3OC0
Structure of human DPP-IV with HTS hit (2S,3S,11bS)-3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine
Replaces: 3KWHSummary for 3OC0
Entry DOI | 10.2210/pdb3oc0/pdb |
Related | 3KWF 3KWH 3KWJ |
Descriptor | Dipeptidyl peptidase 4, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2S,3R,11bR)-3-butyl-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine, ... (4 entities in total) |
Functional Keywords | diabetes type ii, aminopeptidase, cell membrane, disulfide bond, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 171331.81 |
Authors | Hennig, M.,Stihle, M.,Thoma, R. (deposition date: 2010-08-09, release date: 2010-08-25, Last modification date: 2020-07-29) |
Primary citation | Mattei, P.,Boehringer, M.,Di Giorgio, P.,Fischer, H.,Hennig, M.,Huwyler, J.,Kocer, B.,Kuhn, B.,Loeffler, B.M.,Macdonald, A.,Narquizian, R.,Rauber, E.,Sebokova, E.,Sprecher, U. Discovery of carmegliptin: A potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes. Bioorg.Med.Chem.Lett., 20:1109-1113, 2010 Cited by PubMed: 20031405DOI: 10.1016/j.bmcl.2009.12.024 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.7 Å) |
Structure validation
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