4C7K
11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor
Summary for 4C7K
Entry DOI | 10.2210/pdb4c7k/pdb |
Related | 4C7J |
Descriptor | CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 2-ethyl-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-4-[(2R)-oxolan-2-yl]-1,3-thiazole-5-carboxamide, ... (4 entities in total) |
Functional Keywords | oxidoreductase, cns penetration, structure-based design |
Biological source | HOMO SAPIENS (HUMAN) |
Cellular location | Endoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845 |
Total number of polymer chains | 4 |
Total formula weight | 122696.74 |
Authors | Goldberg, F.W.,Dossetter, A.G.,Scott, J.S.,Robb, G.R.,Boyd, S.,Groombridge, S.D.,Kemmitt, P.D.,Sjogren, T.,Morentin Gutierrez, P.,de Schoolmeester, J.,Swales, J.G.,Turnbull, A.V.,Wild, M.J. (deposition date: 2013-09-23, release date: 2014-03-05, Last modification date: 2023-12-20) |
Primary citation | Goldberg, F.W.,Dossetter, A.G.,Scott, J.S.,Robb, G.R.,Boyd, S.,Groombridge, S.D.,Kemmitt, P.D.,Sjogren, T.,Gutierrez, P.M.,Deschoolmeester, J.,Swales, J.G.,Turnbull, A.V.,Wild, M.J. Optimization of Brain Penetrant 11Beta-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet- Induced Obese Mice. J.Med.Chem., 57:970-, 2014 Cited by PubMed: 24422550DOI: 10.1021/JM4016729 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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