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3C0T
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STRUCTURE OF THE SCHIZOSACCHAROMYCES POMBE MEDIATOR SUBCOMPLEX MED8C/18
分子名称:Mediator of RNA polymerase II transcription subunit 18, Mediator of RNA polymerase II transcription subunit 8
著者Lariviere, L., Seizl, M., van Wageningen, S., Roether, S., van de Pasch, L., Feldmann, H., Straesser, K., Hahn, S., Holstege, C.P., Cramer, P.
登録日2008-01-21
公開日2008-04-22
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Structure-system correlation identifies a gene regulatory Mediator submodule
Genes Dev., 22, 2008
6MZC
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HUMAN TFIID BC CORE
分子名称:Transcription initiation factor TFIID subunit 2, Transcription initiation factor TFIID subunit 4, Transcription initiation factor TFIID subunit 5, ...
著者Patel, A.B., Louder, R.K., Greber, B.J., Grunberg, S., Luo, J., Fang, J., Liu, Y., Ranish, J., Hahn, S., Nogales, E.
登録日2018-11-05
公開日2018-11-28
最終更新日2019-01-02
実験手法ELECTRON MICROSCOPY (4.5 Å)
主引用文献Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6MZD
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HUMAN TFIID LOBE A CANONICAL
分子名称:Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 3, Transcription initiation factor TFIID subunit 4, ...
著者Patel, A.B., Louder, R.K., Greber, B.J., Grunberg, S., Luo, J., Fang, J., Liu, Y., Ranish, J., Hahn, S., Nogales, E.
登録日2018-11-05
公開日2018-11-28
最終更新日2019-01-02
実験手法ELECTRON MICROSCOPY (9.8 Å)
主引用文献Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6MZL
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HUMAN TFIID CANONICAL STATE
分子名称:Transcription initiation factor TFIID subunit 1, Transcription initiation factor TFIID subunit 2, Transcription initiation factor TFIID subunit 3, ...
著者Patel, A.B., Louder, R.K., Greber, B.J., Grunberg, S., Luo, J., Fang, J., Liu, Y., Ranish, J., Hahn, S., Nogales, E.
登録日2018-11-05
公開日2018-11-28
最終更新日2019-01-02
実験手法ELECTRON MICROSCOPY (23 Å)
主引用文献Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
6MZM
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HUMAN TFIID BOUND TO PROMOTER DNA AND TFIIA
分子名称:Transcription initiation factor TFIID subunit 1, TAF1, Transcription initiation factor TFIID subunit 2, ...
著者Patel, A.B., Louder, R.K., Greber, B.J., Grunberg, S., Luo, J., Fang, J., Liu, Y., Ranish, J., Hahn, S., Nogales, E.
登録日2018-11-05
公開日2018-11-28
最終更新日2019-01-02
実験手法ELECTRON MICROSCOPY (7.5 Å)
主引用文献Structure of human TFIID and mechanism of TBP loading onto promoter DNA.
Science, 362, 2018
1YTB
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CRYSTAL STRUCTURE OF A YEAST TBP/TATA-BOX COMPLEX
分子名称:DNA (29MER), PROTEIN (TATA BINDING PROTEIN (TBP))
著者Kim, Y., Geiger, J.H., Hahn, S., Sigler, P.B.
登録日1994-09-28
公開日1995-01-26
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal structure of a yeast TBP/TATA-box complex.
Nature, 365, 1993
2LPB
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STRUCTURE OF THE COMPLEX OF THE CENTRAL ACTIVATION DOMAIN OF GCN4 BOUND TO THE MEDIATOR CO-ACTIVATOR DOMAIN 1 OF GAL11/MED15
分子名称:Mediator of RNA polymerase II transcription subunit 15, General control protein GCN4
著者Brzovic, P.S., Heikaus, C.C., Kisselev, L., Vernon, R., Herbig, E., Pacheco, D., Warfield, L., Littlefield, P., Baker, D., Klevit, R.E., Hahn, S.
登録日2012-02-07
公開日2012-02-22
実験手法SOLUTION NMR
主引用文献The acidic transcription activator Gcn4 binds the mediator subunit Gal11/Med15 using a simple protein interface forming a fuzzy complex.
Mol.Cell, 44, 2011
6ALY
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SOLUTION STRUCTURE OF YEAST MED15 ABD2 RESIDUES 277-368
分子名称:Mediator of RNA polymerase II transcription subunit 15
著者Tuttle, L.M., Pacheco, D., Warfield, L., Hahn, S., Klevit, R.E.
