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2EZ4
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PYRUVATE OXIDASE VARIANT F479W
Descriptor:Pyruvate oxidase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.
Deposit date:2005-11-10
Release date:2006-04-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.03 Å)
Cite:The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.
Nat.Chem.Biol., 2, 2006
2EZ8
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PYRUVATE OXIDASE VARIANT F479W IN COMPLEX WITH REACTION INTERMEDIATE 2-LACTYL-THIAMIN DIPHOSPHATE
Descriptor:Pyruvate oxidase, MAGNESIUM ION, SODIUM ION, ...
Authors:Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.
Deposit date:2005-11-10
Release date:2006-04-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.963 Å)
Cite:The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.
Nat.Chem.Biol., 2, 2006
2EZ9
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PYRUVATE OXIDASE VARIANT F479W IN COMPLEX WITH REACTION INTERMEDIATE ANALOGUE 2-PHOSPHONOLACTYL-THIAMIN DIPHOSPHATE
Descriptor:Pyruvate oxidase, MAGNESIUM ION, SODIUM ION, ...
Authors:Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.
Deposit date:2005-11-10
Release date:2006-04-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.
Nat.Chem.Biol., 2, 2006
2EZT
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PYRUVATE OXIDASE VARIANT F479W IN COMPLEX WITH REACTION INTERMEDIATE 2-HYDROXYETHYL-THIAMIN DIPHOSPHATE
Descriptor:Pyruvate oxidase, MAGNESIUM ION, PHOSPHATE ION, ...
Authors:Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.
Deposit date:2005-11-10
Release date:2006-04-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.29 Å)
Cite:The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.
Nat.Chem.Biol., 2, 2006
2EZU
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PYRUVATE OXIDASE VARIANT F479W IN COMPLEX WITH REACTION INTERMEDIATE 2-ACETYL-THIAMIN DIPHOSPHATE
Descriptor:Pyruvate oxidase, MAGNESIUM ION, SODIUM ION, ...
Authors:Wille, G., Meyer, D., Steinmetz, A., Hinze, E., Golbik, R., Tittmann, K.
Deposit date:2005-11-10
Release date:2006-04-25
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.16 Å)
Cite:The catalytic cycle of a thiamin diphosphate enzyme examined by cryocrystallography.
Nat.Chem.Biol., 2, 2006
2HXX
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AMINOTRYPTOPHAN BARSTAR
Descriptor:Barstar
Authors:Rubini, M., Lepthien, S., Golbik, R., Budisa, N.
Deposit date:2006-08-04
Release date:2006-08-22
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2 Å)
Cite:Aminotryptophan-containing barstar
BIOCHIM.BIOPHYS.ACTA, 1764, 2006
3FZN
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INTERMEDIATE ANALOGUE IN BENZOYLFORMATE DECARBOXYLASE
Descriptor:Benzoylformate decarboxylase, 3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-2-{(S)-hydroxy[(R)-hydroxy(methoxy)phosphoryl]phenylmethyl}-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium, MAGNESIUM ION, ...
Authors:Bruning, M., Berheide, M., Meyer, D., Golbik, R., Bartunik, H., Liese, A., Tittmann, K.
Deposit date:2009-01-26
Release date:2009-05-05
Last modified:2017-11-01
Method:X-RAY DIFFRACTION (1.62 Å)
Cite:Structural and kinetic studies on native intermediates and an intermediate analogue in benzoylformate decarboxylase reveal a least motion mechanism with an unprecedented short-lived predecarboxylation intermediate.
Biochemistry, 48, 2009
1JON
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GROEL (HSP60 CLASS) FRAGMENT COMPRISING RESIDUES 191-345
Descriptor:GROEL, HSP60 CLASS
Authors:Buckle, A.M., Fersht, A.R.
Deposit date:1996-05-30
Release date:1997-03-12
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Chaperone activity and structure of monomeric polypeptide binding domains of GroEL.
Proc.Natl.Acad.Sci.USA, 93, 1996
2R5N
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CRYSTAL STRUCTURE OF TRANSKETOLASE FROM ESCHERICHIA COLI IN NONCOVALENT COMPLEX WITH ACCEPTOR ALDOSE RIBOSE 5-PHOSPHATE
Descriptor:Transketolase 1, RIBOSE-5-PHOSPHATE, CALCIUM ION, ...
Authors:Parthier, C., Asztalos, P., Wille, G., Tittmann, K.
Deposit date:2007-09-04
Release date:2007-11-06
Last modified:2018-01-24
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Strain and Near Attack Conformers in Enzymic Thiamin Catalysis: X-ray Crystallographic Snapshots of Bacterial Transketolase in Covalent Complex with Donor Ketoses Xylulose 5-phosphate and Fructose 6-phosphate, and in Noncovalent Complex with Acceptor Aldose Ribose 5-phosphate.
Biochemistry, 46, 2007
2R8O
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TRANSKETOLASE FROM E. COLI IN COMPLEX WITH SUBSTRATE D-XYLULOSE-5-PHOSPHATE
Descriptor:Transketolase 1, CALCIUM ION, 2-C-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium-2-yl}-5-O-phosphono-D-xylitol, ...
