Author results

5K3N
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CRYSTAL STRUCTURE OF RETINOIC ACID RECEPTOR-RELATED ORPHAN RECEPTOR (ROR) GAMMA LIGAND BINDING DOMAIN COMPLEX WITH ML209
Descriptor:Nuclear receptor ROR-gamma, (3S)-3-(2H-1,3-benzodioxol-5-yl)-1-[(3R,5S)-3,5-dimethylpiperidin-1-yl]-3-(2-hydroxy-4,6-dimethoxyphenyl)propan-1-one
Authors:Huang, P., Rastinejad, F., Lu, J.
Deposit date:2016-05-19
Release date:2017-05-31
Method:X-RAY DIFFRACTION (2.666 Å)
Cite:Crystal structure of Retinoic acid receptor-related orphan receptor (ROR) gamma ligand binding domain complex with ML209
To be published
5KZV
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CRYSTAL STRUCTURE OF THE XENOPUS SMOOTHENED CYSTEINE-RICH DOMAIN (CRD) IN COMPLEX WITH 20(S)-HYDROXYCHOLESTEROL
Descriptor:Smoothened, (3alpha,8alpha)-cholest-5-ene-3,20-diol
Authors:Huang, P., Kim, Y., Salic, A.
Deposit date:2016-07-25
Release date:2016-08-17
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.616 Å)
Cite:Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Cell, 166, 2016
5KZY
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CRYSTAL STRUCTURE OF THE XENOPUS SMOOTHENED CYSTEINE-RICH DOMAIN (CRD) IN COMPLEX WITH CYCLOPAMINE
Descriptor:Smoothened, Cyclopamine
Authors:Huang, P., Kim, Y., Salic, A.
Deposit date:2016-07-25
Release date:2016-08-17
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (2.484 Å)
Cite:Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Cell, 166, 2016
5KZZ
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CRYSTAL STRUCTURE OF THE XENOPUS SMOOTHENED CYSTEINE-RICH DOMAIN (CRD) IN ITS APO-FORM
Descriptor:Smoothened, ACETATE ION, ZINC ION, ...
Authors:Huang, P., Kim, Y., Salic, A.
Deposit date:2016-07-25
Release date:2016-08-17
Last modified:2017-09-06
Method:X-RAY DIFFRACTION (1.332 Å)
Cite:Cellular Cholesterol Directly Activates Smoothened in Hedgehog Signaling.
Cell, 166, 2016
6D32
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CRYSTAL STRUCTURE OF XENOPUS SMOOTHENED IN COMPLEX WITH CYCLOPAMINE
Descriptor:Smoothened,Soluble cytochrome b562,Smoothened, Cyclopamine
Authors:Huang, P., Zheng, S., Kim, Y., Kruse, A.C., Salic, A.
Deposit date:2018-04-14
Release date:2018-05-23
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (3.751 Å)
Cite:Structural Basis of Smoothened Activation in Hedgehog Signaling.
Cell, 174, 2018
6D35
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CRYSTAL STRUCTURE OF XENOPUS SMOOTHENED IN COMPLEX WITH CHOLESTEROL
Descriptor:Smoothened,Soluble cytochrome b562,Smoothened, CHOLESTEROL
Authors:Huang, P., Zheng, S., Kim, Y., Kruse, A.C., Salic, A.
Deposit date:2018-04-14
Release date:2018-05-23
Last modified:2018-07-25
Method:X-RAY DIFFRACTION (3.9 Å)
Cite:Structural Basis of Smoothened Activation in Hedgehog Signaling.
Cell, 174, 2018
6OMT
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HIV-1 CAPSID HEXAMER R18D MUTANT
Descriptor:Capsid protein
Authors:Huang, P., Summers, B.J., Xiong, Y.
Deposit date:2019-04-19
Release date:2019-08-21
Last modified:2019-11-27
Method:X-RAY DIFFRACTION (2.052 Å)
Cite:FEZ1 Is Recruited to a Conserved Cofactor Site on Capsid to Promote HIV-1 Trafficking.
Cell Rep, 28, 2019
4S14
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CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR RORGAMMA LIGAND-BINDING DOMAIN IN COMPLEX WITH 4ALPHA-CABOXYL, 4BETA-METHYL-ZYMOSTEROL (4ACD8)
Descriptor:Nuclear receptor ROR-gamma, Nuclear receptor-interacting protein 1, (3beta,4alpha,5beta,14beta)-3-hydroxy-4-methylcholesta-8,24-diene-4-carboxylic acid
Authors:Huang, P., Santori, F.R., Littman, D.R., Rastinejad, F.
Deposit date:2015-01-07
Release date:2015-02-11
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (3.542 Å)
Cite:Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells.
Cell Metab, 21, 2015
4S15
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CRYSTAL STRUCTURE OF THE ORPHAN NUCLEAR RECEPTOR RORALPHA LIGAND-BINDING DOMAIN IN COMPLEX WITH 4ALPHA-CABOXYL, 4BETA-METHYL-ZYMOSTEROL (4ACD8)
Descriptor:Nuclear receptor ROR-alpha, Nuclear receptor-interacting protein 1, (3beta,4alpha,5beta,14beta)-3-hydroxy-4-methylcholesta-8,24-diene-4-carboxylic acid, ...
Authors:Huang, P., Santori, F.R., Littman, D.R., Rastinejad, F.
Deposit date:2015-01-08
Release date:2015-02-11
Last modified:2015-02-25
Method:X-RAY DIFFRACTION (1.897 Å)
Cite:Identification of Natural ROR gamma Ligands that Regulate the Development of Lymphoid Cells.
Cell Metab, 21, 2015
4UOS
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THERMODYNAMIC HYPERSTABILITY IN PARAMETRICALLY DESIGNED HELICAL BUNDLES
Descriptor:DESIGNED HELICAL BUNDLE
Authors:Oberdorfer, G., Huang, P., Pei, X.Y., Xu, C., Gonen, T., Nannenga, B., DiMaio, D., Rogers, J., Luisi, B.F., Baker, D.
Deposit date:2014-06-09
Release date:2014-11-05
Last modified:2016-12-14
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:High Thermodynamic Stability of Parametrically Designed Helical Bundles
Science, 346, 2014
4UOT
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THERMODYNAMIC HYPERSTABILITY IN PARAMETRICALLY DESIGNED HELICAL BUNDLES
Descriptor:DESIGNED HELICAL BUNDLE 5H2L
Authors:Oberdorfer, G., Huang, P., Pei, X.Y., Xu, C., Gonen, T., Nannenga, B., DiMaio, D., Rogers, J., Luisi, B.F., Baker, D.
Deposit date:2014-06-09
Release date:2014-11-05
Last modified:2014-11-19
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:High Thermodynamic Stability of Parametrically Designed Helical Bundles
Science, 346, 2014
5WUG
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EXPRESSION, CHARACTERIZATION AND CRYSTAL STRUCTURE OF A NOVEL BETA-GLUCOSIDASE FROM PAENIBACILLUS BARENGOLTZII
Descriptor:Beta-glucosidase
Authors:Jiang, Z., Wu, S., Yang, D., Qin, Z., You, X., Huang, P.
Deposit date:2016-12-17
Release date:2018-01-31
Last modified:2019-08-21
Method:X-RAY DIFFRACTION (2.216 Å)
Cite:Expression, Biochemical Characterization and Structure Resolution of beta-glucosidase from Paenibacillus barengoltzii
J Food Sci Technol(China), 2019
5Z0Q
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CRYSTAL STRUCTURE OF OVOB
Descriptor:Aminotransferase, class I and II, PYRIDOXAL-5'-PHOSPHATE
Authors:Cai, Y.J., Huang, P., Wu, L., Zhou, J.H., Liu, P.H.
Deposit date:2017-12-20
Release date:2018-11-07
Method:X-RAY DIFFRACTION (2.77 Å)
Cite:In Vitro Reconstitution of the Remaining Steps in Ovothiol A Biosynthesis: C-S Lyase and Methyltransferase Reactions.
