4BB5

Free-Wilson and Structural Approaches to Co-optimising Human and Rodent Isoform Potency for 11b-Hydroxysteroid Dehydrogenase Type 1 11b-HSD1 Inhibitors

Summary for 4BB5

Entry DOI	10.2210/pdb4bb5/pdb
Related	1XU7 1XU9 2BEL 4BB6
Descriptor	CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-cyclopentyl-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-2-[[(3S)-oxolan-3-yl]amino]pyrimidine-5-carboxamide, ... (4 entities in total)
Functional Keywords	oxidoreductase
Biological source	HOMO SAPIENS (HUMAN)
Cellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein: P28845
Total number of polymer chains	4
Total formula weight	134403.10
Authors	Goldberg, F.W.,Leach, A.G.,Scott, J.S.,Snelson, W.L.,Groombridge, S.D.,Donald, C.S.,Bennett, S.N.L.,Bodin, C.,Morentin Gutierrez, P.,Gyte, A.C. (deposition date: 2012-09-20, release date: 2012-11-28, Last modification date: 2012-12-26)
Primary citation	Goldberg, F.W.,Leach, A.G.,Scott, J.S.,Snelson, W.L.,Groombridge, S.D.,Donald, C.S.,Bennett, S.N.L.,Bodin, C.,Morentin Gutierrez, P.,Gyte, A.C. Free-Wilson and Structural Approaches to Co-Optimising Human and Rodent Isoform Potency for 11Beta-Hydroxysteroid Dehydrogenase Type 1 (11Beta-Hsd1) Inhibitors J.Med.Chem., 55:10652-, 2012 Cited by PubMed: 23153367 DOI: 10.1021/JM3013163 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation