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1JCU
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SOLUTION STRUCTURE OF MTH1692 PROTEIN FROM METHANOBACTERIUM THERMOAUTOTROPHICUM
Descriptor:conserved protein MTH1692
Authors:Kozlov, G., Ekiel, I., Gehring, K.
Deposit date:2001-06-11
Release date:2002-07-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics.
Proc.Natl.Acad.Sci.USA, 99, 2002
1JDQ
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SOLUTION STRUCTURE OF TM006 PROTEIN FROM THERMOTOGA MARITIMA
Descriptor:HYPOTHETICAL PROTEIN TM0983
Authors:Denisov, A.Y., Finak, G., Yee, A., Kozlov, G., Gehring, K., Arrowsmith, C.H.
Deposit date:2001-06-14
Release date:2002-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics.
Proc.Natl.Acad.Sci.USA, 99, 2002
1JE3
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SOLUTION STRUCTURE OF EC005 FROM ESCHERICHIA COLI
Descriptor:HYPOTHETICAL 8.6 KDA PROTEIN IN AMYA-FLIE INTERGENIC REGION
Authors:Yee, A., Gutierrez, P., Kozlov, G., Denisov, A., Gehring, K., Arrowsmith, C.
Deposit date:2001-06-15
Release date:2002-03-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics.
Proc.Natl.Acad.Sci.USA, 99, 2002
1JJG
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SOLUTION STRUCTURE OF MYXOMA VIRUS PROTEIN M156R
Descriptor:M156R
Authors:Ramelot, T.A., Cort, J.R., Yee, A.A., Arrowsmith, C.H., Kennedy, M.A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2001-07-05
Release date:2002-03-06
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Myxoma virus immunomodulatory protein M156R is a structural mimic of eukaryotic translation initiation factor eIF2alpha.
J.Mol.Biol., 322, 2002
1JRM
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NMR STRUCTURE OF MTH0637. ONTARIO CENTRE FOR STRUCTURAL PROTEOMICS TARGET MTH0637_1_104; NORTHEAST STRUCTURAL GENOMICS TARGET TT135
Descriptor:CONSERVED HYPOTHETICAL PROTEIN mth637
Authors:Pineda-Lucena, A., Northeast Structural Genomics Consortium (NESG)
Deposit date:2001-08-14
Release date:2002-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics.
Proc.Natl.Acad.Sci.USA, 99, 2002
1JW2
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SOLUTION STRUCTURE OF HEMOLYSIN EXPRESSION MODULATING PROTEIN HHA FROM ESCHERICHIA COLI. ONTARIO CENTRE FOR STRUCTURAL PROTEOMICS TARGET EC0308_1_72; NORTHEAST STRUCTURAL GENOMICS TARGET ET88
Descriptor:HEMOLYSIN EXPRESSION MODULATING PROTEIN Hha
Authors:Chang, X., Yee, A., Savchenko, A., Edwards, A.M., Arrowsmith, C.H., Northeast Structural Genomics Consortium (NESG)
Deposit date:2001-09-02
Release date:2002-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics
Proc.Natl.Acad.Sci.USA, 99, 2002
1JW3
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SOLUTION STRUCTURE OF METHANOBACTERIUM THERMOAUTOTROPHICUM PROTEIN 1598. ONTARIO CENTRE FOR STRUCTURAL PROTEOMICS TARGET MTH1598_1_140; NORTHEAST STRUCTURAL GENOMICS TARGET TT6
Descriptor:Conserved Hypothetical Protein MTH1598
Authors:Chang, X., Connelly, G., Yee, A., Kennedy, M.A., Edwards, A.M., Arrowsmith, C.H., Northeast Structural Genomics Consortium (NESG)
Deposit date:2001-09-02
Release date:2002-02-27
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:An NMR approach to structural proteomics.
Proc.Natl.Acad.Sci.USA, 99, 2002
1NEE
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STRUCTURE OF ARCHAEAL TRANSLATION FACTOR AIF2BETA FROM METHANOBACTERIUM THERMOAUTROPHICUM
Descriptor:Probable translation initiation factor 2 beta subunit, ZINC ION
Authors:Gutierrez, P., Trempe, J.F., Siddiqui, N., Arrowsmith, C., Gehring, K.
Deposit date:2002-12-11
Release date:2004-03-09
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Structure of the archaeal translation initiation factor aIF2beta from Methanobacterium thermoautotrophicum: Implications for translation initiation.
Protein Sci., 13, 2004
1RYJ
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SOLUTION NMR STRUCTURE OF PROTEIN MTH1743 FROM METHANOBACTERIUM THERMOAUTOTROPHICUM. ONTARIO CENTRE FOR STRUCTURAL PROTEOMICS TARGET MTH1743_1_70; NORTHEAST STRUCTURAL GENOMICS CONSORTIUM TARGET TT526.
