2IKG

Aldose reductase complexed with nitrophenyl-oxadiazol type inhibitor at 1.43 A

Summary for 2IKG

Entry DOI	10.2210/pdb2ikg/pdb
Related	1US0 2IKH 2IKI 2IKJ
Descriptor	Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACID, ... (4 entities in total)
Functional Keywords	tim barrel, inhibitor complex, aldose reductase, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	36918.98
Authors	Steuber, H.,Koch, C.,Heine, A.,Klebe, G. (deposition date: 2006-10-02, release date: 2007-05-01, Last modification date: 2023-10-25)
Primary citation	Steuber, H.,Heine, A.,Klebe, G. Structural and Thermodynamic Study on Aldose Reductase: Nitro-substituted Inhibitors with Strong Enthalpic Binding Contribution J.Mol.Biol., 368:618-638, 2007 Cited by PubMed: 17368668 DOI: 10.1016/j.jmb.2006.12.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.43 Å)

Structure validation