Author results

1EQZ
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X-RAY STRUCTURE OF THE NUCLEOSOME CORE PARTICLE AT 2.5 A RESOLUTION
Descriptor:146 NUCLEOTIDES LONG DNA, PROTEIN (HISTONE H2A), PROTEIN (HISTONE H2B), ...
Authors:Hanson, B.L., Harp, J.M., Timm, D.E., Bunick, G.J.
Deposit date:2000-04-06
Release date:2000-04-17
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Asymmetries in the nucleosome core particle at 2.5 A resolution.
Acta Crystallogr.,Sect.D, 56, 2000
1QCN
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CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE
Descriptor:FUMARYLACETOACETATE HYDROLASE, CALCIUM ION, ACETATE ION, ...
Authors:Timm, D.E., Mueller, H.A., Bhanumoorthy, P., Harp, J.M., Bunick, G.J.
Deposit date:1999-05-14
Release date:2000-06-07
Last modified:2017-10-04
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Structure Fold.Des., 7, 1999
1QCO
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CRYSTAL STRUCTURE OF FUMARYLACETOACETATE HYDROLASE COMPLEXED WITH FUMARATE AND ACETOACETATE
Descriptor:FUMARYLACETOACETATE HYDROLASE, CALCIUM ION, NICKEL (II) ION, ...
Authors:Timm, D.E., Mueller, H.A., Bhanumoorthy, P., Harp, J.M., Bunick, G.J.
Deposit date:1999-05-17
Release date:2000-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Structure Fold.Des., 7, 1999
1QQJ
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CRYSTAL STRUCTURE OF MOUSE FUMARYLACETOACETATE HYDROLASE REFINED AT 1.55 ANGSTROM RESOLUTION
Descriptor:FUMARYLACETOACETATE HYDROLASE, CALCIUM ION, ACETATE ION, ...
Authors:Timm, D.E., Mueller, H.A., Bhanumoorthy, P., Harp, J.M., Bunick, G.J.
Deposit date:1999-06-07
Release date:2000-06-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Crystal structure and mechanism of a carbon-carbon bond hydrolase.
Structure Fold.Des., 7, 1999
1MT6
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STRUCTURE OF HISTONE H3 K4-SPECIFIC METHYLTRANSFERASE SET7/9 WITH ADOHCY
Descriptor:SET9, S-ADENOSYL-L-HOMOCYSTEINE
Authors:Jacobs, S.A., Harp, J.M., Devarakonda, S., Kim, Y., Rastinejad, F., Khorasanizadeh, S.
Deposit date:2002-09-20
Release date:2002-11-06
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:The active site of the SET domain is constructed on a knot
Nat.Struct.Biol., 9, 2002
1MUF
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STRUCTURE OF HISTONE H3 K4-SPECIFIC METHYLTRANSFERASE SET7/9
Descriptor:SET9
Authors:Jacobs, S.A., Harp, J.M., Devarakonda, S., Kim, Y., Rastinejad, F., Khorasanizadeh, S.
Deposit date:2002-09-23
Release date:2002-11-06
Last modified:2011-11-16
Method:X-RAY DIFFRACTION (2.26 Å)
Cite:The active site of the SET domain is constructed on a knot
Nat.Struct.Biol., 9, 2002
1R0N
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CRYSTAL STRUCTURE OF HETERODIMERIC ECDSYONE RECEPTOR DNA BINDING COMPLEX
Descriptor:Ecdsyone Response Element, Ecdysone Response Element, Retinoic acid receptor RXR-alpha, ...
Authors:Devarakonda, S., Harp, J.M., Kim, Y., Ozyhar, A., Rastinejad, F.
Deposit date:2003-09-22
Release date:2003-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.6 Å)
Cite:Structure of the heterodimeric Ecdysone Receptor DNA-binding complex
Embo J., 22, 2003
1R0O
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CRYSTAL STRUCTURE OF THE HETERODIMERIC ECDYSONE RECEPTOR DNA-BINDING COMPLEX
Descriptor:Ecdysone Response Element, Ultraspiracle protein, Ecdysone receptor, ...
Authors:Devarakonda, S., Harp, J.M., Kim, Y., Ozyhar, A., Rastinejad, F.
Deposit date:2003-09-22
Release date:2003-10-21
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structure of the Heterodimeric Ecdysone Receptor DNA-binding Complex
Embo J., 22, 2003
1OSV
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STRUCTURAL BASIS FOR BILE ACID BINDING AND ACTIVATION OF THE NUCLEAR RECEPTOR FXR
Descriptor:Bile acid receptor, Nuclear receptor coactivator 2, 6-ETHYL-CHENODEOXYCHOLIC ACID
Authors:Mi, L.Z., Devarakonda, S., Harp, J.M., Han, Q., Pellicciari, R., Willson, T.M., Khorasanizadeh, S., Rastinejad, F.
