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1CCS
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STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
Descriptor:CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1994-12-09
Release date:1995-02-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.
Proc.Natl.Acad.Sci.USA, 92, 1995
1CCT
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STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
Descriptor:CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1994-12-09
Release date:1995-02-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.
Proc.Natl.Acad.Sci.USA, 92, 1995
1CCU
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STRUCTURE-ASSISTED REDESIGN OF A PROTEIN-ZINC BINDING SITE WITH FEMTOMOLAR AFFINITY
Descriptor:CARBONIC ANHYDRASE II, ZINC ION, SULFATE ION
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1994-12-09
Release date:1995-02-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structure-assisted redesign of a protein-zinc-binding site with femtomolar affinity.
Proc.Natl.Acad.Sci.USA, 92, 1995
1CNB
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COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES
Descriptor:CARBONIC ANHYDRASE II, BETA-MERCAPTOETHANOL
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1994-06-13
Release date:1994-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Structural consequences of redesigning a protein-zinc binding site.
Biochemistry, 33, 1994
1CNC
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COMPENSATORY PLASTIC EFFECTS IN THE REDESIGN OF PROTEIN-ZINC BINDING SITES
Descriptor:CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1994-06-13
Release date:1994-10-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural consequences of redesigning a protein-zinc binding site.
Biochemistry, 33, 1994
1CSL
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CRYSTAL STRUCTURE OF THE RRE HIGH AFFINITY SITE
Descriptor:5'-R(*AP*AP*CP*GP*GP*GP*CP*GP*CP*AP*GP*AP*A)-3', 5'-R(*UP*CP*UP*GP*AP*CP*GP*GP*UP*AP*CP*GP*UP*UP*U)-3'
Authors:Ippolito, J.A., Steitz, T.A.
Deposit date:1999-08-18
Release date:2000-02-14
Last modified:2011-12-28
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The structure of the HIV-1 RRE high affinity rev binding site at 1.6 A resolution.
J.Mol.Biol., 295, 2000
1CVD
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STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
Descriptor:CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1994-06-21
Release date:1994-12-20
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structural consequences of redesigning a protein-zinc binding site.
Biochemistry, 33, 1994
1CVE
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STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
Descriptor:CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1994-06-21
Release date:1994-11-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural consequences of redesigning a protein-zinc binding site.
Biochemistry, 33, 1994
1CVF
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STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
Descriptor:CARBONIC ANHYDRASE II
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1994-06-21
Release date:1994-11-30
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural consequences of redesigning a protein-zinc binding site.
Biochemistry, 33, 1994
1CVH
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STRUCTURAL CONSEQUENCES OF REDESIGNING A PROTEIN-ZINC BINDING SITE
Descriptor:CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1994-11-16
Release date:1995-02-07
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structural consequences of redesigning a protein-zinc binding site.
Biochemistry, 33, 1994
1DCA
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STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH
Descriptor:CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1992-12-18
Release date:1993-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Structure of an engineered His3Cys zinc binding site in human carbonic anhydrase II.
Biochemistry, 32, 1993
1DCB
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STRUCTURE OF AN ENGINEERED METAL BINDING SITE IN HUMAN CARBONIC ANHYDRASE II REVEALS THE ARCHITECTURE OF A REGULATORY CYSTEINE SWITCH
Descriptor:CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1993-03-10
Release date:1993-07-15
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structure of an engineered His3Cys zinc binding site in human carbonic anhydrase II.
Biochemistry, 32, 1993
397D
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A 1.3 A RESOLUTION CRYSTAL STRUCTURE OF THE HIV-1 TRANS-ACTIVATION RESPONSE REGION RNA STEM REVEALS A METAL ION-DEPENDENT BULGE CONFORMATION
Descriptor:RNA (5'-R(*GP*GP*CP*CP*AP*GP*AP*UP*CP*UP*GP*AP*GP*CP*G)-3'), RNA (5'-R(*GP*CP*UP*CP*UP*CP*UP*GP*GP*CP*CP*C)-3'), CALCIUM ION
Authors:Ippolito, J.A., Steitz, T.A.
Deposit date:1998-04-30
Release date:1998-09-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:A 1.3-A resolution crystal structure of the HIV-1 trans-activation response region RNA stem reveals a metal ion-dependent bulge conformation.
Proc.Natl.Acad.Sci.USA, 95, 1998
3CPW
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THE STRUCTURE OF THE ANTIBIOTIC LINEZOLID BOUND TO THE LARGE RIBOSOMAL SUBUNIT OF HALOARCULA MARISMORTUI
Descriptor:23S RIBOSOMAL RNA, 5S RIBOSOMAL RNA, 50S ribosomal protein L2P, ...
