-05-28
Release date:2016-06-29
Last modified:2024-01-10
Method:X-RAY DIFFRACTION (1.952 Å)
Cite:Crystal Structure of Zaire ebolavirus VP35 RNA binding domain mutant I278A
to be published
1K91
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BU of 1k91 by Molmil
Solution Structure of Calreticulin P-domain subdomain (residues 221-256)
Descriptor: CALRETICULIN
Authors:Ellgaard, L, Bettendorff, P, Braun, D, Herrmann, T, Fiorito, F, Guntert, P, Helenius, A, Wuthrich, K.
Deposit date:2001-10-26
Release date:2002-10-12
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:NMR Structures of 36 and 73-residue Fragments of the Calreticulin P-domain
J.Mol.Biol., 322, 2002
1K9C
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BU of 1k9c by Molmil
Solution Structure of Calreticulin P-domain subdomain (residues 189-261)
Descriptor: CALRETICULIN
Authors:Ellgaard, L, Bettendorff, P, Braun, D, Herrmann, T, Fiorito, F, Guntert, P, Helenius, A, Wuthrich, K.
Deposit date:2001-10-29
Release date:2002-10-12
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:NMR Structures of 36 and 73-residue Fragments of the Calreticulin P-domain
J.Mol.Biol., 322, 2002
2ZDU
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BU of 2zdu by Molmil
Crystal Structure of human JNK3 complexed with an isoquinolone inhibitor
Descriptor: 4-[(4-{[6-bromo-3-(methoxycarbonyl)-1-oxo-4-phenylisoquinolin-2(1H)-yl]methyl}phenyl)amino]-4-oxobutanoic acid, Mitogen-activated protein kinase 10
Authors:Sogabe, S, Ohra, T, Itoh, F, Habuka, N, Fujishima, A.
Deposit date:2007-11-27
Release date:2008-09-23
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Discovery, synthesis and biological evaluation of isoquinolones as novel and highly selective JNK inhibitors (1)
Bioorg.Med.Chem., 16, 2008
1PN5
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BU of 1pn5 by Molmil
NMR structure of the NALP1 Pyrin domain (PYD)
Descriptor: NACHT-, LRR- and PYD-containing protein 2
Authors:Hiller, S, Kohl, A, Fiorito, F, Herrmann, T, Wider, G, Tschopp, J, Grutter, M.G, Wuthrich, K.
Deposit date:2003-06-12
Release date:2003-10-07
Last modified:2024-05-22
Method:SOLUTION NMR
Cite:NMR structure of the apoptosis- and inflammation-related NALP1 pyrin domain
Structure, 11, 2003

 

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