Author results

4HN5
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GR DNA BINDING DOMAIN - TSLP NGRE COMPLEX
Descriptor:Glucocorticoid receptor, DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), ...
Authors:Hudson, W.H., Youn, C.E., Ortlund, E.A.
Deposit date:2012-10-18
Release date:2012-12-12
Last modified:2013-01-16
Method:X-RAY DIFFRACTION (1.902 Å)
Cite:The structural basis of direct glucocorticoid-mediated transrepression.
Nat.Struct.Mol.Biol., 20, 2013
4HN6
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GR DNA BINDING DOMAIN R460D/D462R - TSLP NGRE COMPLEX
Descriptor:Glucocorticoid receptor, DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), ...
Authors:Hudson, W.H., Youn, C.E., Ortlund, E.A.
Deposit date:2012-10-18
Release date:2012-12-12
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (2.549 Å)
Cite:The structural basis of direct glucocorticoid-mediated transrepression.
Nat.Struct.Mol.Biol., 20, 2013
4MCE
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CRYSTAL STRUCTURE OF THE GAS5 GRE MIMIC
Descriptor:Gas5 GREM Fwd, Gas5 GREM Rev, SULFATE ION
Authors:Hudson, W.H., Ortlund, E.A.
Deposit date:2013-08-21
Release date:2014-09-24
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (2.205 Å)
Cite:Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.
Nat Commun, 5, 2014
4MCF
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CRYSTAL STRUCTURE OF THE GAS5 GRE MIMIC
Descriptor:Gas5 GREM Fwd, Gas5 GREM Rev, SULFATE ION
Authors:Hudson, W.H., Ortlund, E.A.
Deposit date:2013-08-21
Release date:2014-11-12
Last modified:2018-03-28
Method:X-RAY DIFFRACTION (1.899 Å)
Cite:Conserved sequence-specific lincRNA-steroid receptor interactions drive transcriptional repression and direct cell fate.
Nat Commun, 5, 2014
4TNT
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STRUCTURE OF THE HUMAN MINERALOCORTICOID RECEPTOR IN COMPLEX WITH DNA
Descriptor:Mineralocorticoid receptor, DNA (5'-D(*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H., Ortlund, E.A.
Deposit date:2014-06-04
Release date:2014-09-17
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.3938 Å)
Cite:Crystal structure of the mineralocorticoid receptor DNA binding domain in complex with DNA.
Plos One, 9, 2014
5CBX
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ANCGR DNA BINDING DOMAIN - (+)GRE COMPLEX
Descriptor:AncGR DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H., Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CBY
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ANCGR2 DNA BINDING DOMAIN - (+)GRE COMPLEX
Descriptor:AncGR2 DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H., Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.997 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CBZ
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ANCMR DNA BINDING DOMAIN - (+)GRE COMPLEX
Descriptor:AncMR DNA Binding Domain, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H., Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CC0
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ANCSR2 - TSLP NGRE COMPLEX
Descriptor:AncSR2 DNA Binding Domain, DNA (5'-D(*CP*GP*CP*CP*TP*CP*CP*GP*GP*GP*AP*GP*AP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*TP*CP*TP*CP*CP*CP*GP*GP*AP*GP*GP*CP*G)-3'), ...
Authors:Hudson, W.H., Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.405 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5CC1
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S425G GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - (+)GRE COMPLEX
Descriptor:Glucocorticoid receptor, DNA (5'-D(*CP*CP*AP*GP*AP*AP*CP*AP*GP*AP*GP*TP*GP*TP*TP*CP*TP*G)-3'), DNA (5'-D(*TP*CP*AP*GP*AP*AP*CP*AP*CP*TP*CP*TP*GP*TP*TP*CP*TP*G)-3'), ...
Authors:Hudson, W.H., Weikum, E.A., Ortlund, E.A.
Deposit date:2015-07-01
Release date:2015-12-23
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (2.302 Å)
Cite:Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Proc.Natl.Acad.Sci.USA, 113, 2016
5E69
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GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - IL8 NF-KB RESPONSE ELEMENT COMPLEX
Descriptor:Glucocorticoid receptor, DNA (5'-D(*GP*AP*GP*GP*AP*AP*AP*TP*TP*CP*CP*AP*CP*GP*AP*T)-3'), DNA (5'-D(*AP*TP*CP*GP*TP*GP*GP*AP*AP*TP*TP*TP*CP*CP*TP*C)-3'), ...
Authors:Hudson, W.H., Rye, E.A., Herbst, A.G., Ortlund, E.A.
Deposit date:2015-10-09
Release date:2017-02-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
5E6A
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GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - PLAU NF-KB RESPONSE ELEMENT COMPLEX
Descriptor:Glucocorticoid receptor, DNA (5'-D(*CP*TP*GP*GP*GP*AP*AP*TP*TP*TP*CP*CP*TP*GP*AP*T)-3'), DNA (5'-D(*AP*TP*CP*AP*GP*GP*AP*AP*AP*TP*TP*CP*CP*CP*AP*G)-3'), ...
