2IPW
Crystal Structure of C298A W219Y Aldose Reductase complexed with Dichlorophenylacetic acid
Summary for 2IPW
Entry DOI | 10.2210/pdb2ipw/pdb |
Related | 2INE 2INZ 2IQ0 2IQD 2IS7 |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2,6-DICHLOROPHENYL)ACETIC ACID, ... (4 entities in total) |
Functional Keywords | tim-barrel, ari, aldo-keto reductase, oxidoreductase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 36660.49 |
Authors | Harrison, D.H.T.,Pape, E.,Brownlee, J.M. (deposition date: 2006-10-12, release date: 2006-11-28, Last modification date: 2023-08-30) |
Primary citation | Brownlee, J.M.,Carlson, E.,Milne, A.C.,Pape, E.,Harrison, D.H. Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes. Bioorg.Chem., 34:424-444, 2006 Cited by PubMed: 17083960DOI: 10.1016/j.bioorg.2006.09.004 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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