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2IQD
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE COMPLEXED WITH LIPOIC ACID
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, LIPOIC ACID
Authors:Harrison, D.H.T., Carlson, E., Pape, E., Brownlee, J.M.
Deposit date:2006-10-13
Release date:2006-11-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.
Bioorg.Chem., 34, 2006
1T47
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STRUCTURE OF FE2-HPPD BOUND TO NTBC
Descriptor:4-hydroxyphenylpyruvate dioxygenase, FE (II) ION, 2-{HYDROXY[2-NITRO-4-(TRIFLUOROMETHYL)PHENYL]METHYLENE}CYCLOHEXANE-1,3-DIONE
Authors:Brownlee, J., Johnson-Winters, K., Harrison, D.H.T., Moran, G.R.
Deposit date:2004-04-28
Release date:2004-06-15
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structure of the Ferrous Form of (4-Hydroxyphenyl)pyruvate Dioxygenase from Streptomyces avermitilis in Complex with the Therapeutic Herbicide, NTBC
Biochemistry, 43, 2004
1XGD
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APO R268A HUMAN ALDOSE REDUCTASE
Descriptor:Aldose reductase
Authors:Brownlee, J.M., Bohren, K.M., Milne, A.C., Gabbay, K.H., Harrison, D.H.T.
Deposit date:2004-09-16
Release date:2005-03-29
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:The structure of Apo R268A human aldose reductase: Hinges and latches that control the kinetic mechanism
Biochim.Biophys.Acta, 1748, 2005
1XPK
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS HMG-COA SYNTHASE WITH HMG-COA AND WITH ACETOACETYL-COA AND ACETYLATED CYSTEINE
Descriptor:3-hydroxy-3-methylglutaryl CoA synthase, SULFATE ION, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, ...
Authors:Theisen, M.J., Misra, I., Saadat, D., Campobasso, N., Miziorko, H.M., Harrison, D.H.T.
Deposit date:2004-10-08
Release date:2004-11-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"
Proc.Natl.Acad.Sci.USA, 47, 2004
1XPL
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS HMG-COA SYNTHASE WITH ACETOACETYL-COA AND ACETYLATED CYSTEINE
Descriptor:3-hydroxy-3-methylglutaryl CoA synthase, SULFATE ION, ACETOACETYL-COENZYME A
Authors:Theisen, M.J., Misra, I., Saadat, D., Campobasso, N., Miziorko, H.M., Harrison, D.H.T.
Deposit date:2004-10-08
Release date:2004-11-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (2 Å)
Cite:3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"
Proc.Natl.Acad.Sci.USA, 47, 2004
1XPM
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CRYSTAL STRUCTURE OF STAPHYLOCOCCUS AUREUS HMG-COA SYNTHASE WITH HMG-COA AND ACETOACETYL-COA AND ACETYLATED CYSTEINE
Descriptor:3-hydroxy-3-methylglutaryl CoA synthase, SULFATE ION, 3-HYDROXY-3-METHYLGLUTARYL-COENZYME A, ...
Authors:Theisen, M.J., Misra, I., Saadat, D., Campobasso, N., Miziorko, H.M., Harrison, D.H.T.
Deposit date:2004-10-08
Release date:2004-11-02
Last modified:2017-10-11
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:3-hydroxy-3-methylglutaryl-CoA synthase intermediate complex observed in "real-time"
Proc.Natl.Acad.Sci.USA, 47, 2004
1A7J
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PHOSPHORIBULOKINASE FROM RHODOBACTER SPHEROIDES
Descriptor:PHOSPHORIBULOKINASE, SULFATE ION
Authors:Harrison, D.H.T., Runquist, J., Holub, A., Miziorko, H.
Deposit date:1998-03-16
Release date:1998-06-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:The crystal structure of phosphoribulokinase from Rhodobacter sphaeroides reveals a fold similar to that of adenylate kinase.
Biochemistry, 37, 1998
1AZ1
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ALRESTATIN BOUND TO C298A/W219Y MUTANT HUMAN ALDOSE REDUCTASE
Descriptor:ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ALRESTATIN
Authors:Harrison, D.H.T., Bohren, K.M., Petsko, G.A., Ringe, D., Gabbay, K.H.
Deposit date:1997-11-24
Release date:1998-03-18
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:The alrestatin double-decker: binding of two inhibitor molecules to human aldose reductase reveals a new specificity determinant.
Biochemistry, 36, 1997
2INE
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE COMPLEXED WITH PHENYLACETIC ACID
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-PHENYLACETIC ACID
Authors:Harrison, D.H.T., Milne, A., Brownlee, J.M.
Deposit date:2006-10-06
Release date:2006-11-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.
Bioorg.Chem., 34, 2006
2INZ
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE COMPLEXED WITH 2-HYDROXYPHENYLACETIC ACID
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2-HYDROXYPHENYL)ACETIC ACID
Authors:Harrison, D.H.T., Pape, E., Carlson, E., Brownlee, J.M.
Deposit date:2006-10-09
Release date:2006-11-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.
Bioorg.Chem., 34, 2006
2IPW
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CRYSTAL STRUCTURE OF C298A W219Y ALDOSE REDUCTASE COMPLEXED WITH DICHLOROPHENYLACETIC ACID
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2,6-DICHLOROPHENYL)ACETIC ACID
Authors:Harrison, D.H.T., Pape, E., Brownlee, J.M.
Deposit date:2006-10-12
Release date:2006-11-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.
Bioorg.Chem., 34, 2006
2IQ0
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE COMPLEXED WITH HEXANOIC ACID
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, HEXANOIC ACID
Authors:Harrison, D.H.T., Brownlee, J.M.
Deposit date:2006-10-12
Release date:2006-11-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.
Bioorg.Chem., 34, 2006
2IS7
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CRYSTAL STRUCTURE OF ALDOSE REDUCTASE COMPLEXED WITH DICHLOROPHENYLACETIC ACID
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2,6-DICHLOROPHENYL)ACETIC ACID
Authors:Harrison, D.H.T., Milne, A., Brownlee, J.M.
Deposit date:2006-10-16
Release date:2006-11-21
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.
Bioorg.Chem., 34, 2006
2ISF
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CRYSTAL STRUCTURE OF C298A W219Y ALDOSE REDUCTASE COMPLEXED WITH PHENYLACETIC ACID
Descriptor:Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-PHENYLACETIC ACID
Authors:Harrison, D.H.T., Pape, E., Brownlee, J.M.
Deposit date:2006-10-17
Release date:2006-11-28
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes.
Bioorg.Chem., 34, 2006
1B93
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METHYLGLYOXAL SYNTHASE FROM ESCHERICHIA COLI
Descriptor:PROTEIN (METHYLGLYOXAL SYNTHASE), FORMIC ACID, PHOSPHATE ION
Authors:Saadat, D., Harrison, D.H.T.
Deposit date:1999-02-23
Release date:1999-03-16
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:The crystal structure of methylglyoxal synthase from Escherichia coli.
Structure Fold.Des., 7, 1999
1EGH
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STRUCTURE OF METHYLGLYOXAL SYNTHASE COMPLEXED WITH THE COMPETITIVE INHIBITOR 2-PHOSPHOGLYCOLATE
Descriptor:METHYLGLYOXAL SYNTHASE, 2-PHOSPHOGLYCOLIC ACID
Authors:Saadat, D., Harrison, D.H.T.
Deposit date:2000-02-15
Release date:2000-03-01
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mirroring perfection: the structure of methylglyoxal synthase complexed with the competitive inhibitor 2-phosphoglycolate.
Biochemistry, 39, 2000
1IK4
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X-RAY STRUCTURE OF METHYLGLYOXAL SYNTHASE FROM E. COLI COMPLEXED WITH PHOSPHOGLYCOLOHYDROXAMIC ACID
Descriptor:METHYLGLYOXAL SYNTHASE, PHOSPHOGLYCOLOHYDROXAMIC ACID
Authors:Marks, G.T., Harris, T.K., Massiah, M.A., Mildvan, A.S., Harrison, D.H.T.
Deposit date:2001-05-02
Release date:2001-09-26
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2 Å)
Cite:Mechanistic implications of methylglyoxal synthase complexed with phosphoglycolohydroxamic acid as observed by X-ray crystallography and NMR spectroscopy.
Biochemistry, 40, 2001
2R5V
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HYDROXYMANDELATE SYNTHASE CRYSTAL STRUCTURE
Descriptor:PCZA361.1, COBALT (II) ION, (2S)-hydroxy(4-hydroxyphenyl)ethanoic acid, ...
Authors:Brownlee, J.M., He, P., Moran, G.R., Harrison, D.H.T.
Deposit date:2007-09-04
Release date:2008-03-18
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Two roads diverged: the structure of hydroxymandelate synthase from Amycolatopsis orientalis in complex with 4-hydroxymandelate.
Biochemistry, 47, 2008