Authors:Hudson, W.H., Rye, E.A., Herbst, A.G., Ortlund, E.A.
Deposit date:2015-10-09
Release date:2017-02-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.197 Å)
Cite:Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
5E6B
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GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - RELB NF-KB RESPONSE ELEMENT COMPLEX
Descriptor:Glucocorticoid receptor, DNA (5'-D(*CP*GP*GP*CP*GP*GP*AP*AP*TP*TP*CP*CP*CP*CP*GP*G)-3'), DNA (5'-D(*CP*CP*GP*GP*GP*GP*AP*AP*TP*TP*CP*CP*GP*CP*CP*G)-3'), ...
Authors:Hudson, W.H., Rye, E.A., Herbst, A.G., Ortlund, E.A.
Deposit date:2015-10-09
Release date:2017-02-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.25 Å)
Cite:Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
5E6C
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GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - CCL2 NF-KB RESPONSE ELEMENT COMPLEX
Descriptor:Glucocorticoid receptor, DNA (5'-D(*AP*GP*TP*GP*GP*AP*AP*AP*TP*TP*CP*CP*CP*AP*CP*T)-3'), DNA (5'-D(*AP*GP*TP*GP*GP*GP*AP*AP*TP*TP*TP*CP*CP*AP*CP*T)-3'), ...
Authors:Hudson, W.H., Rye, E.A., Herbst, A.G., Ortlund, E.A.
Deposit date:2015-10-09
Release date:2017-02-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
5E6D
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GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - ICAM1 NF-KB RESPONSE ELEMENT COMPLEX
Descriptor:DNA (5'-D(*GP*CP*TP*CP*CP*GP*GP*AP*AP*TP*TP*TP*CP*CP*AP*A)-3'), DNA (5'-D(*TP*TP*GP*GP*AP*AP*AP*TP*TP*CP*CP*GP*GP*AP*GP*C)-3'), Glucocorticoid receptor, ...
Authors:Hudson, W.H., Rye, E.A., Herbst, A.G., Ortlund, E.A.
Deposit date:2015-10-09
Release date:2017-02-08
Last modified:2018-10-24
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Cryptic glucocorticoid receptor-binding sites pervade genomic NF-kappa B response elements.
Nat Commun, 9, 2018
4DOR
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HUMAN NUCLEAR RECEPTOR LIVER RECEPTOR HOMOLOGUE-1, LRH-1, IN ITS APO STATE BOUND TO A FRAGMENT OF HUMAN SHP BOX1
Descriptor:Nuclear receptor subfamily 5 group A member 2, Nuclear receptor subfamily 0 group B member 2, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE
Authors:Musille, P.M., Ortlund, E.A.
Deposit date:2012-02-10
Release date:2012-04-18
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.
Nat.Struct.Mol.Biol., 19, 2012
4DOS
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HUMAN NUCLEAR RECEPTOR LIVER RECEPTOR HOMOLOGUE-1, LRH-1, BOUND TO DLPC AND A FRAGMENT OF TIF-2
Descriptor:Nuclear receptor subfamily 5 group A member 2, Nuclear receptor coactivator 2, PENTAETHYLENE GLYCOL, ...
Authors:Musille, P.M., Ortlund, E.A.
Deposit date:2012-02-10
Release date:2012-04-18
Last modified:2012-05-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.
Nat.Struct.Mol.Biol., 19, 2012
5VA0
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GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN IN COMPLEX WITH AP-1 RESPONSE ELEMENT FROM VCAM-1 PROMOTER
Descriptor:Glucocorticoid receptor, DNA (5'-D(*CP*GP*GP*CP*TP*GP*AP*CP*TP*CP*AP*TP*CP*AP*AP*G)-3'), DNA (5'-D(*CP*TP*TP*GP*AP*TP*GP*AP*GP*TP*CP*AP*GP*CP*CP*G)-3'), ...
Authors:Weikum, E.R., Ortlund, E.A.
Deposit date:2017-03-24
Release date:2017-08-09
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.295 Å)
Cite:Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.
Nucleic Acids Res., 45, 2017
5VA7
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GLUCOCORTICOID RECEPTOR DNA BINDING DOMAIN - IL11 AP-1 RECOGNITION ELEMENT COMPLEX
Descriptor:Glucocorticoid receptor, DNA (5'-D(*AP*GP*GP*GP*TP*GP*AP*GP*TP*CP*AP*GP*GP*AP*TP*G)-3'), DNA (5'-D(*CP*AP*TP*CP*CP*TP*GP*AP*CP*TP*CP*AP*CP*CP*CP*T)-3'), ...
Authors:Weikum, E.R., Ortlund, E.A.
Deposit date:2017-03-24
Release date:2017-08-09
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.153 Å)
Cite:Tethering not required: the glucocorticoid receptor binds directly to activator protein-1 recognition motifs to repress inflammatory genes.
Nucleic Acids Res., 45, 2017
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