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2KUN
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BU of 2kun by Molmil
Three dimensional structure of HuPrP(90-231 M129 Q212P)
Descriptor: Major prion protein
Authors:Ilc, G, Giachin, G, Jaremko, M, Jaremko, L, Zhukov, I, Plavec, J, Legname, G, Benetti, F.
Deposit date:2010-02-23
Release date:2010-08-25
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:NMR structure of the human prion protein with the pathological Q212P mutation reveals unique structural features.
Plos One, 5, 2010
2MVK
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BU of 2mvk by Molmil
Solution structure of phosphorylated cytosolic part of Trop2
Descriptor: Tumor-associated calcium signal transducer 2
Authors:Ilc, G, Plavec, J, Vidmar, T, Pavsic, M, Lenarcic, B.
Deposit date:2014-10-08
Release date:2015-05-06
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:The cytosolic tail of the tumor marker protein Trop2--a structural switch triggered by phosphorylation.
Sci Rep, 5, 2015
2MVL
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BU of 2mvl by Molmil
Solution structure of cytosolic part of Trop2
Descriptor: Tumor-associated calcium signal transducer 2
Authors:Ilc, G, Plavec, J, Vidmar, T, Pavsic, M, Lenarcic, B.
Deposit date:2014-10-08
Release date:2015-05-06
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:The cytosolic tail of the tumor marker protein Trop2--a structural switch triggered by phosphorylation.
Sci Rep, 5, 2015
5LKN
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BU of 5lkn by Molmil
NMR solution structure of human FNIII domain 2 of NCAM
Descriptor: Neural cell adhesion molecule 1
Authors:Slapsak, U, Salzano, G, Amin, L, Abskharon, R.N.N, Ilc, G, Zupancic, B, Biljan, I, Plavec, J, Giachin, G, Legname, G.
Deposit date:2016-07-22
Release date:2016-09-14
Last modified:2024-06-19
Method:SOLUTION NMR
Cite:The N Terminus of the Prion Protein Mediates Functional Interactions with the Neuronal Cell Adhesion Molecule (NCAM) Fibronectin Domain.
J.Biol.Chem., 291, 2016
2LEJ
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BU of 2lej by Molmil
human prion protein mutant HuPrP(90-231, M129, V210I)
Descriptor: Major prion protein
Authors:Biljan, I, Ilc, G, Giachin, G, Raspadori, A, Zhukov, I, Plavec, J, Legname, G.
Deposit date:2011-06-16
Release date:2011-08-17
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Toward the Molecular Basis of Inherited Prion Diseases: NMR Structure of the Human Prion Protein with V210I Mutation.
J.Mol.Biol., 412, 2011
6FNV
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BU of 6fnv by Molmil
Solution structure of mule deer prion protein with polymorphism S138
Descriptor: Major prion protein
Authors:Slapsak, U, Ilc, G, Plavec, J.
Deposit date:2018-02-05
Release date:2019-08-28
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Solution structure of mule deer prion protein with polymorphism S138
To Be Published
2LFT
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BU of 2lft by Molmil
Human prion protein with E219K protective polymorphism
Descriptor: Major prion protein
Authors:Biljan, I, Ilc, G, Giacin, G, Zhukov, I, Plavec, J, Legname, G.
Deposit date:2011-07-14
Release date:2012-06-27
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis for the protective effect of the human prion protein carrying the dominant-negative E219K polymorphism.
Biochem.J., 446, 2012
2LSB
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BU of 2lsb by Molmil
Solution-state NMR structure of the human prion protein
Descriptor: Major prion protein
Authors:Biljan, I, Ilc, G, Giancin, G, Zhukov, I, Plavec, J, Legname, G.
Deposit date:2012-04-26
Release date:2012-06-27
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural basis for the protective effect of the human prion protein carrying the dominant-negative E219K polymorphism.
Biochem.J., 446, 2012
2LV1
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BU of 2lv1 by Molmil
Solution-state NMR structure of prion protein mutant V210I at neutral pH
Descriptor: Major prion protein
Authors:Biljan, I, Ilc, G, Giachin, G, Legname, G, Plavec, J.
Deposit date:2012-06-26
Release date:2012-09-19
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Structural Rearrangements at Physiological pH: Nuclear Magnetic Resonance Insights from the V210I Human Prion Protein Mutant.
