3CXC
The structure of an enhanced oxazolidinone inhibitor bound to the 50S ribosomal subunit of H. marismortui
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (0) | 23S RIBOSOMAL RNA | polymer | 2922 | 946034.4 | 1 | GenBank (3377779) | Haloarcula marismortui | |
| 2 | B (9) | 5S RIBOSOMAL RNA | polymer | 122 | 39318.4 | 1 | GenBank (3377779) | Haloarcula marismortui | |
| 3 | C (4) | 5'-R(*CP*CP*A)-3' | polymer | 3 | 894.6 | 1 | |||
| 4 | D (A) | RIBOSOMAL PROTEIN L2 | polymer | 239 | 25237.5 | 1 | UniProt (P20276) Pfam (PF00181) Pfam (PF03947) | Haloarcula marismortui | |
| 5 | E (B) | RIBOSOMAL PROTEIN L3 | polymer | 337 | 37265.2 | 1 | UniProt (P20279) Pfam (PF00297) | Haloarcula marismortui | |
| 6 | F (C) | RIBOSOMAL PROTEIN L4 | polymer | 246 | 26442.1 | 1 | UniProt (P12735) Pfam (PF00573) | Haloarcula marismortui | |
| 7 | G (D) | RIBOSOMAL PROTEIN L5 | polymer | 176 | 19420.5 | 1 | UniProt (P14124) Pfam (PF00281) Pfam (PF00673) | Haloarcula marismortui | |
| 8 | H (E) | RIBOSOMAL PROTEIN L6 | polymer | 177 | 19830.5 | 1 | UniProt (P14135) Pfam (PF00347) | Haloarcula marismortui | |
| 9 | I (F) | RIBOSOMAL PROTEIN L7AE | polymer | 119 | 12600.8 | 1 | UniProt (P12743) Pfam (PF01248) | Haloarcula marismortui | |
| 10 | J (G) | RIBOSOMAL PROTEIN L10 | polymer | 348 | 37213.8 | 1 | UniProt (P15825) Pfam (PF00466) Pfam (PF17777) | Haloarcula marismortui | |
| 11 | K (H) | RIBOSOMAL PROTEIN L10E | polymer | 167 | 18022.5 | 1 | PDB (1JJ2) | Haloarcula marismortui | |
| 12 | L (I) | RIBOSOMAL PROTEIN L13 | polymer | 145 | 16249.2 | 1 | UniProt (P29198) Pfam (PF00572) | Haloarcula marismortui | |
| 13 | M (J) | RIBOSOMAL PROTEIN L14 | polymer | 132 | 14216.2 | 1 | UniProt (P22450) Pfam (PF00238) | Haloarcula marismortui | |
| 14 | N (K) | RIBOSOMAL PROTEIN L15 | polymer | 164 | 17874.2 | 1 | UniProt (P12737) Pfam (PF00828) | Haloarcula marismortui | |
| 15 | O (L) | RIBOSOMAL PROTEIN L15E | polymer | 194 | 22856.6 | 1 | PDB (1JJ2) | Haloarcula marismortui | |
| 16 | P (M) | RIBOSOMAL PROTEIN L18 | polymer | 186 | 20509.7 | 1 | UniProt (P14123) Pfam (PF17144) | Haloarcula marismortui | |
| 17 | Q (N) | RIBOSOMAL PROTEIN L18E | polymer | 115 | 12307.7 | 1 | UniProt (P12733) Pfam (PF00828) | Haloarcula marismortui | |
| 18 | R (O) | RIBOSOMAL PROTEIN L19E | polymer | 148 | 16631.3 | 1 | UniProt (P14119) Pfam (PF01280) | Haloarcula marismortui | |
| 19 | S (P) | RIBOSOMAL PROTEIN L21E | polymer | 95 | 10436.6 | 1 | UniProt (P12734) Pfam (PF01157) | Haloarcula marismortui | |
| 20 | T (Q) | RIBOSOMAL PROTEIN L22 | polymer | 154 | 16835.7 | 1 | UniProt (P10970) Pfam (PF00237) | Haloarcula marismortui | |
| 21 | U (R) | RIBOSOMAL PROTEIN L23 | polymer | 84 | 9481.3 | 1 | UniProt (P12732) Pfam (PF00276) | Haloarcula marismortui | |
