7T0P
JAK2 JH2 IN COMPLEX WITH JAK315
Summary for 7T0P
Entry DOI | 10.2210/pdb7t0p/pdb |
Descriptor | Tyrosine-protein kinase JAK2, 4'-{[5-amino-3-(4-sulfamoylanilino)-1H-1,2,4-triazole-1-carbonyl]amino}-4-(benzyloxy)[1,1'-biphenyl]-3-carboxylic acid, GLYCEROL, ... (4 entities in total) |
Functional Keywords | pseudokinase domain, inhibitor, complex, transferase, transferase-transferase inhibitor complex, signaling protein, transferase-inhibitor complex, transferase/inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 67625.34 |
Authors | Ippolito, J.A.,Liosi, M.-E.,Krimmer, S.G.,Schlessinger, J.,Jorgensen, W.L. (deposition date: 2021-11-30, release date: 2022-06-15, Last modification date: 2023-10-18) |
Primary citation | Liosi, M.E.,Ippolito, J.A.,Henry, S.P.,Krimmer, S.G.,Newton, A.S.,Cutrona, K.J.,Olivarez, R.A.,Mohanty, J.,Schlessinger, J.,Jorgensen, W.L. Insights on JAK2 Modulation by Potent, Selective, and Cell-Permeable Pseudokinase-Domain Ligands. J.Med.Chem., 65:8380-8400, 2022 Cited by PubMed: 35653642DOI: 10.1021/acs.jmedchem.2c00283 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.04 Å) |
Structure validation
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