Author results

5D9Y
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CRYSTAL STRUCTURE OF TET2-5FC COMPLEX
Descriptor:Methylcytosine dioxygenase TET2,Methylcytosine dioxygenase TET2, DNA (5'-D(*AP*CP*TP*GP*TP*(5FC)P*GP*AP*AP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*TP*TP*CP*GP*AP*CP*AP*GP*T)-3'), ...
Authors:Hu, L., Cheng, J., Rao, Q., Li, Z., Li, J., Xu, Y.
Deposit date:2015-08-19
Release date:2015-11-04
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (1.971 Å)
Cite:Structural insight into substrate preference for TET-mediated oxidation.
Nature, 527, 2015
5DEU
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CRYSTAL STRUCTURE OF TET2-5HMC COMPLEX
Descriptor:Methylcytosine dioxygenase TET2, chimeric construct, DNA (5'-D(*AP*CP*CP*AP*CP*(5HC)P*GP*GP*TP*GP*GP*T)-3'), ...
Authors:Hu, L., Cheng, J., Rao, Q., Li, Z., Li, J., Xu, Y.
Deposit date:2015-08-26
Release date:2015-11-04
Last modified:2015-11-18
Method:X-RAY DIFFRACTION (1.801 Å)
Cite:Structural insight into substrate preference for TET-mediated oxidation.
Nature, 527, 2015
2KOW
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STRUCTURE OF A TWO-G-TETRAD BASKET-TYPE INTRAMOLECULAR G-QUADRUPLEX FORMED BY GIARDIA TELOMERIC REPEAT D(TAGGG)4 IN K+ SOLUTION (WITH G18-TO-INO SUBSTITUTION)
Descriptor:DNA (5'-D(*TP*AP*GP*GP*GP*TP*AP*GP*GP*GP*TP*AP*GP*GP*GP*TP*AP*IP*GP*G)-3')
Authors:Hu, L., Lim, K.W., Bouaziz, S., Phan, A.T.
Deposit date:2009-10-02
Release date:2009-11-17
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Giardia Telomeric Sequence d(TAGGG)(4) Forms Two Intramolecular G-Quadruplexes in K(+) Solution: Effect of Loop Length and Sequence on the Folding Topology.
J.Am.Chem.Soc., 131, 2009
3SHB
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CRYSTAL STRUCTURE OF PHD DOMAIN OF UHRF1
Descriptor:E3 ubiquitin-protein ligase UHRF1, Histone H3 peptide, ZINC ION
Authors:Hu, L., Li, Z., Wang, P., Lin, Y., Xu, Y.
Deposit date:2011-06-16
Release date:2011-08-24
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of PHD domain of UHRF1 and insights into recognition of unmodified histone H3 arginine residue 2.
Cell Res., 2011
4DRR
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CELL ATTACHMENT PROTEIN VP8* OF A HUMAN ROTAVIRUS SPECIFICALLY INTERACTS WITH A-TYPE HISTO-BLOOD GROUP ANTIGEN
Descriptor:Outer capsid protein VP4, SODIUM ION
Authors:Hu, L., Crawford, S.E., Czako, R., Cortes-Penfield, N.W., Smith, D.F., Le Pendu, J., Estes, M.K., Prasad, B.V.V.
Deposit date:2012-02-17
Release date:2012-04-11
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen.
Nature, 485, 2012
4DRV
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CELL ATTACHMENT PROTEIN VP8* OF A HUMAN ROTAVIRUS SPECIFICALLY INTERACTS WITH A-TYPE HISTO-BLOOD GROUP ANTIGEN
Descriptor:Outer capsid protein VP4, N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE, ALPHA D-GALACTOSE, ...
Authors:Hu, L., Crawford, S.E., Czako, R., Cortes-Penfield, N.W., Smith, D.F., Le Pendu, J., Estes, M.K., Prasad, B.V.V.
Deposit date:2012-02-17
Release date:2012-04-11
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen.
Nature, 485, 2012
4DS0
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CELL ATTACHMENT PROTEIN VP8* OF A HUMAN ROTAVIRUS SPECIFICALLY INTERACTS WITH A-TYPE HISTO-BLOOD GROUP ANTIGEN
Descriptor:Outer capsid protein VP4, N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE, BETA-D-GALACTOSE, ...
Authors:Hu, L., Crawford, S.E., Czako, R., Cortes-Penfield, N.W., Smith, D.F., Le Pendu, J., Estes, M.K., Prasad, B.V.V.
Deposit date:2012-02-17
Release date:2012-04-11
Last modified:2012-05-23
Method:X-RAY DIFFRACTION (1.56 Å)
Cite:Cell attachment protein VP8* of a human rotavirus specifically interacts with A-type histo-blood group antigen.
Nature, 485, 2012
4G0A
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CRYSTALLOGRAPHIC ANALYSIS OF ROTAVIRUS NSP2-RNA COMPLEX REVEALS SPECIFIC RECOGNITION OF 5'-GG SEQUENCE FOR RTPASE ACTIVITY
Descriptor:Non-structural protein 2, RNA (5'-R(P*GP*GP*U)-3'), CHLORIDE ION, ...
Authors:Hu, L., Prasad, B.V.V.
Deposit date:2012-07-09
Release date:2012-08-22
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (2.0995 Å)
Cite:Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase Activity.
J.Virol., 86, 2012
4G0J
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CRYSTALLOGRAPHIC ANALYSIS OF ROTAVIRUS NSP2-RNA COMPLEX REVEALS SPECIFIC RECOGNITION OF 5'-GG SEQUENCE FOR RTPASE ACTIVITY
Descriptor:Non-structural protein 2
Authors:Hu, L., Prasad, B.V.V.
Deposit date:2012-07-09
Release date:2012-08-22
Last modified:2012-09-26
Method:X-RAY DIFFRACTION (3.398 Å)
Cite:Crystallographic Analysis of Rotavirus NSP2-RNA Complex Reveals Specific Recognition of 5' GG Sequence for RTPase Activity.
J.Virol., 86, 2012
4NM6
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CRYSTAL STRUCTURE OF TET2-DNA COMPLEX
Descriptor:Methylcytosine dioxygenase TET2, 5'-D(*AP*CP*CP*AP*CP*(5CM)P*GP*GP*TP*GP*GP*T)-3', ZINC ION, ...
Authors:Hu, L., Li, Z., Cheng, J., Rao, Q., Gong, W., Liu, M., Wang, P., Xu, Y.
Deposit date:2013-11-14
Release date:2013-12-18
Last modified:2017-07-26
Method:X-RAY DIFFRACTION (2.026 Å)
Cite:Crystal Structure of TET2-DNA Complex: Insight into TET-Mediated 5mC Oxidation.
Cell(Cambridge,Mass.), 155, 2013
4YFW
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STRUCTURAL BASIS OF GLYCAN RECOGNITION IN NEONATE-SPECIFIC ROTAVIRUSES
Descriptor:Outer capsid protein VP4
Authors:Hu, L., Prasad, B.V.V.
Deposit date:2015-02-25
Release date:2015-09-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus.
Nat Commun, 6, 2015
4YFZ
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STRUCTURAL BASIS OF GLYCAN RECOGNITION IN NEONATE-SPECIFIC ROTAVIRUSES
Descriptor:Outer capsid protein VP4, BETA-D-GALACTOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hu, L., Prasad, B.V.V.
Deposit date:2015-02-25
Release date:2015-09-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus.
Nat Commun, 6, 2015
4YG0
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STRUCTURAL BASIS OF GLYCAN RECOGNITION IN NEONATE-SPECIFIC ROTAVIRUSES
Descriptor:Outer capsid protein VP4, BETA-D-GALACTOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hu, L., Prasad, B.V.V.
Deposit date:2015-02-25
Release date:2015-09-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.285 Å)
Cite:Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus.
Nat Commun, 6, 2015
4YG3
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STRUCTURAL BASIS OF GLYCAN RECOGNITION IN NEONATE-SPECIFIC ROTAVIRUSES
Descriptor:Outer capsid protein VP4, SULFATE ION
Authors:Hu, L., Prasad, B.V.V.
Deposit date:2015-02-25
Release date:2015-09-30
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (2.285 Å)
Cite:Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus.
Nat Commun, 6, 2015
4YG6
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STRUCTURAL BASIS OF GLYCAN RECOGNITION IN NEONATE-SPECIFIC ROTAVIRUSES
Descriptor:Outer capsid protein VP8*, BETA-D-GALACTOSE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Hu, L., Prasad, B.V.V.
Deposit date:2015-02-25
Release date:2015-09-30
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (1.46 Å)
Cite:Structural basis of glycan specificity in neonate-specific bovine-human reassortant rotavirus.
Nat Commun, 6, 2015
5VX4
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VP8* OF A G2P[4] HUMAN ROTAVIRUS
Descriptor:Outer capsid protein VP4, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL
Authors:Hu, L., Venkataram Prasad, B.V.
Deposit date:2017-05-23
Release date:2018-07-18
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Glycan recognition in globally dominant human rotaviruses.
Nat Commun, 9, 2018
5VX5
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VP8* OF A G2P[4] HUMAN ROTAVIRUS IN COMPLEX WITH LNFP1
Descriptor:Outer capsid protein VP4, ALPHA-L-FUCOSE, BETA-D-GALACTOSE, ...
