Author results

1SOC
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NMR STUDY OF THE BACKBONE CONFORMATIONAL EQUILIBRIA OF SANDOSTATIN, MINIMIZED AVERAGE BETA-SHEET STRUCTURE
Descriptor:SANDOSTATIN
Authors:Melacini, G., Zhu, Q., Goodman, M.
Deposit date:1996-11-26
Release date:1997-04-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Multiconformational NMR analysis of sandostatin (octreotide): equilibrium between beta-sheet and partially helical structures.
Biochemistry, 36, 1997
2SOC
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NMR STUDY OF THE BACKBONE CONFORMATIONAL EQUILIBRIA OF SANDOSTATIN, TWO REPRESENTATIVE MINIMUM ENERGY PARTIALLY HELICAL STRUCTURES
Descriptor:SANDOSTATIN
Authors:Melacini, G., Zhu, Q., Goodman, M.
Deposit date:1996-11-26
Release date:1997-04-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Multiconformational NMR analysis of sandostatin (octreotide): equilibrium between beta-sheet and partially helical structures.
Biochemistry, 36, 1997
1AXT
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IMMUNE VERSUS NATURAL SELECTION: ANTIBODY ALDOLASES WITH THE RATES OF NATURAL ENZYMES
Descriptor:IMMUNOGLOBULIN IGG2A
Authors:Heine, A., Wilson, I.A.
Deposit date:1997-10-20
Release date:1998-10-28
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.15 Å)
Cite:Immune versus natural selection: antibody aldolases with enzymic rates but broader scope.
Science, 278, 1997
1A3L
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CATALYSIS OF A DISFAVORED REACTION: AN ANTIBODY EXO DIELS-ALDERASE-TSA-INHIBITOR COMPLEX AT 1.95 A RESOLUTION
Descriptor:IMMUNOGLOBULIN FAB 13G5 (LIGHT CHAIN), IMMUNOGLOBULIN FAB 13G5 (HEAVY CHAIN), 1-CARBOXY-1'-[(DIMETHYLAMINO)-CARBONYL]FERROCENE
Authors:Heine, A., Wilson, I.A.
Deposit date:1998-01-22
Release date:1999-02-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:An antibody exo Diels-Alderase inhibitor complex at 1.95 angstrom resolution.
Science, 279, 1998
15C8
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CATALYTIC ANTIBODY 5C8, FREE FAB
Descriptor:IGG 5C8 FAB (LIGHT CHAIN), IGG 5C8 FAB (HEAVY CHAIN)
Authors:Gruber, K., Wilson, I.A.
Deposit date:1998-03-18
Release date:1999-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Ligand-Induced Conformational Changes in a Catalytic Antibody: Comparison of the Bound and Unbound Structure of Fab 5C8
To be Published
25C8
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CATALYTIC ANTIBODY 5C8, FAB-HAPTEN COMPLEX
Descriptor:IGG 5C8, N-METHYL-N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM ION
Authors:Gruber, K., Wilson, I.A.
Deposit date:1998-03-18
Release date:1999-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for antibody catalysis of a disfavored ring closure reaction.
Biochemistry, 38, 1999
35C8
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CATALYTIC ANTIBODY 5C8, FAB-INHIBITOR COMPLEX
Descriptor:IGG 5C8, N-(PARA-GLUTARAMIDOPHENYL-ETHYL)-PIPERIDINIUM-N-OXIDE
Authors:Gruber, K., Wilson, I.A.
Deposit date:1998-03-18
Release date:1999-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural basis for antibody catalysis of a disfavored ring closure reaction.
Biochemistry, 38, 1999
1D5T
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GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, ALPHA-ISOFORM
Descriptor:GUANINE NUCLEOTIDE DISSOCIATION INHIBITOR, SULFATE ION
Authors:Peng, L., Zeng, K., Heine, A., Moyer, B., Greasley, S.E., Kuhn, P., Balch, W.E., Wilson, I.A.
Deposit date:1999-10-11
Release date:2000-10-25
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.04 Å)
Cite:A new functional domain of guanine nucleotide dissociation inhibitor (alpha-GDI) involved in Rab recycling.
Traffic, 1, 2000
1I7Z
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ANTIBODY GNC92H2 BOUND TO LIGAND
Descriptor:CHIMERA OF IG KAPPA CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION, CHIMERA OF IG GAMMA-1 CHAIN: HUMAN CONSTANT REGION AND MOUSE VARIABLE REGION, COCAINE
Authors:Larsen, N.A., Wilson, I.A.
Deposit date:2001-03-12
Release date:2001-08-08
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Crystal structure of a cocaine-binding antibody.