Biochemistry, 51, 2012
5L6R
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BU of 5l6r by Molmil
PrP226* - Solution-state NMR structure of truncated human prion protein
Descriptor: Major prion protein
Authors:Kovac, V, Zupancic, B, Ilc, G, Curin Serbec, V, Plavec, J.
Deposit date:2016-05-31
Release date:2016-10-05
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Truncated prion protein PrP226* - A structural view on its role in amyloid disease.
Biochem. Biophys. Res. Commun., 484, 2017
2MAE
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BU of 2mae by Molmil
Transmembrane-cytosolic part of Trop2 explored by NMR and Molecular Dynamics
Descriptor: Tumor-associated calcium signal transducer 2
Authors:Vidmar, T, Pavi, M, Ilc, G, Plavec, J, Lenari, B.
Deposit date:2013-07-08
Release date:2014-07-09
Last modified:2023-06-14
Method:SOLUTION NMR
Cite:Transmembrane-cytosolic part of Trop2 explored by NMR and Molecular Dynamics
To be Published
2N8Z
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BU of 2n8z by Molmil
Apo form of Calmodulin-Like Domain of Human Non-Muscle alpha-actinin 1
Descriptor: Alpha-actinin-1
Authors:Drmota Prebil, S, Slapsak, U, de Almeida Ribeiro, E, Pavsic, M, Ilc, G, Zielinska, K, Hartl, M, Backman, L, Plavec, J, Lenarcic, B, Djinovic-Carugo, K.
Deposit date:2015-10-28
Release date:2016-06-29
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structure and calcium-binding studies of calmodulin-like domain of human non-muscle alpha-actinin-1.
Sci Rep, 6, 2016
2N8Y
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BU of 2n8y by Molmil
Holo form of Calmodulin-Like Domain of Human Non-Muscle alpha-actinin 1
Descriptor: Alpha-actinin-1, CALCIUM ION
Authors:Drmota Prebil, S, Slapsak, U, de Almeida Ribeiro, E, Pavsic, M, Ilc, G, Zielinska, K, Hartl, M, Backman, L, Plavec, J, Lenarcic, B, Djinovic-Carugo, K.
Deposit date:2015-10-28
Release date:2016-06-29
Last modified:2024-05-15
Method:SOLUTION NMR
Cite:Structure and calcium-binding studies of calmodulin-like domain of human non-muscle alpha-actinin-1.
Sci Rep, 6, 2016
1XS7
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BU of 1xs7 by Molmil
Crystal Structure of a cycloamide-urethane-derived novel inhibitor bound to human brain memapsin 2 (beta-secretase).
Descriptor: Beta-secretase 1, N-[(4S,5S,7R)-8-({(S)-1-[(BENZYLAMINO)OXOMETHYL]-2-METHYLPROPYL}AMINO)-5-HYDROXY-2,7-DIMETHYL-8-OXO-OCT-4-YL]-(4S,7S)-4 -ISOPROPYL-2,5,9-TRIOXO-1-OXA-3,6,10-TRIAZACYCLOHEXADECANE-7-CARBOXAMIDE
Authors:Ghosh, A, Devasamudram, T, Hong, L, DeZutter, C, Xu, X, Weerasena, V, Koelsch, G, Bilcer, G, Tang, J.
Deposit date:2004-10-18
Release date:2004-12-21
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure-based design of cycloamide-urethane-derived novel inhibitors of human brain memapsin 2 (beta-secretase).
Bioorg.Med.Chem.Lett., 15, 2005
1HE7
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BU of 1he7 by Molmil
Human Nerve growth factor receptor TrkA
Descriptor: GLYCEROL, HIGH AFFINITY NERVE GROWTH FACTOR RECEPTOR
Authors:Banfield, M, Robertson, A, Allen, S, Dando, J, Tyler, S, Bennett, G, Brain, S, Mason, G, Holden, P, Clarke, A, Naylor, R, Wilcock, G, Brady, R, Dawbarn, D.
Deposit date:2000-11-20
Release date:2001-04-02
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Identification and Structure of the Nerve Growth Factor Binding Site on Trka.
Biochem.Biophys.Res.Commun., 282, 2001
2G94
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BU of 2g94 by Molmil
Crystal structure of beta-secretase bound to a potent and highly selective inhibitor.