Org. Lett., 20, 2018
1PF8
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CRYSTAL STRUCTURE OF HUMAN CYCLIN-DEPENDENT KINASE 2 COMPLEXED WITH A NUCLEOSIDE INHIBITOR
Descriptor:Cell division protein kinase 2, (3Z)-3-(1H-IMIDAZOL-5-YLMETHYLENE)-5-METHOXY-1H-INDOL-2(3H)-ONE
Authors:Moshinsky, D.J., Bellamacina, R.C., Boisvert, D.C., Huang, P., Hui, T., Jancarik, J., Kim, S.H., Rice, A.G.
Deposit date:2003-05-24
Release date:2003-12-23
Last modified:2014-04-16
Method:X-RAY DIFFRACTION (2.51 Å)
Cite:SU9516: biochemical analysis of cdk inhibition and crystal structure in complex with cdk2.
Biochem.Biophys.Res.Commun., 310, 2003
2MP0
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PROTEIN PHOSPHORYLATION UPON A FLEETING ENCOUNTER
Descriptor:Phosphoenolpyruvate-protein phosphotransferase, Glucose-specific phosphotransferase enzyme IIA component, PHOSPHITE ION
Authors:Xing, Q., Yang, J., Huang, P., Zhang, W., Tang, C.
Deposit date:2014-05-08
Release date:2014-08-20
Method:SOLUTION NMR
Cite:Visualizing an Ultra-Weak Protein-Protein Interaction in Phosphorylation Signaling
Angew.Chem.Int.Ed.Engl., 2014
3DZU
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INTACT PPAR GAMMA - RXR ALPHA NUCLEAR RECEPTOR COMPLEX ON DNA BOUND WITH BVT.13, 9-CIS RETINOIC ACID AND NCOA2 PEPTIDE
Descriptor:Retinoic acid receptor RXR-alpha, Peroxisome proliferator-activated receptor gamma, DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3'), ...
Authors:Chandra, V., Huang, P., Hamuro, Y., Raghuram, S., Wang, Y., Burris, T.P., Rastinejad, F.
Deposit date:2008-07-30
Release date:2008-10-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.2 Å)
Cite:Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.
Nature, 456, 2008
3DZY
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INTACT PPAR GAMMA - RXR ALPHA NUCLEAR RECEPTOR COMPLEX ON DNA BOUND WITH ROSIGLITAZONE, 9-CIS RETINOIC ACID AND NCOA2 PEPTIDE
Descriptor:Retinoic acid receptor RXR-alpha, Peroxisome proliferator-activated receptor gamma, DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3'), ...
Authors:Chandra, V., Huang, P., Hamuro, Y., Raghuram, S., Wang, Y., Burris, T.P., Rastinejad, F.
Deposit date:2008-07-30
Release date:2008-10-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.
Nature, 456, 2008
3E00
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INTACT PPAR GAMMA - RXR ALPHA NUCLEAR RECEPTOR COMPLEX ON DNA BOUND WITH GW9662, 9-CIS RETINOIC ACID AND NCOA2 PEPTIDE
Descriptor:Retinoic acid receptor RXR-alpha, Peroxisome proliferator-activated receptor gamma, DNA (5'-D(*DCP*DAP*DAP*DAP*DCP*DTP*DAP*DGP*DGP*DTP*DCP*DAP*DAP*DAP*DGP*DGP*DTP*DCP*DAP*DG)-3'), ...
Authors:Chandra, V., Huang, P., Hamuro, Y., Raghuram, S., Wang, Y., Burris, T.P., Rastinejad, F.
Deposit date:2008-07-30
Release date:2008-10-28
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:Structure of the intact PPAR-gamma-RXR- nuclear receptor complex on DNA.
Nature, 456, 2008
3M9Q
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DROSOPHILA MSL3 CHROMODOMAIN
Descriptor:Protein male-specific lethal-3
Authors:Kim, D., Huang, P., Rastinejad, F., Khorasanizadeh, S.
Deposit date:2010-03-22
Release date:2010-07-21
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.29 Å)
Cite:Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain.
