Human Nuclear Receptor Liver Receptor Homologue-1, LRH-1, in its apo State Bound to a Fragment of Human SHP Box1

Summary for 4DOR

DescriptorNuclear receptor subfamily 5 group A member 2, Nuclear receptor subfamily 0 group B member 2, L-ALPHA-PHOSPHATIDYL-BETA-OLEOYL-GAMMA-PALMITOYL-PHOSPHATIDYLETHANOLAMINE, ... (4 entities in total)
Functional Keywordsnuclear receptor, ligand binding domain, phospholipids, nr5a, diabetes, phosphatidylcholine, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus  O00482 Q15466
Total number of polymer chains4
Total molecular weight62529.06
Musille, P.M.,Ortlund, E.A. (deposition date: 2012-02-10, release date: 2012-04-18, Last modification date: 2017-11-15)
Primary citation
Musille, P.M.,Pathak, M.C.,Lauer, J.L.,Hudson, W.H.,Griffin, P.R.,Ortlund, E.A.
Antidiabetic phospholipid-nuclear receptor complex reveals the mechanism for phospholipid-driven gene regulation.
Nat.Struct.Mol.Biol., 19:532-537, 2012
PubMed: 22504882 (PDB entries with the same primary citation)
DOI: 10.1038/nsmb.2279
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.227701.6%4.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4dor
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Molmil generated image of 4dor
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Molmil generated image of 4dor
rotated about y axis by 90°