Descriptor: Beta-secretase 1, N~2~-[(2R,4S,5S)-5-{[N-{[(3,5-DIMETHYL-1H-PYRAZOL-1-YL)METHOXY]CARBONYL}-3-(METHYLSULFONYL)-L-ALANYL]AMINO}-4-HYDROXY-2,7-DIMETHYLOCTANOYL]-N-ISOBUTYL-L-VALINAMIDE
Authors:Hong, L, Ghosh, A, Tang, J.
Deposit date:2006-03-05
Release date:2006-04-25
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Design, synthesis and X-ray structure of protein-ligand complexes: important insight into selectivity of memapsin 2 (beta-secretase) inhibitors.
J.Am.Chem.Soc., 128, 2006
2P4J
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BU of 2p4j by Molmil
Crystal structure of beta-secretase bond to an inhibitor with Isophthalamide Derivatives at P2-P3
Descriptor: Beta-secretase 1, N-[(1S,2S,4R)-2-HYDROXY-1-ISOBUTYL-5-({(1S)-1-[(ISOPROPYLAMINO)CARBONYL]-2-METHYLPROPYL}AMINO)-4-METHYL-5-OXOPENTYL]-5-[METHYL(METHYLSULFONYL)AMINO]-N'-[(1R)-1-PHENYLETHYL]ISOPHTHALAMIDE
Authors:Hong, L, Ghosh, A.K, Tang, J.
Deposit date:2007-03-12
Release date:2007-07-24
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Design, synthesis, and X-ray structure of potent memapsin 2 (beta-secretase) inhibitors with isophthalamide derivatives as the P2-P3-ligands.
J.Med.Chem., 50, 2007
6N3W
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BU of 6n3w by Molmil
Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound 5'-O-[3-Phenyl-1-Ethyl]Carbamoyl Guanosine
Descriptor: 5'-O-[(2-phenylethyl)carbamoyl]guanosine, Histidine triad nucleotide-binding protein 1
Authors:Strom, A.M, Finzel, B.C.
Deposit date:2018-11-16
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice.
Acs Chem Neurosci, 10, 2019
6N3Y
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BU of 6n3y by Molmil
Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound 5'-O-[(3-Indolyl)-1-Ethyl]Carbamoyl Guanosine
Descriptor: 5'-O-{[2-(1H-indol-3-yl)ethyl]carbamoyl}guanosine, CHLORIDE ION, Histidine triad nucleotide-binding protein 1
Authors:Strom, A.M, Finzel, B.C.
Deposit date:2018-11-16
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice.
Acs Chem Neurosci, 10, 2019
6N3V
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BU of 6n3v by Molmil
Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound 5'-O-[1-Ethyl]Carbamoyl Guanosine
Descriptor: 5'-O-(ethylcarbamoyl)guanosine, CHLORIDE ION, Histidine triad nucleotide-binding protein 1
Authors:Strom, A.M, Finzel, B.C.
Deposit date:2018-11-16
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice.
Acs Chem Neurosci, 10, 2019
6N3X
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BU of 6n3x by Molmil
Human Histidine Triad Nucleotide Binding Protein 1 (Hint1) with Bound 5'-O-[1-Benzyl]Carbamoyl Guanosine
Descriptor: 1,2-ETHANEDIOL, 5'-O-(benzylcarbamoyl)guanosine, CHLORIDE ION, ...
Authors:Strom, A.M, Finzel, B.C.
Deposit date:2018-11-16
Release date:2019-09-18
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Inhibition of HINT1 Modulates Spinal Nociception and NMDA Evoked Behavior in Mice.
Acs Chem Neurosci, 10, 2019
2IEN
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BU of 2ien by Molmil
Crystal structure analysis of HIV-1 protease with a potent non-peptide inhibitor (UIC-94017)
Descriptor: (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE, ACETIC ACID, CHLORIDE ION, ...
Authors:Tie, Y, Boross, P.I, Wang, Y.F, Gaddis, L, Manna, D, Hussain, A.K, Leshchenko, S, Ghosh, A.K, Louis, J.M, Harrison, R.W, Weber, I.T.
Deposit date:2006-09-19
Release date:2006-10-03
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:High Resolution Crystal Structures of HIV-1 Protease with a Potent Non-Peptide Inhibitor (Uic-94017) Active Against Multi-Drug-Resistant Clinical Strains.
J.Mol.Biol., 338, 2004

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