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4C7J

11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor

Summary for 4C7J
Entry DOI10.2210/pdb4c7j/pdb
Related4C7K
DescriptorCORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, 4-cyclopropyl-2-(2-hydroxyethyloxy)-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-1,3-thiazole-5-carboxamide, ... (4 entities in total)
Functional Keywordsoxidoreductase, cns penetration, structure-based design
Biological sourceHOMO SAPIENS (HUMAN)
Cellular locationEndoplasmic reticulum membrane ; Single-pass type II membrane protein : P28845
Total number of polymer chains4
Total formula weight123081.14
Authors
Primary citationGoldberg, F.W.,Dossetter, A.G.,Scott, J.S.,Robb, G.R.,Boyd, S.,Groombridge, S.D.,Kemmitt, P.D.,Sjogren, T.,Gutierrez, P.M.,Deschoolmeester, J.,Swales, J.G.,Turnbull, A.V.,Wild, M.J.
Optimization of Brain Penetrant 11Beta-Hydroxysteroid Dehydrogenase Type I Inhibitors and in Vivo Testing in Diet- Induced Obese Mice.
J.Med.Chem., 57:970-, 2014
Cited by
PubMed: 24422550
DOI: 10.1021/JM4016729
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.16 Å)
Structure validation

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