Deposit date:2003-03-20
Release date:2004-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
Mol.Cell, 11, 2003
1OT7
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STRUCTURAL BASIS FOR 3-DEOXY-CDCA BINDING AND ACTIVATION OF FXR
Descriptor:Bile Acid Receptor, dodecamer peptide fragment of RPGR-interacting protein 1, 6-ETHYL-CHENODEOXYCHOLIC ACID, ...
Authors:Mi, L.Z., Devarakonda, S., Harp, J.M., Han, Q., Pellicciari, R., Willson, T.M., Khorasanizadeh, S., Rastinejad, F.
Deposit date:2003-03-21
Release date:2004-03-23
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Structural Basis for Bile Acid Binding and Activation of the Nuclear Receptor FXR
Mol.Cell, 11, 2003
2GLK
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HIGH-RESOLUTION STUDY OF D-XYLOSE ISOMERASE, 0.94A RESOLUTION.
Descriptor:Xylose isomerase, MANGANESE (II) ION, GLYCEROL
Authors:Katz, A.K., Carrell, H.L., Hanson, B.L., Harp, J.M., Glusker, J.P., Bunick, G.J.
Deposit date:2006-04-05
Release date:2006-05-16
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (0.94 Å)
Cite:Locating active-site hydrogen atoms in D-xylose isomerase: Time-of-flight neutron diffraction.
Proc.Natl.Acad.Sci.Usa, 103, 2006
3C8E
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CRYSTAL STRUCTURE ANALYSIS OF YGHU FROM E. COLI
Descriptor:yghU, glutathione S-transferase homologue, GLUTATHIONE
Authors:Harp, J., Ladner, J.E., Schaab, M.R., Stourman, N.V., Armstrong, R.N.
Deposit date:2008-02-11
Release date:2009-02-24
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure and Function of YghU, a Nu-Class Glutathione Transferase Related to YfcG from Escherichia coli.
Biochemistry, 50, 2011
3GX0
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CRYSTAL STRUCTURE OF GSH-DEPENDENT DISULFIDE BOND OXIDOREDUCTASE
Descriptor:GST-like protein yfcG, OXIDIZED GLUTATHIONE DISULFIDE
Authors:Ladner, J.E., Harp, J.M., Wadington, M.C., Armstrong, R.N.
Deposit date:2009-04-01
Release date:2009-07-07
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Analysis of the structure and function of YfcG from Escherichia coli reveals an efficient and unique disulfide bond reductase.
Biochemistry, 48, 2009
3G1Q
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CRYSTAL STRUCTURE OF STEROL 14-ALPHA DEMETHYLASE (CYP51) FROM TRYPANOSOMA BRUCEI IN LIGAND FREE STATE
Descriptor:Sterol 14-alpha-demethylase, PROTOPORPHYRIN IX CONTAINING FE
Authors:Lepesheva, G.I., Hargrove, T.Y., Harp, J., Wawrzak, Z., Waterman, M.R., Park, H.
Deposit date:2009-01-30
Release date:2009-10-06
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.
J.Biol.Chem., 285, 2010
3GW9
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CRYSTAL STRUCTURE OF STEROL 14-ALPHA DEMETHYLASE (CYP51) FROM TRYPANOSOMA BRUCEI BOUND TO AN INHIBITOR N-(1-(2,4-DICHLOROPHENYL)-2-(1H-IMIDAZOL-1-YL)ETHYL)-4-(5-PHENYL-1,3,4-OXAZIAZOL-2-YL)BENZAMIDE
Descriptor:STEROL 14ALPHA-DEMETHYLASE, PROTOPORPHYRIN IX CONTAINING FE, N-[(1R)-1-(2,4-dichlorophenyl)-2-(1H-imidazol-1-yl)ethyl]-4-(5-phenyl-1,3,4-oxadiazol-2-yl)benzamide
Authors:Lepesheva, G.I., Hargrove, T.Y., Harp, J., Wawrzak, Z., Waterman, M.R.
Deposit date:2009-03-31
Release date:2009-11-17
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.87 Å)
Cite:Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections.
J.Biol.Chem., 285, 2010
3NT1
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HIGH RESOLUTION STRUCTURE OF NAPROXEN:COX-2 COMPLEX.
Descriptor:Prostaglandin-endoperoxide synthase 2, N-ACETYL-D-GLUCOSAMINE, B-OCTYLGLUCOSIDE, ...
