9BP9

Human DNA polymerase theta helicase domain in complex with inhibitor AB25583, dimer form

Summary for 9BP9

• Entry DOI: 10.2210/pdb9bp9/pdb
• EMDB information: 44765
• Descriptor: DNA polymerase theta, (4P)-N-{5-[(4-chlorophenyl)methoxy]-1,3,4-thiadiazol-2-yl}-4-(2-methoxyphenyl)pyridine-3-carboxamide (2 entities in total)
• Functional Keywords: dna repair, helicase, atpase, transferase-inhibitor complex, transferase/inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 200510.90

Authors

Ito, F.,Li, Z.,Chen, X.S. (deposition date: 2024-05-07, release date: 2024-08-28)

• Primary citation: Ito, F.,Li, Z.,Minakhin, L.,Chandramouly, G.,Tyagi, M.,Betsch, R.,Krais, J.J.,Taberi, B.,Vekariya, U.,Calbert, M.,Skorski, T.,Johnson, N.,Chen, X.S.,Pomerantz, R.T.; Structural basis for a Pol theta helicase small-molecule inhibitor revealed by cryo-EM.; Nat Commun, 15:7003-7003, 2024; PubMed: 39143110; DOI: 10.1038/s41467-024-51351-4

Experimental method

ELECTRON MICROSCOPY (3.21 Å)