Authors:Wille, G., Asztalos, P., Weiss, M.S., Tittmann, K.
Deposit date:2007-09-11
Release date:2007-12-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.47 Å)
Cite:Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with acceptor aldose ribose 5-phosphate.
Biochemistry, 46, 2007
2R8P
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TRANSKETOLASE FROM E. COLI IN COMPLEX WITH SUBSTRATE D-FRUCTOSE-6-PHOSPHATE
Descriptor:Transketolase 1, CALCIUM ION, 2-C-{3-[(4-amino-2-methylpyrimidin-5-yl)methyl]-5-(2-{[(R)-hydroxy(phosphonooxy)phosphoryl]oxy}ethyl)-4-methyl-1,3-thiazol-3-ium-2-yl}-6-O-phosphono-D-glucitol, ...
Authors:Wille, G., Asztalos, P., Weiss, M.S., Tittmann, K.
Deposit date:2007-09-11
Release date:2007-12-11
Last modified:2017-10-25
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Strain and near attack conformers in enzymic thiamin catalysis: X-ray crystallographic snapshots of bacterial transketolase in covalent complex with donor ketoses xylulose 5-phosphate and fructose 6-phosphate, and in noncovalent complex with acceptor aldose ribose 5-phosphate.
Biochemistry, 46, 2007
3S0C
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TRANSALDOLASE WT OF THERMOPLASMA ACIDOPHILUM
Descriptor:Probable transaldolase, GLYCEROL
Authors:Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.
Deposit date:2011-05-13
Release date:2011-08-24
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.78 Å)
Cite:Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism.
Nat.Chem.Biol., 7, 2011
3S1U
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TRANSALDOLASE FROM THERMOPLASMA ACIDOPHILUM IN COMPLEX WITH D-ERYTHROSE 4-PHOSPHATE
Descriptor:Probable transaldolase, ERYTHOSE-4-PHOSPHATE, CHLORIDE ION
Authors:Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.
Deposit date:2011-05-16
Release date:2011-08-24
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism.
Nat.Chem.Biol., 7, 2011
3S1V
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TRANSALDOLASE FROM THERMOPLASMA ACIDOPHILUM IN COMPLEX WITH D-FRUCTOSE 6-PHOSPHATE SCHIFF-BASE INTERMEDIATE
Descriptor:Probable transaldolase, GLYCEROL, FRUCTOSE -6-PHOSPHATE
Authors:Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.
Deposit date:2011-05-16
Release date:2011-08-24
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism.
Nat.Chem.Biol., 7, 2011
3S1W
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TRANSALDOLASE VARIANT LYS86ALA FROM THERMOPLASMA ACIDOPHILUM IN COMPLEX WITH GLYCEROL AND CITRATE
Descriptor:Probable transaldolase, GLYCEROL, CITRATE ANION
Authors:Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.
Deposit date:2011-05-16
Release date:2011-08-24
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism.
Nat.Chem.Biol., 7, 2011
3S1X
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TRANSALDOLASE FROM THERMOPLASMA ACIDOPHILUM IN COMPLEX WITH D-SEDOHEPTULOSE 7-PHOSPHATE SCHIFF-BASE INTERMEDIATE
Descriptor:Probable transaldolase, D-ALTRO-HEPT-2-ULOSE 7-PHOSPHATE
Authors:Lehwess-Litzmann, A., Neumann, P., Parthier, C., Tittmann, K.
Deposit date:2011-05-16
Release date:2011-08-24
Last modified:2011-10-05
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Twisted Schiff base intermediates and substrate locale revise transaldolase mechanism.
Nat.Chem.Biol., 7, 2011
1GPU
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TRANSKETOLASE COMPLEX WITH REACTION INTERMEDIATE
Descriptor:TRANSKETOLASE 1, CALCIUM ION, 2-[3-[(4-AMINO-2-METHYL-5-PYRIMIDINYL)METHYL]-2-(1,2-DIHYDROXYETHYL)-4-METHYL-1,3-THIAZOL-3-IUM-5-YL]ETHYL TRIHYDROGEN DIPHOSPHATE
Authors:Fiedler, E., Thorell, S., Sandalova, T., Koenig, S., Schneider, G.
Deposit date:2001-11-09
Release date:2002-02-11
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (1.86 Å)
Cite:Snapshot of a Key Intermediate in Enzymatic Thiamin Catalysis: Crystal Structure of the Alpha-Carbanion of (Alpha,Beta-Dihydroxyethyl)-Thiamin Diphosphate in the Active Site of Transketolase from Saccharomyces Cerevisiae.
Proc.Natl.Acad.Sci.USA, 99, 2002
2OZL
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HUMAN PYRUVATE DEHYDROGENASE S264E VARIANT
Descriptor:Pyruvate dehydrogenase E1 component alpha subunit, somatic form, Pyruvate dehydrogenase E1 component subunit beta, ...
Authors:Ciszak, E.M., Dominiak, P.M., Patel, M.S., Korotchkina, L.G.
