4C7J
11b-Hydroxysteroid Dehydrogenase Type I in complex with inhibitor
Functional Information from GO Data
| Chain | GOid | namespace | contents |
| A | 0005496 | molecular_function | steroid binding |
| A | 0005783 | cellular_component | endoplasmic reticulum |
| A | 0005789 | cellular_component | endoplasmic reticulum membrane |
| A | 0006706 | biological_process | steroid catabolic process |
| A | 0008202 | biological_process | steroid metabolic process |
| A | 0016020 | cellular_component | membrane |
| A | 0016491 | molecular_function | oxidoreductase activity |
| A | 0030324 | biological_process | lung development |
| A | 0042803 | molecular_function | protein homodimerization activity |
| A | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| A | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| A | 0050661 | molecular_function | NADP binding |
| A | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| A | 0102196 | molecular_function | cortisol dehydrogenase activity |
| B | 0005496 | molecular_function | steroid binding |
| B | 0005783 | cellular_component | endoplasmic reticulum |
| B | 0005789 | cellular_component | endoplasmic reticulum membrane |
| B | 0006706 | biological_process | steroid catabolic process |
| B | 0008202 | biological_process | steroid metabolic process |
| B | 0016020 | cellular_component | membrane |
| B | 0016491 | molecular_function | oxidoreductase activity |
| B | 0030324 | biological_process | lung development |
| B | 0042803 | molecular_function | protein homodimerization activity |
| B | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| B | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| B | 0050661 | molecular_function | NADP binding |
| B | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| B | 0102196 | molecular_function | cortisol dehydrogenase activity |
| C | 0005496 | molecular_function | steroid binding |
| C | 0005783 | cellular_component | endoplasmic reticulum |
| C | 0005789 | cellular_component | endoplasmic reticulum membrane |
| C | 0006706 | biological_process | steroid catabolic process |
| C | 0008202 | biological_process | steroid metabolic process |
| C | 0016020 | cellular_component | membrane |
| C | 0016491 | molecular_function | oxidoreductase activity |
| C | 0030324 | biological_process | lung development |
| C | 0042803 | molecular_function | protein homodimerization activity |
| C | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| C | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| C | 0050661 | molecular_function | NADP binding |
| C | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| C | 0102196 | molecular_function | cortisol dehydrogenase activity |
| D | 0005496 | molecular_function | steroid binding |
| D | 0005783 | cellular_component | endoplasmic reticulum |
| D | 0005789 | cellular_component | endoplasmic reticulum membrane |
| D | 0006706 | biological_process | steroid catabolic process |
| D | 0008202 | biological_process | steroid metabolic process |
| D | 0016020 | cellular_component | membrane |
| D | 0016491 | molecular_function | oxidoreductase activity |
| D | 0030324 | biological_process | lung development |
| D | 0042803 | molecular_function | protein homodimerization activity |
| D | 0043231 | cellular_component | intracellular membrane-bounded organelle |
| D | 0047022 | molecular_function | 7-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| D | 0050661 | molecular_function | NADP binding |
| D | 0070524 | molecular_function | 11-beta-hydroxysteroid dehydrogenase (NADP+) activity |
| D | 0102196 | molecular_function | cortisol dehydrogenase activity |
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 30 |
| Details | BINDING SITE FOR RESIDUE NAP A 1286 |
| Chain | Residue |
| A | GLY41 |
| A | MET93 |
| A | ASN119 |
| A | ILE121 |
| A | VAL168 |
| A | SER169 |
| A | TYR183 |
| A | LYS187 |
| A | LEU215 |
| A | GLY216 |
| A | LEU217 |
| A | SER43 |
| A | ILE218 |
| A | THR220 |
| A | THR222 |
| A | ALA223 |
| A | 4YQ1287 |
| A | HOH2015 |
| A | HOH2016 |
| A | HOH2018 |
| A | HOH2044 |
| A | HOH2096 |
| A | LYS44 |
| A | HOH2188 |
| A | GLY45 |
| A | ILE46 |
| A | ALA65 |
| A | ARG66 |
| A | SER67 |
| A | THR92 |
| site_id | AC2 |
| Number of Residues | 34 |
| Details | BINDING SITE FOR RESIDUE NAP B 1292 |
| Chain | Residue |
| B | GLY41 |
| B | ALA42 |
| B | SER43 |
| B | LYS44 |
| B | GLY45 |
| B | ILE46 |
| B | ALA65 |
| B | ARG66 |
| B | SER67 |
| B | THR92 |
| B | MET93 |
| B | ASN119 |
| B | ILE121 |
| B | VAL168 |
| B | SER169 |
| B | SER170 |
| B | TYR183 |
| B | LYS187 |
| B | LEU215 |
| B | GLY216 |
| B | LEU217 |
| B | ILE218 |
| B | THR220 |
| B | THR222 |
| B | ALA223 |