J.Mol.Biol., 311, 2001
1JCJ
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OBSERVATION OF COVALENT INTERMEDIATES IN AN ENZYME MECHANISM AT ATOMIC RESOLUTION
Descriptor:DEOXYRIBOSE-PHOSPHATE ALDOLASE, 1-HYDROXY-PENTANE-3,4-DIOL-5-PHOSPHATE
Authors:Heine, A., DeSantis, G., Luz, J.G., Mitchell, M., Wong, C.-H., Wilson, I.A.
Deposit date:2001-06-09
Release date:2001-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.1 Å)
Cite:Observation of covalent intermediates in an enzyme mechanism at atomic resolution.
Science, 294, 2001
1JCL
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OBSERVATION OF COVALENT INTERMEDIATES IN AN ENZYME MECHANISM AT ATOMIC RESOLUTION
Descriptor:DEOXYRIBOSE-PHOSPHATE ALDOLASE, 1-HYDROXY-PENTANE-3,4-DIOL-5-PHOSPHATE
Authors:Heine, A., DeSantis, G., Luz, J.G., Mitchell, M., Wong, C.-H., Wilson, I.A.
Deposit date:2001-06-09
Release date:2001-10-31
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.05 Å)
Cite:Observation of covalent intermediates in an enzyme mechanism at atomic resolution.
Science, 294, 2001
1JGU
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STRUCTURAL BASIS FOR DISFAVORED ELIMINATION REACTION IN CATALYTIC ANTIBODY 1D4
Descriptor:Antibody Light Chain, Antibody Heavy Chain, HYDROXIDE ION, ...
Authors:Larsen, N.A., Heine, A., Crane, L., Cravatt, B.F., Lerner, R.A., Wilson, I.A.
Deposit date:2001-06-26
Release date:2001-12-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structural basis for a disfavored elimination reaction in catalytic antibody 1D4.
J.Mol.Biol., 314, 2001
1JGV
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STRUCTURAL BASIS FOR DISFAVORED ELIMINATION REACTION IN CATALYTIC ANTIBODY 1D4
Descriptor:Antibody Light Chain, Antibody Heavy Chain
Authors:Larsen, N.A., Heine, A., Crane, L., Cravatt, B.F., Lerner, R.A., Wilson, I.A.
Deposit date:2001-06-26
Release date:2001-12-05
Last modified:2018-01-31
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Structural basis for a disfavored elimination reaction in catalytic antibody 1D4.
J.Mol.Biol., 314, 2001
1NCW
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CATIONIC CYCLIZATION ANTIBODY 4C6 IN COMPLEX WITH BENZOIC ACID
Descriptor:IMMUNOGLOBULIN IGG2A, BENZOIC ACID, GLYCEROL
Authors:Zhu, X., Wilson, I.A.
Deposit date:2002-12-05
Release date:2003-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.3 Å)
Cite:Structural Basis for Antibody Catalysis of a Cationic Cyclization Reaction
J.Mol.Biol., 329, 2003
1ND0
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CATIONIC CYCLIZATION ANTIBODY 4C6 COMPLEX WITH TRANSITION STATE ANALOG
Descriptor:IMMUNOGLOBULIN IGG2A, (1s,4s)-4-[dimethyl(phenyl)silyl]-1-methylpiperidine 1-oxide, SULFATE ION
Authors:Zhu, X., Wilson, I.A.
Deposit date:2002-12-05
Release date:2003-05-13
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.45 Å)
Cite:Structural Basis for Antibody Catalysis of a Cationic Cyclization Reaction
J.Mol.Biol., 329, 2003
1NYK
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CRYSTAL STRUCTURE OF THE RIESKE PROTEIN FROM THERMUS THERMOPHILUS
Descriptor:Rieske iron-sulfur protein, MAGNESIUM ION, FE2/S2 (INORGANIC) CLUSTER
Authors:Hunsicker-Wang, L.M., Heine, A., Chen, Y., Luna, E.P., Todaro, T., Zhang, Y.M., Williams, P.A., McRee, D.E., Hirst, J., Stout, C.D., Fee, J.A.
Deposit date:2003-02-12
Release date:2003-06-24
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.31 Å)
Cite:High resolution structure of the soluble, respiratory-type Rieske protein from Thermus thermophilus: Analysis and Comparison
Biochemistry, 42, 2003
1MEX
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ANTIBODY CATALYSIS OF A BIMOLECULAR CYCLOADDITION REACTION
Descriptor:Fab 29G12 light chain, Fab 29G12 heavy chain, 4-(2-DIMETHYLCARBAMOYL-PHENYLCARBAMOYLOXYMETHYL)-BENZOIC ACID
Authors:Heine, A., Wilson, I.A.