登録日2017-08-08
公開日2018-03-21
最終更新日2019-02-20
実験手法SOLUTION NMR
主引用文献Gcn4-Mediator Specificity Is Mediated by a Large and Dynamic Fuzzy Protein-Protein Complex.
Cell Rep, 22, 2018
4JV6
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THE CRYSTAL STRUCTURE OF PDE6D IN COMPLEX TO INHIBITOR-1
分子名称:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, 1-benzyl-2-phenyl-1H-benzimidazole
著者Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
登録日2013-03-25
公開日2013-05-22
最終更新日2013-06-05
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JV8
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THE CRYSTAL STRUCTURE OF PDE6D IN COMPLEX WITH RAC-S1
分子名称:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, (6R)-6-(pyridin-2-yl)-5,6-dihydrobenzimidazo[1,2-c]quinazoline
著者Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
登録日2013-03-25
公開日2013-05-22
最終更新日2013-06-05
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JVB
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CRYSTAL STRUCTURE OF PDE6D IN COMPLEX WITH THE INHIBITOR RAC-2
分子名称:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, 1-benzyl-2-(4-{[(2R)-2-(2-phenyl-1H-benzimidazol-1-yl)pent-4-en-1-yl]oxy}phenyl)-1H-benzimidazole
著者Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
登録日2013-03-25
公開日2013-05-22
最終更新日2013-06-05
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
4JVF
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THE CRYSTAL STRUCTURE OF PDE6D IN COMPLEX WITH THE INHIBITOR (S)-5
分子名称:Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta, (2S)-2-(2-phenyl-1H-benzimidazol-1-yl)-2-(piperidin-4-yl)ethyl 1-(1-benzyl-1H-benzimidazol-2-yl)piperidine-4-carboxylate
著者Gunther, Z., Papke, B., Ismail, S., Vartak, N., Chandra, A., Hoffmann, M., Hahn, S., Triola, G., Wittinghofer, A., Bastiaens, P., Waldmann, H.
登録日2013-03-25
公開日2013-05-22
最終更新日2017-11-15
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Small molecule inhibition of the KRAS PDEd interaction impairs oncogenic KRAS signalling
Nature, 497, 2013
3WQQ
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CRYSTAL STRUCTURE OF PFDXR COMPLEXED WITH INHIBITOR-3
分子名称:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Tanaka, N., Umeda, T.
登録日2014-01-31
公開日2014-11-26
実験手法X-RAY DIFFRACTION (2.25 Å)
主引用文献Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC.
J.Med.Chem., 57, 2014
3WQR
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CRYSTAL STRUCTURE OF PFDXR COMPLEXED WITH INHIBITOR-12
分子名称:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Tanaka, N., Umeda, T.
登録日2014-01-31
公開日2014-11-26
実験手法X-RAY DIFFRACTION (1.97 Å)
主引用文献Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC.
J.Med.Chem., 57, 2014
3WQS
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CRYSTAL STRUCTURE OF PFDXR COMPLEXED WITH INHIBITOR-126
分子名称:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Tanaka, N., Umeda, T.
登録日2014-01-31
公開日2014-11-26
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Binding Modes of Reverse Fosmidomycin Analogs toward the Antimalarial Target IspC.
J.Med.Chem., 57, 2014
1TFR
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RNASE H FROM BACTERIOPHAGE T4
分子名称:T4 RNASE H, MAGNESIUM ION
著者Mueser, T.C., Nossal, N.G., Hyde, C.C.
登録日1996-04-27
公開日1996-11-08
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献Structure of bacteriophage T4 RNase H, a 5' to 3' RNA-DNA and DNA-DNA exonuclease with sequence similarity to the RAD2 family of eukaryotic proteins.
Cell(Cambridge,Mass.), 85, 1996
4KP7
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STRUCTURE OF PLASMODIUM ISPC IN COMPLEX WITH A BETA-THIA-ISOSTERE DERIVATIVE OF FOSMIDOMYCIN
分子名称:1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplast, MANGANESE (III) ION, ...
著者Kunfermann, A., Bacher, A., Groll, M.
登録日2013-05-13
公開日2013-10-02
最終更新日2014-02-12
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献IspC as Target for Antiinfective Drug Discovery: Synthesis, Enantiomeric Separation, and Structural Biology of Fosmidomycin Thia Isosters.
J.Med.Chem., 56, 2013