Authors:Duggan, K.C., Musee, J., Walters, M.J., Harp, J.M., Kiefer, J.R., Oates, J.A., Marnett, L.J.
Deposit date:2010-07-02
Release date:2010-09-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (1.73 Å)
Cite:Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
J.Biol.Chem., 285, 2010
3NTB
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STRUCTURE OF 6-METHYLTHIO NAPROXEN ANALOG BOUND TO MCOX-2.
Descriptor:Prostaglandin-endoperoxide synthase 2, PROTOPORPHYRIN IX CONTAINING FE, N-ACETYL-D-GLUCOSAMINE, ...
Authors:Duggan, K.C., Musee, J., Walters, M.J., Harp, J.M., Kiefer, J.R., Oates, J.A., Marnett, L.J.
Deposit date:2010-07-03
Release date:2010-09-01
Last modified:2017-11-08
Method:X-RAY DIFFRACTION (2.27 Å)
Cite:Molecular basis for cyclooxygenase inhibition by the non-steroidal anti-inflammatory drug naproxen.
J.Biol.Chem., 285, 2010
3MF6
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COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE
Descriptor:Endo-1,4-beta-xylanase, SULFATE ION
Authors:Morin, A., Harp, J.M.
Deposit date:2010-04-01
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.28 Å)
Cite:Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
3MF9
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COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE
Descriptor:Endo-1,4-beta-xylanase, SULFATE ION
Authors:Morin, A., Harp, J.M.
Deposit date:2010-04-01
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
3MFA
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COMPUTATIONALLY DESIGNED ENDO-1,4-BETA-XYLANASE
Descriptor:Endo-1,4-beta-xylanase, SULFATE ION
Authors:Morin, A., Harp, J.M.
Deposit date:2010-04-01
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.63 Å)
Cite:Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
3MFC
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COMPUTATIONALLY DESIGNED END0-1,4-BETA,XYLANASE
Descriptor:Endo-1,4-beta-xylanase, SULFATE ION
Authors:Morin, A., Harp, J.M.
Deposit date:2010-04-01
Release date:2010-11-10
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Computational design of an endo-1,4-{beta}-xylanase ligand binding site.
Protein Eng.Des.Sel., 24, 2011
3TDM
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COMPUTATIONALLY DESIGNED TIM-BARREL PROTEIN, HALFFLR
Descriptor:Computationally designed two-fold symmetric TIM-barrel protein, FLR (half molecule), PHOSPHATE ION
Authors:Harp, J.M., Fortenberry, C., Bowman, E., Profitt, W., Dorr, B., Mizoue, L.
Deposit date:2011-08-11
Release date:2011-11-16
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (2.4 Å)
Cite:Exploring symmetry as an avenue to the computational design of large protein domains.
J.Am.Chem.Soc., 133, 2011
3TDN
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COMPUTATIONALLY DESIGNED TWO-FOLD SYMMETRIC TIM-BARREL PROTEIN, FLR
Descriptor:FLR SYMMETRIC ALPHA-BETA TIM BARREL
Authors:Harp, J.M., Fortenberry, C., Bowman, E., Profitt, W., Dorr, B., Mizoue, L., Meiler, J.
Deposit date:2011-08-11
Release date:2011-11-16
Last modified:2011-11-23
Method:X-RAY DIFFRACTION (1.4 Å)
Cite:Exploring symmetry as an avenue to the computational design of large protein domains.
J.Am.Chem.Soc., 133, 2011
3R3E
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THE GLUTATHIONE BOUND STRUCTURE OF YQJG, A GLUTATHIONE TRANSFERASE HOMOLOG FROM ESCHERICHIA COLI K-12
Descriptor:Uncharacterized protein yqjG, GLUTATHIONE, SULFATE ION
Authors:Branch, M.C., Cook, P.D., Harp, J.M., Armstrong, R.N.
Deposit date:2011-03-15
Release date:2012-03-14
Method:X-RAY DIFFRACTION (2.205 Å)
Cite:Crystal Structure Analysis of yqjG from Escherichia Coli K-12
To be Published
4YP3
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MUTANT HUMAN DNA POLYMERASE ETA Q38A/R61A INSERTING DCTP OPPOSITE AN 8-OXOGUANINE LESION
Descriptor:DNA polymerase eta, DNA (5'-D(*TP*(8OG)P*AP*TP*GP*AP*CP*GP*CP*T)-3'), DNA (5'-D(*AP*GP*CP*GP*TP*CP*AP*T)-3'), ...
Authors:Su, Y., Patra, A., Harp, J.M., Egli, M., Guengerich, F.P.
Deposit date:2015-03-12
Release date:2015-05-13
Last modified:2017-09-20
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
J.Biol.Chem., 290, 2015
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