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SummaryStructural detailsExperimental detailsFunctional detailsSequence NeighborHistoryDownloads

6QCK

17beta-hydroxysteroid dehydrogenase 14 variant T205 in complex with FB262

Functional Information from GO Data
ChainGOidnamespacecontents
A0004303molecular_functionestradiol 17-beta-dehydrogenase [NAD(P)+] activity
A0005515molecular_functionprotein binding
A0005737cellular_componentcytoplasm
A0005829cellular_componentcytosol
A0006004biological_processfucose metabolic process
A0006629biological_processlipid metabolic process
A0008202biological_processsteroid metabolic process
A0016491molecular_functionoxidoreductase activity
A0042355biological_processL-fucose catabolic process
A0042802molecular_functionidentical protein binding
A0047834molecular_functionD-threo-aldose 1-dehydrogenase activity
Functional Information from PROSITE/UniProt
site_idPS00061
Number of Residues29
DetailsADH_SHORT Short-chain dehydrogenases/reductases family signature. SlvgaigqaqAvpYVATKGAVtAMTkALA
ChainResidueDetails
ASER141-ALA169
Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues1
DetailsActive site: {"description":"Proton acceptor","evidences":[{"source":"PROSITE-ProRule","id":"PRU10001","evidenceCode":"ECO:0000255"}]}
ChainResidueDetails
site_idSWS_FT_FI2
Number of Residues8
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27362750","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27933965","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29859505","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30836176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EN4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FFB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6G4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6HNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZR6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZRA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZT2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI3
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27362750","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5O6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZRA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZT2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI4
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PDB","id":"5EN4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FFB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6G4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6HNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZR6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZRA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZT2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI5
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27362750","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27933965","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29859505","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30836176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EN4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FFB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6H0M","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6HNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZRA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZT2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails
site_idSWS_FT_FI6
Number of Residues1
DetailsBinding site: {"evidences":[{"source":"PubMed","id":"27362750","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"27933965","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"29859505","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"30836176","evidenceCode":"ECO:0000269"},{"source":"PDB","id":"5EN4","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5HS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5ICM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JS6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5JSF","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7T","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7W","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5L7Y","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O42","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O43","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6O","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6X","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O6Z","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O72","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"5O7C","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6EMM","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6FFB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6G4L","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GBT","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTB","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6GTU","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6HNO","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6QCK","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDE","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZDI","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZR6","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZRA","evidenceCode":"ECO:0007744"},{"source":"PDB","id":"6ZT2","evidenceCode":"ECO:0007744"}]}
ChainResidueDetails

239149

PDB entries from 2025-07-23

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