Deposit date:2007-02-26
Release date:2007-05-22
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (1.9 Å)
Cite:Phosphorylation of Serine 264 Impedes Active Site Accessibility in the E1 Component of the Human Pyruvate Dehydrogenase Multienzyme Complex
Biochemistry, 46, 2007
2Q27
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CRYSTAL STRUCTURE OF OXALYL-COA DECARBOXYLASE FROM ESCHERICHIA COLI
Descriptor:oxalyl-CoA decarboxylase, MAGNESIUM ION, SULFATE ION, ...
Authors:Werther, T., Zimmer, A., Wille, G., Hubner, G., Weiss, M.S., Konig, S.
Deposit date:2007-05-26
Release date:2008-06-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:New insights into structure-function relationships of oxalyl CoA decarboxylase from Escherichia coli.
Febs J., 277, 2010
2Q28
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CRYSTAL STRUCTURE OF OXALYL-COA DECARBOXYLASE FROM ESCHERICHIA COLI IN COMPLEX WITH ADENOSINE-5`-DIPHOSPHATE
Descriptor:oxalyl-CoA decarboxylase, MAGNESIUM ION, SULFATE ION, ...
Authors:Werther, T., Zimmer, A., Wille, G., Hubner, G., Weiss, M.S., Konig, S.
Deposit date:2007-05-26
Release date:2008-06-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.74 Å)
Cite:New insights into structure-function relationships of oxalyl CoA decarboxylase from Escherichia coli.
Febs J., 277, 2010
2Q29
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CRYSTAL STRUCTURE OF OXALYL-COA DECARBOXYLASE FROM ESCHERICHIA COLI IN COMPLEX WITH ACETYL COENZYME A
Descriptor:oxalyl-CoA decarboxylase, MAGNESIUM ION, ACETYL COENZYME *A, ...
Authors:Werther, T., Zimmer, A., Wille, G., Hubner, G., Weiss, M.S., Konig, S.
Deposit date:2007-05-26
Release date:2008-06-03
Last modified:2017-10-18
Method:X-RAY DIFFRACTION (1.82 Å)
Cite:New insights into structure-function relationships of oxalyl CoA decarboxylase from Escherichia coli.
Febs J., 277, 2010
2VJY
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PYRUVATE DECARBOXYLASE FROM KLUYVEROMYCES LACTIS IN COMPLEX WITH THE SUBSTRATE ANALOGUE METHYL ACETYLPHOSPHONATE
Descriptor:PYRUVATE DECARBOXYLASE, THIAMINE DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kutter, S., Wille, G., Weiss, M.S., Konig, S.
Deposit date:2007-12-14
Release date:2009-01-27
Last modified:2019-07-24
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Covalently Bound Substrate at the Regulatory Site of Yeast Pyruvate Decarboxylases Triggers Allosteric Enzyme Activation.
J.Biol.Chem., 284, 2009
2VK1
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CRYSTAL STRUCTURE OF THE SACCHAROMYCES CEREVISIAE PYRUVATE DECARBOXYLASE VARIANT D28A IN COMPLEX WITH ITS SUBSTRATE
Descriptor:PYRUVATE DECARBOXYLASE ISOZYME 1, THIAMINE DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kutter, S., Weik, M., Weiss, M.S., Konig, S.
Deposit date:2007-12-16
Release date:2009-01-27
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.71 Å)
Cite:Covalently Bound Substrate at the Regulatory Site of Yeast Pyruvate Decarboxylases Triggers Allosteric Enzyme Activation.
J.Biol.Chem., 284, 2009
2VK8
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CRYSTAL STRUCTURE OF THE SACCHAROMYCES CEREVISIAE PYRUVATE DECARBOXYLASE VARIANT E477Q IN COMPLEX WITH ITS SUBSTRATE
Descriptor:PYRUVATE DECARBOXYLASE ISOZYME 1, THIAMINE DIPHOSPHATE, MAGNESIUM ION, ...
Authors:Kutter, S., Weik, M., Weiss, M.S., Konig, S.
Deposit date:2007-12-17
Release date:2009-01-27
Last modified:2019-02-06
Method:X-RAY DIFFRACTION (1.42 Å)
Cite:Covalently Bound Substrate at the Regulatory Site of Yeast Pyruvate Decarboxylases Triggers Allosteric Enzyme Activation.
J.Biol.Chem., 284, 2009
6EFH
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PYRUVATE DECARBOXYLASE FROM KLUYVEROMYCES LACTIS SOAKED WITH PYRUVAMIDE
Descriptor:Pyruvate decarboxylase, (1S,2S)-1-amino-1,2-dihydroxypropan-1-olate, THIAMINE DIPHOSPHATE, ...
Authors:Kutter, S., Konig, S.
Deposit date:2018-08-16
Release date:2018-08-29
Method:X-RAY DIFFRACTION (2.99 Å)
Cite:The crystal structures of pyruvate decarboxylase from Kluyveromyces lactis in the absence of ligands and in the presence of the substrate surrogate pyruvamide
To be Published