Deposit date:2002-08-08
Release date:2003-09-02
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.25 Å)
Cite:Antibody Catalysis of a Bimolecular Cycloaddition Reaction
To be Published
1O58
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CRYSTAL STRUCTURE OF O-ACETYLSERINE SULFHYDRYLASE (TM0665) FROM THERMOTOGA MARITIMA AT 1.80 A RESOLUTION
Descriptor:O-acetylserine sulfhydrylase, PHOSPHATE ION
Authors:Joint Center for Structural Genomics (JCSG)
Deposit date:2003-08-20
Release date:2003-09-02
Last modified:2018-07-18
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Crystal structure of O-acetylserine sulfhydrylase (TM0665) from Thermotoga maritima at 1.8 A resolution
Proteins, 56, 2004
1OZM
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Y106F MUTANT OF Z. MOBILIS TGT
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION
Authors:Brenk, R., Stubbs, M.T., Heine, A., Reuter, K., Klebe, G.
Deposit date:2003-04-09
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design
Chembiochem, 4, 2003
1OZQ
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CRYSTAL STRUCTURE OF THE MUTATED TRNA-GUANINE TRANSGLYCOSYLASE (TGT)Y106F COMPLEXED WITH PREQ1
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, 7-DEAZA-7-AMINOMETHYL-GUANINE
Authors:Brenk, R., Stubbs, M.T., Heine, A., Reuter, K., Klebe, G.
Deposit date:2003-04-09
Release date:2003-09-30
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design
Chembiochem, 4, 2003
1P0B
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CRYSTAL STRUCTURE OF TRNA-GUANINE TRANSGLYCOSYLASE (TGT) FROM ZYMOMONAS MOBILIS COMPLEXED WITH ARCHAEOSINE PRECURSOR, PREQ0
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, 2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDINE-5-CARBONITRILE
Authors:Brenk, R., Stubbs, M.T., Heine, A., Reuter, K., Klebe, G.
Deposit date:2003-04-10
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design
Chembiochem, 4, 2003
1P0D
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CRYSTAL STRUCTURE OF ZYMOMONAS MOBILIS TRNA-GUANINE TRANSGLYCOSYLASE (TGT) CRYSTALLISED AT PH 5.5
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION
Authors:Brenk, R., Stubbs, M.T., Heine, A., Reuter, K., Klebe, G.
Deposit date:2003-04-10
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design
Chembiochem, 4, 2003
1P0E
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CRYSTAL STRUCTURE OF ZYMOMONAS MOBILIS TRNA-GUANINE TRANSGLYCOSYLASE (TGT) COCRYSTALLISED WITH PREQ1 AT PH 5.5
Descriptor:Queuine tRNA-ribosyltransferase, ZINC ION, 7-DEAZA-7-AMINOMETHYL-GUANINE
Authors:Brenk, R., Stubbs, M.T., Heine, A., Reuter, K., Klebe, G.
Deposit date:2003-04-10
Release date:2003-09-30
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Flexible adaptations in the structure of the tRNA-modifying enzyme tRNA-guanine transglycosylase and their implications for substrate selectivity, reaction mechanism and structure-based drug design
Chembiochem, 4, 2003
1NJ9
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COCAINE HYDROLYTIC ANTIBODY 15A10
Descriptor:immunoglobulin variable chain, immunoglobulin heavy chain, SODIUM ION
Authors:Larsen, N.A., de Prada, P., Deng, S.X., Zhu, X., Landry, D.W., Wilson, I.A.
Deposit date:2002-12-30
Release date:2004-02-17
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2.35 Å)
Cite:Crystallographic and biochemical analysis of cocaine-degrading antibody 15A10.
Biochemistry, 43, 2004
1RU9
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CRYSTAL STRUCTURE (A) OF U.V.-IRRADIATED CATIONIC CYCLIZATION ANTIBODY 4C6 FAB AT PH 4.6 WITH A DATA SET COLLECTED IN-HOUSE.
Descriptor:immunoglobulin igg2a, light chain, heavy chain, ...
Authors:Zhu, X., Wentworth Jr., P., Wentworth, A.D., Eschenmoser, A., Lerner, R.A., Wilson, I.A.
Deposit date:2003-12-11
Release date:2004-03-02
Last modified:2013-06-05
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Probing the antibody-catalyzed water-oxidation pathway at atomic resolution.
Proc.Natl.Acad.Sci.USA, 110, 2004