Author results

1NAR
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CRYSTAL STRUCTURE OF NARBONIN REFINED AT 1.8 ANGSTROMS RESOLUTION
Descriptor:NARBONIN
Authors:Hennig, M., Schlesier, B., Wilson, K.S.
Deposit date:1993-09-10
Release date:1994-01-31
Last modified:2017-11-29
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of narbonin at 1.8 A resolution.
Acta Crystallogr.,Sect.D, 51, 1995
1A53
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COMPLEX OF INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS WITH INDOLE-3-GLYCEROLPHOSPHATE AT 2.0 A RESOLUTION
Descriptor:INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE, INDOLE-3-GLYCEROL PHOSPHATE
Authors:Hennig, M., Darimont, B., Kirschner, K., Jansonius, J.N.
Deposit date:1998-02-19
Release date:1999-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product.
J.Mol.Biol., 319, 2002
1CNV
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CRYSTAL STRUCTURE OF CONCANAVALIN B AT 1.65 A RESOLUTION
Descriptor:CONCANAVALIN B
Authors:Hennig, M.
Deposit date:1995-02-20
Release date:1996-03-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure of concanavalin B at 1.65 A resolution. An "inactivated" chitinase from seeds of Canavalia ensiformis.
J.Mol.Biol., 254, 1995
1NSJ
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CRYSTAL STRUCTURE OF PHOSPHORIBOSYL ANTHRANILATE ISOMERASE FROM THERMOTOGA MARITIMA
Descriptor:PHOSPHORIBOSYL ANTHRANILATE ISOMERASE, PHOSPHATE ION
Authors:Hennig, M., Jansonius, J.N.J.
Deposit date:1996-09-13
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Crystal structure at 2.0 A resolution of phosphoribosyl anthranilate isomerase from the hyperthermophile Thermotoga maritima: possible determinants of protein stability.
Biochemistry, 36, 1997
2GSA
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CRYSTAL STRUCTURE OF GLUTAMATE-1-SEMIALDEHYDE AMINOMUTASE (AMINOTRANSFERASE, WILD-TYPE FORM)
Descriptor:GLUTAMATE SEMIALDEHYDE AMINOTRANSFERASE, 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, PYRIDOXAL-5'-PHOSPHATE
Authors:Hennig, M., Jansonius, J.N.
Deposit date:1997-02-26
Release date:1998-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity.
Proc.Natl.Acad.Sci.USA, 94, 1997
3GSB
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CRYSTAL STRUCTURE OF GLUTAMATE-1-SEMIALDEHYDE AMINOMUTASE IN COMPLEX WITH GABACULINE
Descriptor:PROTEIN (GLUTAMATE SEMIALDEHYDE AMINOTRANSFERASE), 4'-DEOXY-4'-AMINOPYRIDOXAL-5'-PHOSPHATE, 3-AMINOBENZOIC ACID
Authors:Hennig, M., Jansonius, J.N.
Deposit date:1998-06-26
Release date:1999-08-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (3 Å)
Cite:Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity.
Proc.Natl.Acad.Sci.USA, 94, 1997
4GSA
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CRYSTAL STRUCTURE OF GLUTAMATE-1-SEMIALDEHYDE AMINOMUTASE (AMINOTRANSFERASE) REDUCED WITH CYANOBOROHYDRATE
Descriptor:GLUTAMATE SEMIALDEHYDE AMINOTRANSFERASE, PYRIDOXAL-5'-PHOSPHATE
Authors:Hennig, M., Jansonius, J.N.
Deposit date:1997-02-26
Release date:1998-03-04
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Crystal structure of glutamate-1-semialdehyde aminomutase: an alpha2-dimeric vitamin B6-dependent enzyme with asymmetry in structure and active site reactivity.
Proc.Natl.Acad.Sci.USA, 94, 1997
1CBK
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7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE FROM HAEMOPHILUS INFLUENZAE
Descriptor:PROTEIN (7,8-DIHYDRO-6-HYDROXYMETHYLPTERIN-PYROPHOSPHOKINASE), SULFATE ION, 7,8-DIHYDRO-7,7-DIMETHYL-6-HYDROXYPTERIN
Authors:Hennig, M., D'Arcy, A., Dale, G., Oefner, C.
Deposit date:1999-02-26
Release date:2000-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.02 Å)
Cite:The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae.
J.Mol.Biol., 287, 1999
1DHN
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1.65 ANGSTROM RESOLUTION STRUCTURE OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS
Descriptor:7,8-DIHYDRONEOPTERIN ALDOLASE
Authors:Hennig, M., D'Arcy, A., Hampele, I.C., Page, M.G.P., Oefner, C.H., Dale, G.
Deposit date:1998-03-31
Release date:1999-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus.
Nat.Struct.Biol., 5, 1998
1IGS
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INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS AT 2.0 A RESOLUTION
Descriptor:INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE, PHOSPHATE ION
Authors:Hennig, M., Darimont, B., Kirschner, K., Jansonius, J.N.
Deposit date:1995-08-11
Release date:1996-07-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:2.0 A structure of indole-3-glycerol phosphate synthase from the hyperthermophile Sulfolobus solfataricus: possible determinants of protein stability.
Structure, 3, 1995
1LBF
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CRYSTAL STRUCTURE OF INDOLE-3-GLYCEROL PHOSPHATE SYNTASE (IGPS)WITH REDUCED 1-(O-CABOXYPHENYLAMINO)-1-DEOXYRIBULOSE 5-PHOSPHATE (RCDRP)
Descriptor:INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE, 1-(O-CARBOXY-PHENYLAMINO)-1-DEOXY-D-RIBULOSE-5-PHOSPHATE
Authors:Hennig, M., Darimont, B., Kirschner, K., Jansonius, J.N.
Deposit date:2002-04-03
Release date:2002-06-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.05 Å)
Cite:The catalytic mechanism of indole-3-glycerol phosphate synthase: crystal structures of complexes of the enzyme from Sulfolobus solfataricus with substrate analogue, substrate, and product.
J.Mol.Biol., 319, 2002
1LBL
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CRYSTAL STRUCTURE OF INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE (IGPS) IN COMPLEX WITH 1-(O-CARBOXYPHENYLAMINO)-1-DEOXYRIBULOSE 5'-PHOSPHATE (CDRP)
Descriptor:indole-3-glycerol phosphate synthase, 1-(O-CARBOXY-PHENYLAMINO)-1-DEOXY-D-RIBULOSE-5-PHOSPHATE
Authors:Hennig, M., Darimont, B.D., Kirschner, K., Jansonius, J.N.
Deposit date:2002-04-04
Release date:2002-09-18
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:The catalytic mechanism of indole-3-glycerol phosphate synthase: Crystal structures of complexes of the enzyme from Sulfolobus solfataricus with the substrate analogue, substrate, and product
J.Mol.Biol., 319, 2002
2DHN
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COMPLEX OF 7,8-DIHYDRONEOPTERIN ALDOLASE FROM STAPHYLOCOCCUS AUREUS WITH 6-HYDROXYMETHYL-7,8-DIHYDROPTERIN AT 2.2 A RESOLUTION
Descriptor:7,8-DIHYDRONEOPTERIN ALDOLASE, 2-AMINO-6-HYDROXYMETHYL-7,8-DIHYDRO-3H-PTERIDIN-4-ONE
Authors:Hennig, M., D'Arcy, A., Hampele, I.C., Page, M.G.P., Oefner, C.H., Dale, G.
Deposit date:1998-03-31
Release date:1999-04-20
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Crystal structure and reaction mechanism of 7,8-dihydroneopterin aldolase from Staphylococcus aureus.
Nat.Struct.Biol., 5, 1998
1LBM
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CRYSTAL STRUCTURE OF PHOSPHORIBOSYL ANTHRANILATE ISOMERASE (PRAI) IN COMPLEX WITH REDUCED 1-(O-CARBOXYPHENYLAMINO)-1-DEOXYRIBULOSE 5-PHOSPHATE (RCDRP)
Descriptor:PHOSPHORIBOSYL ANTHRANILATE ISOMERASE, 1-(O-CARBOXY-PHENYLAMINO)-1-DEOXY-D-RIBULOSE-5-PHOSPHATE
Authors:Hennig, M., Sterner, R., Kirschner, K.
Deposit date:2002-04-04
Release date:2002-12-18
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Two (betaalpha)(8)-barrel enzymes of histidine and tryptophan biosynthesis have similar reaction mechanisms and common strategies for protecting their labile substrates
Biochemistry, 41, 2002
1NU6
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CRYSTAL STRUCTURE OF HUMAN DIPEPTIDYL PEPTIDASE IV (DPP-IV)
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, MERCURY (II) ION, ...
Authors:Hennig, M., Stihle, M., Thoma, R., Ruf, A.
Deposit date:2003-01-31
Release date:2003-08-26
Last modified:2014-04-23
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural Basis of Proline-Specific Exopeptidase Activity as Observed in Human Dipeptidyl Peptidase-IV.
Structure, 11, 2003
1RWQ
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HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH 5-AMINOMETHYL-6-(2,4-DICHLORO-PHENYL)-2-(3,5-DIMETHOXY-PHENYL)-PYRIMIDIN-4-YLAMINE
Descriptor:Dipeptidyl peptidase IV, N-ACETYL-D-GLUCOSAMINE, 5-(AMINOMETHYL)-6-(2,4-DICHLOROPHENYL)-2-(3,5-DIMETHOXYPHENYL)PYRIMIDIN-4-AMINE
Authors:Hennig, M., Thoma, R., Stihle, M.
Deposit date:2003-12-17
Release date:2004-12-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents
Bioorg.Med.Chem.Lett., 14, 2004
2BIT
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CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN D AT 1.7 A RESOLUTION
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE
Authors:Hennig, M., Thoma, R., Stihle, M., Schlatter, D.
Deposit date:2005-01-26
Release date:2005-01-26
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Crystal Engineering Yields Crystals of Cyclophilin D Diffracting to 1.7 A Resolution
Acta Crystallogr.,Sect.D, 61, 2005
2BIU
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CRYSTAL STRUCTURE OF HUMAN CYCLOPHILIN D AT 1.7 A RESOLUTION, DMSO COMPLEX
Descriptor:PEPTIDYL-PROLYL CIS-TRANS ISOMERASE, DIMETHYL SULFOXIDE
Authors:Hennig, M., Thoma, R., Stihle, M., Schlatter, D.
Deposit date:2005-01-26
Release date:2005-01-26
Last modified:2018-06-13
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Crystal Engineering Yields Crystals of Cyclophilin D Diffracting to 1.7 A Resolution
Acta Crystallogr.,Sect.D, 61, 2005
2JID
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HUMAN DIPEPTIDYL PEPTIDASE IV IN COMPLEX WITH 1-(3,4-DIMETHOXY-PHENYL) -3-M-TOLYL-PIPERIDINE-4-YLAMINE
Descriptor:DIPEPTIDYL PEPTIDASE 4, N-ACETYL-D-GLUCOSAMINE, (3R,4S)-1-(3,4-DIMETHOXYPHENYL)-3-(3-METHYLPHENYL)PIPERIDIN-4-AMINE
Authors:Hennig, M., Stihle, M., Luebbers, T., Thoma, R.
Deposit date:2007-02-28
Release date:2008-05-27
Last modified:2012-08-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:1,3-Disubstituted 4-Aminopiperidines as Useful Tools in the Optimization of the 2-Aminobenzo[A]Quinolizine Dipeptidyl Peptidase Iv Inhibitors.