Nat.Struct.Mol.Biol., 17, 2010
3OA6
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HUMAN MSL3 CHROMODOMAIN BOUND TO DNA AND H4K20ME1 PEPTIDE
Descriptor:Male-specific lethal 3 homolog, DNA (5'-D(*GP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*A)-3'), DNA (5'-D(*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*G)-3'), ...
Authors:Kim, D., Huang, P., Rastinejad, F., Khorasanizadeh, S.
Deposit date:2010-08-04
Release date:2010-08-18
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Corecognition of DNA and a methylated histone tail by the MSL3 chromodomain.
Nat.Struct.Mol.Biol., 17, 2010
3PUM
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CRYSTAL STRUCTURE OF P DOMAIN DIMER OF NOROVIRUS VA207
Descriptor:Capsid
Authors:Chen, Y., Tan, M., Xia, M., Hao, N., Zhang, X.C., Huang, P., Jiang, X., Li, X., Rao, Z.
Deposit date:2010-12-06
Release date:2011-08-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.252 Å)
Cite:Crystallography of a Lewis-binding norovirus, elucidation of strain-specificity to the polymorphic human histo-blood group antigens
Plos Pathog., 7, 2011
3PUN
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CRYSTAL STRUCTURE OF P DOMAIN DIMER OF NOROVIRUS VA207 WITH LEWIS Y TETRASACCHARIDE
Descriptor:Capsid, ALPHA-L-FUCOSE, BETA-D-GALACTOSE, ...
Authors:Chen, Y., Tan, M., Xia, M., Hao, N., Zhang, X.C., Huang, P., Jiang, X., Li, X., Rao, Z.
Deposit date:2010-12-06
Release date:2011-08-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:Crystallography of a Lewis-binding norovirus, elucidation of strain-specificity to the polymorphic human histo-blood group antigens
Plos Pathog., 7, 2011
3PVD
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CRYSTAL STRUCTURE OF P DOMAIN DIMER OF NOROVIRUS VA207 COMPLEXED WITH 3'-SIALYL-LEWIS X TETRASACCHARIDE
Descriptor:Capsid, O-SIALIC ACID, BETA-D-GALACTOSE, ...
Authors:Chen, Y., Tan, M., Xia, M., Hao, N., Zhang, X.C., Huang, P., Jiang, X., Li, X., Rao, Z.
Deposit date:2010-12-06
Release date:2011-08-03
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystallography of a Lewis-binding norovirus, elucidation of strain-specificity to the polymorphic human histo-blood group antigens
Plos Pathog., 7, 2011
4IQR
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MULTI-DOMAIN ORGANIZATION OF THE HNF4ALPHA NUCLEAR RECEPTOR COMPLEX ON DNA
Descriptor:Hepatocyte nuclear factor 4-alpha, DNA (5'-D(*GP*GP*AP*AP*CP*TP*AP*GP*GP*TP*CP*AP*AP*AP*GP*GP*TP*CP*AP*G)-3'), DNA (5'-D(*CP*CP*TP*GP*AP*CP*CP*TP*TP*TP*GP*AP*CP*CP*TP*AP*GP*TP*TP*C)-3'), ...
Authors:Chandra, V., Huang, P., Kim, Y., Rastinejad, F.
Deposit date:2013-01-13
Release date:2013-03-20
Last modified:2013-10-23
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Multidomain integration in the structure of the HNF-4 alpha nuclear receptor complex.
Nature, 495, 2013
5GM1
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CRYSTAL STRUCTURE OF METHYLTRANSFERASE TLED COMPLEXED WITH SAH
Descriptor:O-methylransferase, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Yu, F., Li, M.J., Xu, C.Y., Zhou, H., Sun, B., Wang, Z.J., Xu, Q., Xie, M.Y., Zuo, G., Huang, P., Wang, Q.S., He, J.H.
Deposit date:2016-07-12
Release date:2016-09-28
Last modified:2016-12-07
Method:X-RAY DIFFRACTION (2.501 Å)
Cite:Crystal structure and enantioselectivity of terpene cyclization in SAM-dependent methyltransferase TleD
Biochem.J., 473, 2016
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