| 22 | V (S) | RIBOSOMAL PROTEIN L24 | polymer | 119 | 13539.8 | 1 | UniProt (P10972) Pfam (PF16906) Pfam (PF00467) | Haloarcula marismortui | |
| 23 | W (T) | RIBOSOMAL PROTEIN L24E | polymer | 66 | 7233.7 | 1 | UniProt (P14116) Pfam (PF01246) | Haloarcula marismortui | |
| 24 | X (U) | RIBOSOMAL PROTEIN L29 | polymer | 70 | 7758.7 | 1 | UniProt (P10971) Pfam (PF00831) | Haloarcula marismortui | |
| 25 | Y (V) | RIBOSOMAL PROTEIN L30 | polymer | 154 | 17062.9 | 1 | UniProt (P14121) Pfam (PF00327) | Haloarcula marismortui | |
| 26 | Z (W) | RIBOSOMAL PROTEIN L31E | polymer | 91 | 10253.4 | 1 | UniProt (P18138) Pfam (PF01198) | Haloarcula marismortui | |
| 27 | AA (X) | RIBOSOMAL PROTEIN L32E | polymer | 240 | 26324.5 | 1 | UniProt (P12736) Pfam (PF14520) Pfam (PF01655) | Haloarcula marismortui | |
| 28 | BA (Y) | RIBOSOMAL PROTEIN L37AE | polymer | 73 | 8097.8 | 1 | PDB (1JJ2) | Haloarcula marismortui | |
| 29 | CA (Z) | RIBOSOMAL PROTEIN L37E | polymer | 56 | 6199.0 | 1 | UniProt (P32410) Pfam (PF01907) | Haloarcula marismortui | |
| 30 | DA (1) | RIBOSOMAL PROTEIN L39E | polymer | 48 | 5844.7 | 1 | UniProt (P22452) Pfam (PF00832) | Haloarcula marismortui | |
| 31 | EA (2) | RIBOSOMAL PROTEIN L44E | polymer | 92 | 10815.2 | 1 | UniProt (P32411) Pfam (PF00935) | Haloarcula marismortui | |
| 32 | FA (0) | (3Z)-N-[(4E)-5-(4-{(5S)-5-[(acetylamino)methyl]-2-oxo-1,3-oxazolidin-3-yl}-2-fluorophenyl)pent-4-en-1-yl]-3-(4-methyl-2,6-dioxo-1,6-dihydropyrimidin-5(2H)-ylidene)propanamide | non-polymer | 513.5 | 1 | Chemie (SLD) | |||
| 33 | AB, AC, AD, AE, BB... (0, 2, J, 9, 4...) | MAGNESIUM ION | non-polymer | 24.3 | 117 | Chemie (MG) | |||
| 34 | JE, KE (0) | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
| 35 | AF, AG, AH, AI, BF... (0, H, I, K, L...) | SODIUM ION | non-polymer | 23.0 | 86 | Chemie (NA) | |||
| 36 | DI, DJ, EI, FI, GH... (I, 2, 0, J, K...) | CHLORIDE ION | non-polymer | 35.5 | 22 | Chemie (CL) | |||
| 37 | AJ, CJ, NI, WI, ZI (Z, 2, N, T, Y) | CADMIUM ION | non-polymer | 112.4 | 5 | Chemie (CD) | |||
| 38 | AK, BK, CK, DK, EJ... (T, U, V, W, 0...) | water | water | 18.0 | 7870 | Chemie (HOH) |
Sequence modifications
0: 2 - 2923 (GenBank: 3377779)
B: 1 - 337 (UniProt: P20279)
O: 1 - 148 (UniProt: P14119)
1: 1 - 49 (UniProt: P22452)
| PDB | External Database | Details |
|---|---|---|
| C 560 | U 3155 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Arg 310 | Pro 311 | conflict |
| PDB | External Database | Details |
|---|---|---|
| Lys 71 | Tyr 71 | conflict |
| PDB | External Database | Details |
|---|---|---|
| - | Arg 31 | deletion |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 31 |
| Total formula weight | 1452808.8 | |
| Non-Polymers* | Number of molecules | 233 |
| Total formula weight | 6754.6 | |
| All* | Total formula weight | 1459563.3 |
