4C7J
11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B, C, D (A, B, C, D) | CORTICOSTEROID 11-BETA-DEHYDROGENASE ISOZYME 1 | polymer | 269 | 29648.4 | 4 | UniProt (P28845) Pfam (PF00106) | HOMO SAPIENS (HUMAN) | 11-BETA-HYDROXYSTEROID DEHYDROGENASE 1,11-DH, 11-BETA-HSD1,11B-HYDROXYSTEROID DEHYDROGENASE TYPE 1 |
| 2 | E, G, I, K (A, B, C, D) | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | non-polymer | 743.4 | 4 | Chemie (NAP) | |||
| 3 | F, H, J, L (A, B, C, D) | 4-cyclopropyl-2-(2-hydroxyethyloxy)-N-[(1S,3R)-5-oxidanyl-2-adamantyl]-1,3-thiazole-5-carboxamide | non-polymer | 378.5 | 4 | Chemie (4YQ) | |||
| 4 | M, N, O, P (A, B, C, D) | water | water | 18.0 | 605 | Chemie (HOH) |
Sequence modifications
A, B, C, D: 24 - 292 (UniProt: P28845)
| PDB | External Database | Details |
|---|---|---|
| Leu 179 | Met 179 | engineered mutation |
| Arg 262 | Leu 262 | engineered mutation |
| Ser 272 | Cys 272 | engineered mutation |
| Glu 278 | Phe 278 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 118593.6 | |
| Non-Polymers* | Number of molecules | 8 |
| Total formula weight | 4487.6 | |
| All* | Total formula weight | 123081.1 |
