2LFT
Human prion protein with E219K protective polymorphism
Summary for 2LFT
| Entry DOI | 10.2210/pdb2lft/pdb |
| Related | 1QM1 |
| NMR Information | BMRB: 17780 |
| Descriptor | Major prion protein (1 entity in total) |
| Functional Keywords | protective mutant, membrane protein, protein fibril |
| Biological source | Homo sapiens (human) |
| Cellular location | Cell membrane; Lipid-anchor, GPI-anchor. Isoform 2: Cytoplasm: P04156 |
| Total number of polymer chains | 1 |
| Total formula weight | 16169.06 |
| Authors | Biljan, I.,Ilc, G.,Giacin, G.,Zhukov, I.,Plavec, J.,Legname, G. (deposition date: 2011-07-14, release date: 2012-06-27, Last modification date: 2023-06-14) |
| Primary citation | Biljan, I.,Giachin, G.,Ilc, G.,Zhukov, I.,Plavec, J.,Legname, G. Structural basis for the protective effect of the human prion protein carrying the dominant-negative E219K polymorphism. Biochem.J., 446:243-251, 2012 Cited by PubMed: 22676969DOI: 10.1042/BJ20111940 PDB entries with the same primary citation |
| Experimental method | SOLUTION NMR |
Structure validation
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