7T0P
JAK2 JH2 IN COMPLEX WITH JAK315
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Tyrosine-protein kinase JAK2 | polymer | 289 | 33121.0 | 2 | UniProt (O60674) Pfam (PF07714) In PDB | Homo sapiens (human) | Janus kinase 2,JAK-2 |
2 | A, B | 4'-{[5-amino-3-(4-sulfamoylanilino)-1H-1,2,4-triazole-1-carbonyl]amino}-4-(benzyloxy)[1,1'-biphenyl]-3-carboxylic acid | non-polymer | 599.6 | 2 | Chemie (E3W) | |||
3 | A, B | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
4 | water | water | 18.0 | 311 | Chemie (HOH) |
Sequence modifications
A, B: 536 - 812 (UniProt: O60674)
PDB | External Database | Details |
---|---|---|
Ala 659 | Trp 659 | engineered mutation |
Ala 777 | Trp 777 | engineered mutation |
His 794 | Phe 794 | engineered mutation |
Leu 813 | - | expression tag |
Val 814 | - | expression tag |
Pro 815 | - | expression tag |
Arg 816 | - | expression tag |
Gly 817 | - | expression tag |
Ser 818 | - | expression tag |
His 819 | - | expression tag |
His 820 | - | expression tag |
His 821 | - | expression tag |
His 822 | - | expression tag |
His 823 | - | expression tag |
His 824 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 66241.9 | |
Non-Polymers* | Number of molecules | 4 |
Total formula weight | 1383.4 | |
All* | Total formula weight | 67625.3 |