4YE2
The 1.35 structure of a viral RNase L antagonist reveals basis for the 2'-5'-oligoadenylate binding and enzyme activity.
Summary for 4YE2
Entry DOI | 10.2210/pdb4ye2/pdb |
Related | 4RPT 4YFW 4YFZ 4YG0 4YG3 4YG6 |
Descriptor | Capping enzyme protein, ADENOSINE-2'-5'-DIPHOSPHATE, SULFATE ION, ... (4 entities in total) |
Functional Keywords | innate immunity, rnase l, oligoadenylate, rotavirus, coronavirus, phosphodiesterase, viral protein |
Biological source | Rotavirus A |
Total number of polymer chains | 2 |
Total formula weight | 34056.22 |
Authors | Hu, L.,Sankaran, B.,Prasad, B.V.V. (deposition date: 2015-02-23, release date: 2015-04-29, Last modification date: 2023-09-27) |
Primary citation | Ogden, K.M.,Hu, L.,Jha, B.K.,Sankaran, B.,Weiss, S.R.,Silverman, R.H.,Patton, J.T.,Prasad, B.V. Structural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist. J.Virol., 89:6633-6645, 2015 Cited by PubMed: 25878106DOI: 10.1128/JVI.00701-15 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.098 Å) |
Structure validation
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