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3CXC

The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui

Summary for 3CXC
Entry DOI10.2210/pdb3cxc/pdb
Descriptor23S RIBOSOMAL RNA, RIBOSOMAL PROTEIN L10, RIBOSOMAL PROTEIN L10E, ... (38 entities in total)
Functional Keywords50s ribosomal subunit, oxazolidinone, ribosome
Biological sourceHaloarcula marismortui
More
Total number of polymer chains31
Total formula weight1459563.32
Authors
Ippolito, J.A.,Wang, D.,Kanyo, Z.F.,Duffy, E.M. (deposition date: 2008-04-24, release date: 2009-04-28, Last modification date: 2023-08-30)
Primary citationZhou, J.,Bhattacharjee, A.,Chen, S.,Chen, Y.,Duffy, E.,Farmer, J.,Goldberg, J.,Hanselmann, R.,Ippolito, J.A.,Lou, R.,Orbin, A.,Oyelere, A.,Salvino, J.,Springer, D.,Tran, J.,Wang, D.,Wu, Y.,Johnson, G.
Design at the atomic level: design of biaryloxazolidinones as potent orally active antibiotics.
Bioorg.Med.Chem.Lett., 18:6175-6178, 2008
Cited by
PubMed Abstract: We have developed a first generation of hybrid sparsomycin-linezolid compounds into a new family of orally bioavailable biaryloxazolidinones that have activity against both linezolid-susceptible and -resistant gram-positive bacteria as well as the fastidious gram-negative bacteria Haemophilus influenzae and Moraxella catarrahalis. The convergent synthesis of these new compounds is detailed.
PubMed: 18947996
DOI: 10.1016/j.bmcl.2008.10.011
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3 Å)
Structure validation

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