Authors:Hu, L., Venkataram Prasad, B.V.
Deposit date:2017-05-23
Release date:2018-07-18
Method:X-RAY DIFFRACTION (1.285 Å)
Cite:Glycan recognition in globally dominant human rotaviruses.
Nat Commun, 9, 2018
5VX8
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VP8* OF P[6] HUMAN ROTAVIRUS RV3
Descriptor:Outer capsid protein VP4, SULFATE ION
Authors:Hu, L., Venkataram Prasad, B.V.
Deposit date:2017-05-23
Release date:2018-07-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Glycan recognition in globally dominant human rotaviruses.
Nat Commun, 9, 2018
5VX9
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VP8* OF P[6] HUMAN ROTAVIRUS RV3 IN COMPLEX WITH LNFP1
Descriptor:Outer capsid protein VP4, ALPHA-L-FUCOSE, BETA-D-GALACTOSE, ...
Authors:Hu, L., Venkataram Prasad, B.V.
Deposit date:2017-05-23
Release date:2018-07-18
Method:X-RAY DIFFRACTION (1.822 Å)
Cite:Glycan recognition in globally dominant human rotaviruses.
Nat Commun, 9, 2018
4JW1
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CRYSTAL STRUCTURE OF N-TERMINAL 618-RESIDUE FRAGMENT OF LEPB FROM LEGIONELLA PNEUMOPHILA
Descriptor:Effector protein B, GLYCEROL, CITRATE ANION
Authors:Hu, L., Yao, Q., Zhu, Y., Shao, F.
Deposit date:2013-03-26
Release date:2013-05-08
Last modified:2013-08-14
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Structural analyses of Legionella LepB reveal a new GAP fold that catalytically mimics eukaryotic RasGAP
Cell Res., 23, 2013
4RPT
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THE 1.35A STRUCTURE OF A VIRAL RNASE L ANTAGONIST REVEALS BASIS FOR THE 2'-5'-OLIGOADENYLATE BINDING AND ENZYME ACTIVITY.
Descriptor:Capping enzyme protein, MALONATE ION, 1,2-ETHANEDIOL
Authors:Hu, L., Prasad, B.V.V.
Deposit date:2014-10-31
Release date:2015-04-29
Last modified:2015-08-19
Method:X-RAY DIFFRACTION (1.35 Å)
Cite:Structural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist.
J.Virol., 89, 2015
4YE2
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THE 1.35 STRUCTURE OF A VIRAL RNASE L ANTAGONIST REVEALS BASIS FOR THE 2'-5'-OLIGOADENYLATE BINDING AND ENZYME ACTIVITY.
Descriptor:Capping enzyme protein, ADENOSINE-2'-5'-DIPHOSPHATE, SULFATE ION
Authors:Hu, L., Prasad, B.V.V.
Deposit date:2015-02-23
Release date:2015-04-29
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (3.098 Å)
Cite:Structural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist.
J.Virol., 89, 2015
5VTH
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CTX-M-14 P167S:E166A MUTANT
Descriptor:Beta-lactamase
Authors:Hu, L., Patel, M., Prasad, B.V.V., Palzkill, T.
Deposit date:2017-05-17
Release date:2017-06-28
Last modified:2017-09-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The Drug-Resistant Variant P167S Expands the Substrate Profile of CTX-M beta-Lactamases for Oxyimino-Cephalosporin Antibiotics by Enlarging the Active Site upon Acylation.
Biochemistry, 56, 2017
6AUK
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CRYSTAL STRUCTURE OF ROTAVIRUS NON STRUCTURAL PROTEIN 2 (NSP2) MUTANT S313D
Descriptor:Non-structural protein 2, SULFATE ION, CHLORIDE ION
Authors:Hu, L., Prasad, B.V.
Deposit date:2017-09-01
Release date:2018-12-05
Last modified:2019-02-20
Method:X-RAY DIFFRACTION (2.603 Å)
Cite:Phosphorylation cascade regulates the formation and maturation of rotaviral replication factories.
Proc. Natl. Acad. Sci. U.S.A., 115, 2018
3NSP
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CRYSTAL STRUCTURE OF TETRAMERIC RXRALPHA-LBD
Descriptor:Retinoid X receptor, alpha
Authors:Zhang, H., Hu, T., Li, L., Zhou, R., Chen, L., Hu, L., Jiang, H., Shen, X.
Deposit date:2010-07-02
Release date:2010-11-17
Last modified:2012-04-11
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Danthron functions as a retinoic X receptor antagonist by stabilizing tetramers of the receptor.
J.Biol.Chem., 286, 2011