| B | 4YQ1293 |
| B | HOH2008 |
| B | HOH2009 |
| B | HOH2012 |
| B | HOH2032 |
| B | HOH2132 |
| B | HOH2164 |
| B | HOH2165 |
| B | HOH2166 |
| site_id | AC3 |
| Number of Residues | 35 |
| Details | BINDING SITE FOR RESIDUE NAP C 1282 |
| Chain | Residue |
| C | GLY41 |
| C | ALA42 |
| C | SER43 |
| C | LYS44 |
| C | GLY45 |
| C | ILE46 |
| C | ALA65 |
| C | ARG66 |
| C | SER67 |
| C | THR92 |
| C | MET93 |
| C | ASN119 |
| C | ILE121 |
| C | VAL168 |
| C | SER169 |
| C | SER170 |
| C | TYR183 |
| C | LYS187 |
| C | LEU215 |
| C | GLY216 |
| C | LEU217 |
| C | ILE218 |
| C | THR220 |
| C | THR222 |
| C | ALA223 |
| C | 4YQ1283 |
| C | HOH2010 |
| C | HOH2011 |
| C | HOH2012 |
| C | HOH2013 |
| C | HOH2014 |
| C | HOH2025 |
| C | HOH2061 |
| C | HOH2151 |
| C | HOH2152 |
| site_id | AC4 |
| Number of Residues | 29 |
| Details | BINDING SITE FOR RESIDUE NAP D 1283 |
| Chain | Residue |
| D | GLY41 |
| D | ALA42 |
| D | SER43 |
| D | LYS44 |
| D | GLY45 |
| D | ILE46 |
| D | ALA65 |
| D | ARG66 |
| D | SER67 |
| D | THR92 |
| D | MET93 |
| D | ASN119 |
| D | ILE121 |
| D | VAL168 |
| D | SER169 |
| D | SER170 |
| D | TYR183 |
| D | LYS187 |
| D | LEU215 |
| D | GLY216 |
| D | LEU217 |
| D | ILE218 |
| D | THR220 |
| D | THR222 |
| D | ALA223 |
| D | 4YQ1284 |
| D | HOH2007 |
| D | HOH2025 |
| D | HOH2074 |
| site_id | AC5 |
| Number of Residues | 13 |
| Details | BINDING SITE FOR RESIDUE 4YQ A 1287 |
| Chain | Residue |
| A | SER170 |
| A | TYR177 |
| A | TYR183 |
| A | LEU215 |
| A | GLY216 |
| A | LEU217 |
| A | MET233 |
| A | ASP259 |
| A | NAP1286 |
| A | HOH2097 |
| A | HOH2160 |
| B | TYR280 |
| B | TYR284 |
| site_id | AC6 |
| Number of Residues | 17 |
| Details | BINDING SITE FOR RESIDUE 4YQ B 1293 |
| Chain | Residue |
| A | TYR280 |
| A | TYR284 |
| B | THR124 |
| B | SER170 |
| B | LEU171 |
| B | TYR177 |
| B | TYR183 |
| B | LEU215 |
| B | GLY216 |
| B | LEU217 |
| B | THR222 |
| B | ALA226 |
| B | MET233 |
| B | ASP259 |
| B | NAP1292 |
| B | HOH2081 |
| B | HOH2164 |
| site_id | AC7 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE 4YQ C 1283 |
| Chain | Residue |
| C | THR124 |
| C | LEU126 |
| C | SER170 |
| C | TYR177 |
| C | TYR183 |
| C | LEU215 |
| C | GLY216 |
| C | LEU217 |
| C | THR222 |
| C | ALA226 |
| C | MET233 |
| C | ASP259 |
| C | NAP1282 |
| C | HOH2063 |
| C | HOH2151 |
| D | TYR280 |
| site_id | AC8 |
| Number of Residues | 10 |
| Details | BINDING SITE FOR RESIDUE 4YQ D 1284 |
| Chain | Residue |
| D | LEU126 |
| D | SER170 |
| D | TYR177 |
| D | TYR183 |
| D | LEU215 |
| D | LEU217 |
| D | ALA226 |
| D | ASP259 |
| D | NAP1283 |
| D | HOH2042 |
Functional Information from PROSITE/UniProt
| site_id | PS00061 |
| Number of Residues | 29 |
| Details | ADH_SHORT Short-chain dehydrogenases/reductases family signature. SlagkvayplVaaYSASKFALdGFFsSIR |
| Chain | Residue | Details |
| A | SER170-ARG198 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 1068 |
| Details | TOPO_DOM: Lumenal => ECO:0000255 |
| Chain | Residue | Details |
| A | GLU25-LYS292 | |
| B | GLU25-LYS292 | |
| C | GLU25-LYS292 | |
| D | GLU25-LYS292 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 4 |
| Details | ACT_SITE: Proton acceptor |
| Chain | Residue | Details |
| A | TYR183 | |
| B | TYR183 | |
| C | TYR183 | |
| D | TYR183 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 20 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15513927, ECO:0000269|PubMed:17919905, ECO:0000269|PubMed:18069989, ECO:0000269|PubMed:18485702, ECO:0000269|PubMed:18553955, ECO:0000269|PubMed:19217779 |
| Chain | Residue | Details |
| A | GLY41 | |
| B | ILE218 | |
| C | GLY41 | |
| C | THR92 | |
| C | ASN119 | |
| C | TYR183 | |
| C | ILE218 | |
| D | GLY41 | |
| D | THR92 | |
| D | ASN119 | |
| D | TYR183 | |
| A | THR92 | |
| D | ILE218 | |
| A | ASN119 | |
| A | TYR183 | |
| A | ILE218 | |
| B | GLY41 | |
| B | THR92 | |
| B | ASN119 | |
| B | TYR183 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 4 |
| Details | BINDING: BINDING => ECO:0000269|PubMed:15513927, ECO:0007744|PDB:1XU7, ECO:0007744|PDB:1XU9 |
| Chain | Residue | Details |
| A | SER170 | |
| B | SER170 | |
| C | SER170 | |
| D | SER170 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 8 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000269|PubMed:19159218 |
| Chain | Residue | Details |
| A | ASN123 | |
| A | ASN162 | |
| B | ASN123 | |
| B | ASN162 | |
| C | ASN123 | |
| C | ASN162 | |
| D | ASN123 | |
| D | ASN162 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 4 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255 |
| Chain | Residue | Details |
| A | ASN207 | |
| B | ASN207 | |
| C | ASN207 | |
| D | ASN207 |