Bioorg.Med.Chem.Lett., 17, 2007
3KWF
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HUMAN DPP-IV WITH CARMEGLIPTIN (S)-1-((2S,3S,11BS)-2-AMINO-9,10-DIMETHOXY-1,3,4,6,7,11B-HEXAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLIN-3-YL)-4-FLUOROMETHYL-PYRROLIDIN-2-ONE
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, (4S)-1-[(2S,3S,11bS)-2-amino-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-3-yl]-4-(fluoromethyl)pyrrolidin-2-one
Authors:Hennig, M., Stihle, M., Thoma, R.
Deposit date:2009-12-01
Release date:2010-01-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Bioorg.Med.Chem.Lett., 20, 2010
3KWJ
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STRUCUTRE OF HUMAN DPP-IV WITH (2S,3S,11BS)-3-(3-FLUOROMETHYL-PHENYL)-9,10-DIMETHOXY-1,3,4,6,7,11B-HEXAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLIN-2-YLAMINE
Descriptor:Dipeptidyl peptidase 4 soluble form, N-ACETYL-D-GLUCOSAMINE, (2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Authors:Hennig, M., Stihle, M., Thoma, R.
Deposit date:2009-12-01
Release date:2010-09-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors.
Bioorg.Med.Chem.Lett., 20, 2010
3OC0
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STRUCTURE OF HUMAN DPP-IV WITH HTS HIT (2S,3S,11BS)-3-BUTYL-9,10-DIMETHOXY-1,3,4,6,7,11B-HEXAHYDRO-2H-PYRIDO[2,1-A]ISOQUINOLIN-2-YLAMINE
Descriptor:Dipeptidyl peptidase 4, N-ACETYL-D-GLUCOSAMINE, (2S,3R,11bR)-3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine
Authors:Hennig, M., Stihle, M., Thoma, R.
Deposit date:2010-08-09
Release date:2010-08-25
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.7 Å)
Cite:Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Bioorg.Med.Chem.Lett., 20, 2010
1JUK
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INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS IN A TRIGONAL CRYSTAL FORM
Descriptor:INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE, SULFATE ION
Authors:Knoechel, T.R., Hennig, M., Merz, A., Darimont, B., Kirschner, K., Jansonius, J.N.
Deposit date:1996-05-03
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of indole-3-glycerol phosphate synthase from the hyperthermophilic archaeon Sulfolobus solfataricus in three different crystal forms: effects of ionic strength.
J.Mol.Biol., 262, 1996
1JUL
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INDOLE-3-GLYCEROLPHOSPHATE SYNTHASE FROM SULFOLOBUS SOLFATARICUS IN A SECOND ORTHORHOMBIC CRYSTAL FORM
Descriptor:INDOLE-3-GLYCEROL PHOSPHATE SYNTHASE, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID
Authors:Knoechel, T.R., Hennig, M., Merz, A., Darimont, B., Kirschner, K., Jansonius, J.N.
Deposit date:1996-05-03
Release date:1997-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:The crystal structure of indole-3-glycerol phosphate synthase from the hyperthermophilic archaeon Sulfolobus solfataricus in three different crystal forms: effects of ionic strength.
J.Mol.Biol., 262, 1996
2KMJ
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HIGH RESOLUTION NMR SOLUTION STRUCTURE OF A COMPLEX OF HIV-2 TAR RNA AND A SYNTHETIC TRIPEPTIDE IN A 1:2 STOICHIOMETRY
Descriptor:RNA (28-MER), Pyrimidinylpeptide
Authors:Ferner, J., Suhartono, M., Breitung, S., Jonker, H.R.A., Hennig, M., Woehnert, J., Goebel, M., Schwalbe, H.
Deposit date:2009-07-30
Release date:2009-08-18
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structures of HIV TAR RNA-ligand complexes reveal higher binding stoichiometries.
Chembiochem, 10, 2009