2INZ

Crystal Structure of Aldose Reductase complexed with 2-Hydroxyphenylacetic Acid

Summary for 2INZ

Entry DOI	10.2210/pdb2inz/pdb
Related	2INE 2IPW 2IQ0 2IQD 2IS7 2ISF
Descriptor	Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2-HYDROXYPHENYL)ACETIC ACID, ... (4 entities in total)
Functional Keywords	tim-barrel, ari, aldo-keto reductase, oxidoreductase
Biological source	Homo sapiens (human)
Cellular location	Cytoplasm: P15121
Total number of polymer chains	1
Total formula weight	36662.70
Authors	Harrison, D.H.T.,Pape, E.,Carlson, E.,Brownlee, J.M. (deposition date: 2006-10-09, release date: 2006-11-21, Last modification date: 2023-08-30)
Primary citation	Brownlee, J.M.,Carlson, E.,Milne, A.C.,Pape, E.,Harrison, D.H. Structural and thermodynamic studies of simple aldose reductase-inhibitor complexes. Bioorg.Chem., 34:424-444, 2006 Cited by PubMed: 17083960 DOI: 10.1016/j.bioorg.2006.09.004 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation