2IKG
Aldose reductase complexed with nitrophenyl-oxadiazol type inhibitor at 1.43 A
Summary for 2IKG
Entry DOI | 10.2210/pdb2ikg/pdb |
Related | 1US0 2IKH 2IKI 2IKJ |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-[3-(3-NITROPHENYL)-1,2,4-OXADIAZOL-5-YL]BUTANOIC ACID, ... (4 entities in total) |
Functional Keywords | tim barrel, inhibitor complex, aldose reductase, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 36918.98 |
Authors | Steuber, H.,Koch, C.,Heine, A.,Klebe, G. (deposition date: 2006-10-02, release date: 2007-05-01, Last modification date: 2023-10-25) |
Primary citation | Steuber, H.,Heine, A.,Klebe, G. Structural and Thermodynamic Study on Aldose Reductase: Nitro-substituted Inhibitors with Strong Enthalpic Binding Contribution J.Mol.Biol., 368:618-638, 2007 Cited by PubMed: 17368668DOI: 10.1016/j.jmb.2006.12.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.43 Å) |
Structure validation
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