6QCK

17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with FB262

Summary for 6QCK

• Entry DOI: 10.2210/pdb6qck/pdb
• Descriptor: 17-beta-hydroxysteroid dehydrogenase 14, DIMETHYL SULFOXIDE, 2-[2-(1,3-benzodioxol-2-yl)ethyl]benzoic acid, ... (7 entities in total)
• Functional Keywords: fragments, soaking, 17b-hsd14, oxidoreductase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 29897.72

Authors

Bertoletti, N.,Marchais-Oberwinkler, S.,Heine, A.,Klebe, G. (deposition date: 2018-12-28, release date: 2020-01-29, Last modification date: 2024-01-24)

• Primary citation: Badran, M.J.,Bertoletti, N.,Keils, A.,Heine, A.,Klebe, G.,Marchais-Oberwinkler, S.; Mutational and structural studies uncover crucial amino acids determining activity and stability of 17 beta-HSD14.; J.Steroid Biochem.Mol.Biol., 189:135-144, 2019; PubMed: 30836176; DOI: 10.1016/j.jsbmb.2019.02.009

Experimental method

X-RAY DIFFRACTION (1.68 Å)