Authors:Ippolito, J.A., Kanyo, Z.K., Wang, D., Franceschi, F.J., Moore, P.B., Steitz, T.A., Duffy, E.M.
Deposit date:2008-04-01
Release date:2008-07-22
Last modified:2018-04-25
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Crystal Structure of the Oxazolidinone Antibiotic Linezolid Bound to the 50S Ribosomal Subunit
J.Med.Chem., 51, 2008
1CVA
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STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II
Descriptor:CARBONIC ANHYDRASE II, ZINC ION, AZIDE ION
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1993-02-04
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II.
J.Biol.Chem., 268, 1993
1CVB
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STRUCTURAL AND FUNCTIONAL IMPORTANCE OF A CONSERVED HYDROGEN BOND NETWORK IN HUMAN CARBONIC ANHYDRASE II
Descriptor:CARBONIC ANHYDRASE II, ZINC ION, SULFATE ION
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1993-02-04
Release date:1993-10-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Structural and functional importance of a conserved hydrogen bond network in human carbonic anhydrase II.
J.Biol.Chem., 268, 1993
1CVC
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REDESIGNING THE ZINC BINDING SITE OF HUMAN CARBONIC ANHYDRASE II: STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON
Descriptor:CARBONIC ANHYDRASE II, ZINC ION
Authors:Ippolito, J.A., Christianson, D.W.
Deposit date:1993-09-22
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:REDESIGNING THE ZINC-BINDING SITE OF HUMAN CARBONIC ANHYDRASE-II - STRUCTURE OF A HIS2ASP-ZN2+ METAL COORDINATION POLYHEDRON.
J.Am.Chem.Soc., 115, 1993
3CXC
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THE STRUCTURE OF AN ENHANCED OXAZOLIDINONE INHIBITOR BOUND TO THE 50S RIBOSOMAL SUBUNIT OF H. MARISMORTUI
Descriptor:23S RIBOSOMAL RNA, 5S RIBOSOMAL RNA, 5'-R(*CP*CP*A)-3', ...
Authors:Ippolito, J.A., Wang, D., Kanyo, Z.F., Duffy, E.M.
Deposit date:2008-04-24
Release date:2009-04-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics.
Bioorg.Med.Chem.Lett., 18, 2008
1K8A
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CO-CRYSTAL STRUCTURE OF CARBOMYCIN A BOUND TO THE 50S RIBOSOMAL SUBUNIT OF HALOARCULA MARISMORTUI
Descriptor:23S RRNA, 5S RRNA, RIBOSOMAL PROTEIN L2, ...
Authors:Hansen, J.L., Ippolito, J.A., Ban, N., Nissen, P., Moore, P.B., Steitz, T.
Deposit date:2001-10-23
Release date:2002-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structures of four macrolide antibiotics bound to the large ribosomal subunit.
Mol.Cell, 10, 2002
1K9M
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CO-CRYSTAL STRUCTURE OF TYLOSIN BOUND TO THE 50S RIBOSOMAL SUBUNIT OF HALOARCULA MARISMORTUI
Descriptor:23S RRNA, 5S RRNA, RIBOSOMAL PROTEIN L2, ...
Authors:Hansen, J.L., Ippolito, J.A., Ban, N., Nissen, P., Moore, P.B., Steitz, T.A.
Deposit date:2001-10-29
Release date:2002-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structures of four macrolide antibiotics bound to the large ribosomal subunit.
Mol.Cell, 10, 2002
1KD1
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CO-CRYSTAL STRUCTURE OF SPIRAMYCIN BOUND TO THE 50S RIBOSOMAL SUBUNIT OF HALOARCULA MARISMORTUI
Descriptor:23S RRNA, 5S RRNA, RIBOSOMAL PROTEIN L2, ...
Authors:Hansen, J.L., Ippolito, J.A., Ban, N., Nissen, P., Moore, P.B., Steitz, T.A.
Deposit date:2001-11-12
Release date:2002-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:The structures of four macrolide antibiotics bound to the large ribosomal subunit.
Mol.Cell, 10, 2002
1M1K
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CO-CRYSTAL STRUCTURE OF AZITHROMYCIN BOUND TO THE 50S RIBOSOMAL SUBUNIT OF HALOARCULA MARISMORTUI
Descriptor:23S RRNA, 5S RRNA, RIBOSOMAL PROTEIN L2, ...
Authors:Hansen, J.L., Ippolito, J.A., Ban, N., Nissen, P., Moore, P.B., Steitz, T.A.
Deposit date:2002-06-19
Release date:2002-07-19
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:The structures of four macrolide antibiotics bound to the large ribosomal subunit.
Mol.Cell, 10, 2002