Descriptor:unknown
Authors:Yee, A., Chang, X., Pineda-Lucena, A., Wu, B., Semesi, A., Le, B., Ramelot, T., Lee, G.M., Bhattacharyya, S., Gutierrez, P., Denisov, A., Lee, C.H., Cort, J.R., Kozlov, G., Liao, J., Finak, G., Chen, L., Wishart, D., Lee, W., McIntosh, L.P., Gehring, K., Kennedy, M.A., Edwards, A.M., Arrowsmith, C.H., Northeast Structural Genomics Consortium (NESG)
Deposit date:2003-12-22
Release date:2004-02-24
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:AN NMR APPROACH TO STRUCTURAL PROTEOMICS
Proc.Natl.Acad.Sci.USA, 99, 2002
1SG5
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SOLUTION STRUCTURE OF YAEO, A RHO-SPECIFIC INHIBITOR OF TRANSCRIPTION TERMINATION
Descriptor:orf, hypothetical protein
Authors:Gutierrez, P., Gehring, K., Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2004-02-23
Release date:2005-07-12
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution Structure of YaeO, a Rho-specific Inhibitor of Transcription Termination
J.Biol.Chem., 282, 2007
1Y00
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SOLUTION STRUCTURE OF THE CARBON STORAGE REGULATOR PROTEIN CSRA
Descriptor:Carbon storage regulator
Authors:Gutierrez, P., Li, Y., Osborne, M.J., Liu, Q., Gehring, K., Montreal-Kingston Bacterial Structural Genomics Initiative (BSGI)
Deposit date:2004-11-13
Release date:2005-06-21
Last modified:2011-07-13
Method:SOLUTION NMR
Cite:Solution structure of the carbon storage regulator protein CsrA from Escherichia coli.
J.Bacteriol., 187, 2005
4BB5
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FREE-WILSON AND STRUCTURAL APPROACHES TO CO-OPTIMISING HUMAN AND RODENT ISOFORM POTENCY FOR 11B-HYDROXYSTEROID DEHYDROGENASE TYPE 1 11B-HSD1 INHIBITORS
Descriptor:CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-cyclopentyl-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-2-[[(3S)-oxolan-3-yl]amino]pyrimidine-5-carboxamide
Authors:Goldberg, F.W., Leach, A.G., Scott, J.S., Snelson, W.L., Groombridge, S.D., Donald, C.S., Bennett, S.N.L., Bodin, C., Morentin Gutierrez, P., Gyte, A.C.
Deposit date:2012-09-20
Release date:2012-11-28
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (2.2 Å)
Cite:Free-Wilson and Structural Approaches to Co-Optimising Human and Rodent Isoform Potency for 11Beta-Hydroxysteroid Dehydrogenase Type 1 (11Beta-Hsd1) Inhibitors
J.Med.Chem., 55, 2012
4BB6
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FREE-WILSON AND STRUCTURAL APPROACHES TO CO-OPTIMISING HUMAN AND RODENT ISOFORM POTENCY FOR 11B-HYDROXYSTEROID DEHYDROGENASE TYPE 1 11B-HSD1 INHIBITORS
Descriptor:CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 6-(4-methylpiperazin-1-yl)-N-[(1R,3S)-5-oxidanyl-2-adamantyl]-2-propylsulfanyl-pyridine-3-carboxamide, ...
Authors:Goldberg, F.W., Leach, A.G., Scott, J.S., Snelson, W.L., Groombridge, S.D., Donald, C.S., Bennett, S.N.L., Bodin, C., Morentin Gutierrez, P., Gyte, A.C.
Deposit date:2012-09-20
Release date:2012-11-28
Last modified:2012-12-26
Method:X-RAY DIFFRACTION (2.55 Å)
Cite:Free-Wilson and Structural Approaches to Co- Optimising Human and Rodent Isoform Potency for 11Beta-Hydroxysteroid Dehydrogenase Type 1 (11Beta-Hsd1) Inhibitors
J.Med.Chem., 55, 2012
4C7J
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11B-HYDROXYSTEROID DEHYDROGENASE TYPE I IN COMPLEX WITH INHIBITOR
Descriptor:CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-cyclopropyl-2-(2-hydroxyethyloxy)-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-1,3-thiazole-5-carboxamide
Authors:Goldberg, F.W., Dossetter, A.G., Scott, J.S., Robb, G.R., Boyd, S., Groombridge, S.D., Kemmitt, P.D., Sjogren, T., Morentin Gutierrez, P., de Schoolmeester, J., Swales, J.G., Turnbull, A.V., Wild, M.J.
Deposit date:2013-09-23
Release date:2014-09-03
Last modified:2018-04-04
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:Optimization of Brain Penetrant 11Beta-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet- Induced Obese Mice.
J.Med.Chem., 57, 2014
4C7K
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11B-HYDROXYSTEROID DEHYDROGENASE TYPE I IN COMPLEX WITH INHIBITOR
Descriptor:CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-ethyl-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-4-[(2R)-oxolan-2-yl]-1,3-thiazole-5-carboxamide
Authors:Goldberg, F.W., Dossetter, A.G., Scott, J.S., Robb, G.R., Boyd, S., Groombridge, S.D., Kemmitt, P.D., Sjogren, T., Morentin Gutierrez, P., de Schoolmeester, J., Swales, J.G., Turnbull, A.V., Wild, M.J.
Deposit date:2013-09-23
Release date:2014-03-05
Last modified:2017-06-28
Method:X-RAY DIFFRACTION (1.91 Å)
Cite:Optimization of Brain Penetrant 11Beta-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet- Induced Obese Mice.
J.Med.Chem., 57, 2014