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4YE2

The 1.35 structure of a viral RNase L antagonist reveals basis for the 2'-5'-oligoadenylate binding and enzyme activity.

Summary for 4YE2
Entry DOI10.2210/pdb4ye2/pdb
Related4RPT 4YFW 4YFZ 4YG0 4YG3 4YG6
DescriptorCapping enzyme protein, ADENOSINE-2'-5'-DIPHOSPHATE, SULFATE ION, ... (4 entities in total)
Functional Keywordsinnate immunity, rnase l, oligoadenylate, rotavirus, coronavirus, phosphodiesterase, viral protein
Biological sourceRotavirus A
Total number of polymer chains2
Total formula weight34056.22
Authors
Hu, L.,Sankaran, B.,Prasad, B.V.V. (deposition date: 2015-02-23, release date: 2015-04-29, Last modification date: 2023-09-27)
Primary citationOgden, K.M.,Hu, L.,Jha, B.K.,Sankaran, B.,Weiss, S.R.,Silverman, R.H.,Patton, J.T.,Prasad, B.V.
Structural basis for 2'-5'-oligoadenylate binding and enzyme activity of a viral RNase L antagonist.
J.Virol., 89:6633-6645, 2015
Cited by
PubMed: 25878106
DOI: 10.1128/JVI.00701-15
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (3.098 Å)
Structure validation

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