2OZL

Human pyruvate dehydrogenase S264E variant

Summary for 2OZL

Entry DOI	10.2210/pdb2ozl/pdb
Descriptor	Pyruvate dehydrogenase E1 component alpha subunit, somatic form, Pyruvate dehydrogenase E1 component subunit beta, MAGNESIUM ION, ... (6 entities in total)
Functional Keywords	pyruvate_dehydrogenase_complex; human; e1; multienzyme_complex_component; thiamine_pyrophosphate; thiamin_diphosphate; heterotetrameric; lipoyl_substrate; pyruvate; dihydrolipoamide_acetyltransferase; dihydrolipoamide_dehydrogenase;, oxidoreductase
Biological source	Homo sapiens (human) More
Cellular location	Mitochondrion matrix: P08559 P11177
Total number of polymer chains	4
Total formula weight	157184.15
Authors	Ciszak, E.M.,Dominiak, P.M.,Patel, M.S.,Korotchkina, L.G. (deposition date: 2007-02-26, release date: 2007-05-22, Last modification date: 2023-08-30)
Primary citation	Seifert, F.,Ciszak, E.M.,Korotchkina, L.G.,Golbik, R.,Spinka, M.,Dominiak, P.M.,Sidhu, S.,Brauer, J.,Patel, M.S.,Tittmann, K. Phosphorylation of Serine 264 Impedes Active Site Accessibility in the E1 Component of the Human Pyruvate Dehydrogenase Multienzyme Complex Biochemistry, 46:6277-6287, 2007 Cited by PubMed: 17474719 DOI: 10.1021/bi700083z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation